Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination

Bruton’s tyrosine kinase inhibition reduces disease severity in a model of secondary progressive autoimmune demyelination

Abstract Bruton’s tyrosine kinase (BTK) is an emerging target in multiple sclerosis (MS). Alongside its role in B cell receptor signaling and B cell development, BTK regulates myeloid cell activation and inflammatory responses. Here we demonstrate efficacy of BTK inhibition in a model of secondary p...

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Bibliographic Details
Main Authors: Kirsten Scarlett Evonuk, Sen Wang, Josh Mattie, C. J. Cracchiolo, Reine Mager, Željko Ferenčić, Ethan Sprague, Brandon Carrier, Kai Schofield, Evelyn Martinez, Zachary Stewart, Tara Petrosino, Gregory Andrew Johnson, Isharat Yusuf, Warren Plaisted, Zachary Naiman, Timothy Delp, Laura Carter, Suzana Marušić
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple sclerosis
Secondary progressive
Demyelination
Microglia
B cells
Myeloid cells
Online Access:https://doi.org/10.1186/s40478-023-01614-w

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