Diagnostic Performance of Prototype Handheld Ultrasound According to the Fifth Edition of BI-RADS for Breast Ultrasound Compared with Automated Breast Ultrasound among Females with Positive Lumps

(1) Objective: To evaluate the diagnostic performance of prototype handheld ultrasound compared to automated breast ultrasound, according to the fifth edition of BI-RADS categorization, among females with positive lumps. (2) Methods: A total of 1004 lesions in 162 participants who underwent both pro...

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Main Authors: Shahad A. Ibraheem, Rozi Mahmud, Suraini Mohamad Saini, Hasyma Abu Hassan, Aysar Sabah Keiteb
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Diagnostics
Subjects:
Online Access:https://www.mdpi.com/2075-4418/13/6/1065
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author Shahad A. Ibraheem
Rozi Mahmud
Suraini Mohamad Saini
Hasyma Abu Hassan
Aysar Sabah Keiteb
author_facet Shahad A. Ibraheem
Rozi Mahmud
Suraini Mohamad Saini
Hasyma Abu Hassan
Aysar Sabah Keiteb
author_sort Shahad A. Ibraheem
collection DOAJ
description (1) Objective: To evaluate the diagnostic performance of prototype handheld ultrasound compared to automated breast ultrasound, according to the fifth edition of BI-RADS categorization, among females with positive lumps. (2) Methods: A total of 1004 lesions in 162 participants who underwent both prototype handheld ultrasound and automated breast ultrasound were included. Two radiologists and a sonographer independently evaluated the sonographic features of each lesion according to the fifth BI-RADS edition. The kappa coefficient (κ) was calculated for each BI-RADS descriptor and final assessment category. The cross-tabulation was performed to see whether there were differences between the ABUS and prototype HHUS results. Specificity and sensitivity were evaluated and compared using the McNamar test. (3) Results: ABUS and prototype HHUS observers found the same number of breast lesions in the 324 breasts of the 162 respondents. There was no significant difference in the mean lesion size, with a maximum mean length dimension of 0.48 ± 0.33 cm. The assessment of the lesion’s shape, orientation, margin, echo pattern, posterior acoustic features, and calcification was obtained with good to excellent agreements between ABUS and prototype HHUS observers (κ = 0.70–1.0). There was absolutely no significant difference between ABUS and prototype HHUS in assessment of lesion except for lesion orientation <i>p</i> = 0.00. Diagnostic accuracy (99.8% and 97.7–98.9%), sensitivity (99.5% and 98.0–99.0%), specificity (99.8% and 99.6–99.8%), positive predictive value (98.1% and 90.3–96.2%), negative predictive value (90.0% and 84.4–88.7%), and areas under the curve (0.98 and 0.83–0.92; <i>p</i> < 0.05) were not significantly different between ABUS and prototype HHUS observers. (4) Conclusion: According to the fifth BI-RADS edition, automated breast ultrasound is not statistically significantly different from prototype handheld ultrasound with regard to interobserver variability and diagnostic performance.
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spelling doaj.art-74c77424548c422bb38b5c543518c6232023-11-17T10:33:51ZengMDPI AGDiagnostics2075-44182023-03-01136106510.3390/diagnostics13061065Diagnostic Performance of Prototype Handheld Ultrasound According to the Fifth Edition of BI-RADS for Breast Ultrasound Compared with Automated Breast Ultrasound among Females with Positive LumpsShahad A. Ibraheem0Rozi Mahmud1Suraini Mohamad Saini2Hasyma Abu Hassan3Aysar Sabah Keiteb4Department of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, MalaysiaDepartment of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, MalaysiaDepartment of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, MalaysiaDepartment of Radiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, MalaysiaDepartment of Radiological Techniques, College of Health and Medical Technologies, Baghdad 10047, Iraq(1) Objective: To evaluate the diagnostic performance of prototype handheld ultrasound compared to automated breast ultrasound, according to the fifth edition of BI-RADS categorization, among females with positive lumps. (2) Methods: A total of 1004 lesions in 162 participants who underwent both prototype handheld ultrasound and automated breast ultrasound were included. Two radiologists and a sonographer independently evaluated the sonographic features of each lesion according to the fifth BI-RADS edition. The kappa coefficient (κ) was calculated for each BI-RADS descriptor and final assessment category. The cross-tabulation was performed to see whether there were differences between the ABUS and prototype HHUS results. Specificity and sensitivity were evaluated and compared using the McNamar test. (3) Results: ABUS and prototype HHUS observers found the same number of breast lesions in the 324 breasts of the 162 respondents. There was no significant difference in the mean lesion size, with a maximum mean length dimension of 0.48 ± 0.33 cm. The assessment of the lesion’s shape, orientation, margin, echo pattern, posterior acoustic features, and calcification was obtained with good to excellent agreements between ABUS and prototype HHUS observers (κ = 0.70–1.0). There was absolutely no significant difference between ABUS and prototype HHUS in assessment of lesion except for lesion orientation <i>p</i> = 0.00. Diagnostic accuracy (99.8% and 97.7–98.9%), sensitivity (99.5% and 98.0–99.0%), specificity (99.8% and 99.6–99.8%), positive predictive value (98.1% and 90.3–96.2%), negative predictive value (90.0% and 84.4–88.7%), and areas under the curve (0.98 and 0.83–0.92; <i>p</i> < 0.05) were not significantly different between ABUS and prototype HHUS observers. (4) Conclusion: According to the fifth BI-RADS edition, automated breast ultrasound is not statistically significantly different from prototype handheld ultrasound with regard to interobserver variability and diagnostic performance.https://www.mdpi.com/2075-4418/13/6/1065prototype handheld ultrasoundBI-RADSABUSbreast cancerHHUS
spellingShingle Shahad A. Ibraheem
Rozi Mahmud
Suraini Mohamad Saini
Hasyma Abu Hassan
Aysar Sabah Keiteb
Diagnostic Performance of Prototype Handheld Ultrasound According to the Fifth Edition of BI-RADS for Breast Ultrasound Compared with Automated Breast Ultrasound among Females with Positive Lumps
Diagnostics
prototype handheld ultrasound
BI-RADS
ABUS
breast cancer
HHUS
title Diagnostic Performance of Prototype Handheld Ultrasound According to the Fifth Edition of BI-RADS for Breast Ultrasound Compared with Automated Breast Ultrasound among Females with Positive Lumps
title_full Diagnostic Performance of Prototype Handheld Ultrasound According to the Fifth Edition of BI-RADS for Breast Ultrasound Compared with Automated Breast Ultrasound among Females with Positive Lumps
title_fullStr Diagnostic Performance of Prototype Handheld Ultrasound According to the Fifth Edition of BI-RADS for Breast Ultrasound Compared with Automated Breast Ultrasound among Females with Positive Lumps
title_full_unstemmed Diagnostic Performance of Prototype Handheld Ultrasound According to the Fifth Edition of BI-RADS for Breast Ultrasound Compared with Automated Breast Ultrasound among Females with Positive Lumps
title_short Diagnostic Performance of Prototype Handheld Ultrasound According to the Fifth Edition of BI-RADS for Breast Ultrasound Compared with Automated Breast Ultrasound among Females with Positive Lumps
title_sort diagnostic performance of prototype handheld ultrasound according to the fifth edition of bi rads for breast ultrasound compared with automated breast ultrasound among females with positive lumps
topic prototype handheld ultrasound
BI-RADS
ABUS
breast cancer
HHUS
url https://www.mdpi.com/2075-4418/13/6/1065
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