Comparative Study of the Effects of GLP1 Analog and SGLT2 Inhibitor against Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

Comparative Study of the Effects of GLP1 Analog and SGLT2 Inhibitor against Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

The present study investigated the possible cardioprotective effects of GLP1 and SGLT2i against diabetic cardiomyopathy (DCM) in type 2 diabetic rats and the possible underlying mechanisms. Methods: Thirty-two male Sprague Dawley rats were randomly subdivided into 4 equal groups: (a) control group,...

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Bibliographic Details
Main Authors: Abdelaziz M. Hussein, Elsayed A. Eid, Medhat Taha, Rami M. Elshazli, Raouf Fekry Bedir, Lashin Saad Lashin
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomedicines
Subjects:
type 2 dm
cardiomyopathy
oxidative stress
caspase-3
tgf-β
tnf-α and tyrosine hydroxylase
sglt2i
glp1
norepinephrine
Online Access:https://www.mdpi.com/2227-9059/8/3/43

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