The penumbra of randomized control trials
Pre-occupation with randomized control trials as the basis of evidence-based medicine has increasingly shadowed other study designs over the last half a century. These include surveys, case-control studies, and case-cohort studies. They have the potential to overcome several ethical and cost constra...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Perspectives in Clinical Research |
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| Online Access: | http://www.picronline.org/article.asp?issn=2229-3485;year=2013;volume=4;issue=3;spage=157;epage=159;aulast=Nanivadekar |
| _version_ | 1811310296752455680 |
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| author | Arun S Nanivadekar |
| author_facet | Arun S Nanivadekar |
| author_sort | Arun S Nanivadekar |
| collection | DOAJ |
| description | Pre-occupation with randomized control trials as the basis of evidence-based medicine has increasingly shadowed other study designs over the last half a century. These include surveys, case-control studies, and case-cohort studies. They have the potential to overcome several ethical and cost constraints, but depend on the embedding of research in routine practice, emphasis on relevant but limited, accurate, and complete data, harnessing of information technology for this purpose, and epidemiological and statistical literacy among clinicians. Only then will it be possible to nurture and network research-oriented practices by therapeutic areas. Given these, the alternative study designs can pave the way to regulatory reforms that will ultimately benefit the discoverers, approvers and users of health-care tools. |
| first_indexed | 2024-04-13T09:56:41Z |
| format | Article |
| id | doaj.art-74cb38d8242a4e92867967a043fb9aef |
| institution | Directory Open Access Journal |
| issn | 2229-3485 |
| language | English |
| last_indexed | 2024-04-13T09:56:41Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Perspectives in Clinical Research |
| spelling | doaj.art-74cb38d8242a4e92867967a043fb9aef2022-12-22T02:51:21ZengWolters Kluwer Medknow PublicationsPerspectives in Clinical Research2229-34852013-01-014315715910.4103/2229-3485.115371The penumbra of randomized control trialsArun S NanivadekarPre-occupation with randomized control trials as the basis of evidence-based medicine has increasingly shadowed other study designs over the last half a century. These include surveys, case-control studies, and case-cohort studies. They have the potential to overcome several ethical and cost constraints, but depend on the embedding of research in routine practice, emphasis on relevant but limited, accurate, and complete data, harnessing of information technology for this purpose, and epidemiological and statistical literacy among clinicians. Only then will it be possible to nurture and network research-oriented practices by therapeutic areas. Given these, the alternative study designs can pave the way to regulatory reforms that will ultimately benefit the discoverers, approvers and users of health-care tools.http://www.picronline.org/article.asp?issn=2229-3485;year=2013;volume=4;issue=3;spage=157;epage=159;aulast=NanivadekarNon-randomized control trial designspractice-embedded researchregulatory reforms |
| spellingShingle | Arun S Nanivadekar The penumbra of randomized control trials Perspectives in Clinical Research Non-randomized control trial designs practice-embedded research regulatory reforms |
| title | The penumbra of randomized control trials |
| title_full | The penumbra of randomized control trials |
| title_fullStr | The penumbra of randomized control trials |
| title_full_unstemmed | The penumbra of randomized control trials |
| title_short | The penumbra of randomized control trials |
| title_sort | penumbra of randomized control trials |
| topic | Non-randomized control trial designs practice-embedded research regulatory reforms |
| url | http://www.picronline.org/article.asp?issn=2229-3485;year=2013;volume=4;issue=3;spage=157;epage=159;aulast=Nanivadekar |
| work_keys_str_mv | AT arunsnanivadekar thepenumbraofrandomizedcontroltrials AT arunsnanivadekar penumbraofrandomizedcontroltrials |