Synthesis, Characterization and Pharmacological Evaluation of 1-(2-Chloro-6-Fluorophenyl)-5-Methylindolin-2-One: A New Anti-Inflammatory Compound with Reduced Gastric Ulceration Properties

Synthesis, Characterization and Pharmacological Evaluation of 1-(2-Chloro-6-Fluorophenyl)-5-Methylindolin-2-One: A New Anti-Inflammatory Compound with Reduced Gastric Ulceration Properties

The new compound 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one (1), designed using the prodrug approach, was easily obtained in 85% yield and characterized by nuclear magnetic resonance, elemental analysis, mass spectrometry and infrared spectroscopy. The lactam 1 showed anti-inflammatory and an...

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Bibliographic Details
Main Authors:	Michel Leandro Campos, Jean Leandro dos Santos, Rafael Chelucci, Man Chin Chung, Richard Chiquetto, Rosangela Gonçalves Peccinini
Format:	Article
Language:	English
Published:	MDPI AG 2010-11-01
Series:	Molecules
Subjects:	pro-drug lactam lumiracoxib anti-inflammatory
Online Access:	http://www.mdpi.com/1420-3049/15/11/8039/

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