Bioprinting of 3D in vitro skeletal muscle models: A review
Recent years have witnessed significant progress in skeletal muscle tissue regeneration. Numerous bioengineering approaches have been implemented to construct in vitro skeletal muscle tissues with high fidelity. Nevertheless, an in vitro model that is capable of restoring mature muscle, vasculature,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127520303282 |
| _version_ | 1818117681727930368 |
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| author | Pei Zhuang Jia An Chee Kai Chua Lay Poh Tan |
| author_facet | Pei Zhuang Jia An Chee Kai Chua Lay Poh Tan |
| author_sort | Pei Zhuang |
| collection | DOAJ |
| description | Recent years have witnessed significant progress in skeletal muscle tissue regeneration. Numerous bioengineering approaches have been implemented to construct in vitro skeletal muscle tissues with high fidelity. Nevertheless, an in vitro model that is capable of restoring mature muscle, vasculature, and ECM composition to the damaged tissue has yet to be achieved. Herein, we critically review the development and progress in tissue engineering skeletal muscle models. We outline the physiology of native skeletal muscle and the design criteria of engineering biomimetic skeletal muscle tissues are discussed. The influential parameters that modulating skeletal muscle cell behavior are highlighted. Subsequently, we critically review the 3D skeletal muscle models using various bioengineering strategies, including 3D geometrical confinement, electrospinning, porous hydrogels, the controlled cell/molecule delivery, and particularly, 3D bioprinting technology. We draw on specific examples to discuss the merits and limitations of each method. A short description of the challenges and future directions is provided. |
| first_indexed | 2024-12-11T04:42:17Z |
| format | Article |
| id | doaj.art-74c330dcabae419b96a1165439be3a43 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-11T04:42:17Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-74c330dcabae419b96a1165439be3a432022-12-22T01:20:36ZengElsevierMaterials & Design0264-12752020-08-01193108794Bioprinting of 3D in vitro skeletal muscle models: A reviewPei Zhuang0Jia An1Chee Kai Chua2Lay Poh Tan3Singapore Centre for 3D Printing, School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, SingaporeSingapore Centre for 3D Printing, School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, SingaporeEngineering Product Development Pillar, Singapore University of Technology and Design, 8 Somapah Rd, 487372 Singapore, SingaporeSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore; Corresponding author.Recent years have witnessed significant progress in skeletal muscle tissue regeneration. Numerous bioengineering approaches have been implemented to construct in vitro skeletal muscle tissues with high fidelity. Nevertheless, an in vitro model that is capable of restoring mature muscle, vasculature, and ECM composition to the damaged tissue has yet to be achieved. Herein, we critically review the development and progress in tissue engineering skeletal muscle models. We outline the physiology of native skeletal muscle and the design criteria of engineering biomimetic skeletal muscle tissues are discussed. The influential parameters that modulating skeletal muscle cell behavior are highlighted. Subsequently, we critically review the 3D skeletal muscle models using various bioengineering strategies, including 3D geometrical confinement, electrospinning, porous hydrogels, the controlled cell/molecule delivery, and particularly, 3D bioprinting technology. We draw on specific examples to discuss the merits and limitations of each method. A short description of the challenges and future directions is provided.http://www.sciencedirect.com/science/article/pii/S02641275203032823D bioprintingSkeletal muscleIn vitro modelBioengineering strategies |
| spellingShingle | Pei Zhuang Jia An Chee Kai Chua Lay Poh Tan Bioprinting of 3D in vitro skeletal muscle models: A review Materials & Design 3D bioprinting Skeletal muscle In vitro model Bioengineering strategies |
| title | Bioprinting of 3D in vitro skeletal muscle models: A review |
| title_full | Bioprinting of 3D in vitro skeletal muscle models: A review |
| title_fullStr | Bioprinting of 3D in vitro skeletal muscle models: A review |
| title_full_unstemmed | Bioprinting of 3D in vitro skeletal muscle models: A review |
| title_short | Bioprinting of 3D in vitro skeletal muscle models: A review |
| title_sort | bioprinting of 3d in vitro skeletal muscle models a review |
| topic | 3D bioprinting Skeletal muscle In vitro model Bioengineering strategies |
| url | http://www.sciencedirect.com/science/article/pii/S0264127520303282 |
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