Association between the degree of obstructive sleep apnea and the severity of COVID-19: An explorative retrospective cross-sectional study.

Obstructive sleep apnea (OSA) on its own, as well as its risk factors, have been found to be associated with the outcome of Coronavirus disease 2019 (COVID-19). However, the association between the degree of OSA and COVID-19 severity is unclear. Therefore, the aim of the study was to evaluate whethe...

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Main Authors: J P T F Ho, H C M Donders, N Zhou, K Schipper, N Su, J de Lange
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0257483
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author J P T F Ho
H C M Donders
N Zhou
K Schipper
N Su
J de Lange
author_facet J P T F Ho
H C M Donders
N Zhou
K Schipper
N Su
J de Lange
author_sort J P T F Ho
collection DOAJ
description Obstructive sleep apnea (OSA) on its own, as well as its risk factors, have been found to be associated with the outcome of Coronavirus disease 2019 (COVID-19). However, the association between the degree of OSA and COVID-19 severity is unclear. Therefore, the aim of the study was to evaluate whether or not parameters to clinically evaluate OSA severity and the type of OSA treatment are associated with COVID-19 severity. Patient data from OSA patients diagnosed with COVID-19 were reviewed from outpatients from the Isala Hospital and patients admitted to the Isala Hospital, starting from March until December 2020. Baseline patient data, sleep study parameters, OSA treatment information and hospital admission data were collected. Apnea hypopnea index (AHI), low oxyhemoglobin desaturation (LSAT), oxygen desaturation index (ODI), respiratory disturbance index (RDI), and the type of OSA treatment were regarded as the independent variables. COVID-19 severity-based on hospital or intensive care unit (ICU) admission, the number of days of hospitalization, and number of intubation and mechanical ventilation days-were regarded as the outcome variables. Multinomial regression analysis, binary logistic regression analysis, and zero-inflated negative binomial regression analysis were used to assess the association between the parameters to clinically evaluate OSA severity and COVID-19 severity. A total of 137 patients were included. Only LSAT was found to be significantly associated with the COVID-19 severity (p<0.05) when COVID-19 severity was dichotomized as non-hospitalized or hospitalized and ICU admission or death. Therefore, our findings showed that LSAT seems to be a significant risk factor for COVID-19 severity. However, the degree of OSA-based on AHI, ODI, and RDI-and OSA treatment were not found to be risk factors for COVID-19 severity when looking at hospital or ICU admission, the number of days of hospitalization, and number of intubation and mechanical ventilation days.
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spelling doaj.art-74c7aab18db34bb6bfb175d9c396e7862022-12-21T19:23:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01169e025748310.1371/journal.pone.0257483Association between the degree of obstructive sleep apnea and the severity of COVID-19: An explorative retrospective cross-sectional study.J P T F HoH C M DondersN ZhouK SchipperN SuJ de LangeObstructive sleep apnea (OSA) on its own, as well as its risk factors, have been found to be associated with the outcome of Coronavirus disease 2019 (COVID-19). However, the association between the degree of OSA and COVID-19 severity is unclear. Therefore, the aim of the study was to evaluate whether or not parameters to clinically evaluate OSA severity and the type of OSA treatment are associated with COVID-19 severity. Patient data from OSA patients diagnosed with COVID-19 were reviewed from outpatients from the Isala Hospital and patients admitted to the Isala Hospital, starting from March until December 2020. Baseline patient data, sleep study parameters, OSA treatment information and hospital admission data were collected. Apnea hypopnea index (AHI), low oxyhemoglobin desaturation (LSAT), oxygen desaturation index (ODI), respiratory disturbance index (RDI), and the type of OSA treatment were regarded as the independent variables. COVID-19 severity-based on hospital or intensive care unit (ICU) admission, the number of days of hospitalization, and number of intubation and mechanical ventilation days-were regarded as the outcome variables. Multinomial regression analysis, binary logistic regression analysis, and zero-inflated negative binomial regression analysis were used to assess the association between the parameters to clinically evaluate OSA severity and COVID-19 severity. A total of 137 patients were included. Only LSAT was found to be significantly associated with the COVID-19 severity (p<0.05) when COVID-19 severity was dichotomized as non-hospitalized or hospitalized and ICU admission or death. Therefore, our findings showed that LSAT seems to be a significant risk factor for COVID-19 severity. However, the degree of OSA-based on AHI, ODI, and RDI-and OSA treatment were not found to be risk factors for COVID-19 severity when looking at hospital or ICU admission, the number of days of hospitalization, and number of intubation and mechanical ventilation days.https://doi.org/10.1371/journal.pone.0257483
spellingShingle J P T F Ho
H C M Donders
N Zhou
K Schipper
N Su
J de Lange
Association between the degree of obstructive sleep apnea and the severity of COVID-19: An explorative retrospective cross-sectional study.
PLoS ONE
title Association between the degree of obstructive sleep apnea and the severity of COVID-19: An explorative retrospective cross-sectional study.
title_full Association between the degree of obstructive sleep apnea and the severity of COVID-19: An explorative retrospective cross-sectional study.
title_fullStr Association between the degree of obstructive sleep apnea and the severity of COVID-19: An explorative retrospective cross-sectional study.
title_full_unstemmed Association between the degree of obstructive sleep apnea and the severity of COVID-19: An explorative retrospective cross-sectional study.
title_short Association between the degree of obstructive sleep apnea and the severity of COVID-19: An explorative retrospective cross-sectional study.
title_sort association between the degree of obstructive sleep apnea and the severity of covid 19 an explorative retrospective cross sectional study
url https://doi.org/10.1371/journal.pone.0257483
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