Extra-adrenal pheochromocytoma with initial symptom of haemoptysis: a case report and review of literature
Abstract Background Pheochromocytoma is a catecholamine-secreting tumour that leads to various symptoms. Haemoptysis is rarely caused by a pheochromocytoma occurring outside the bronchus or thoracic cavity. Here, we report the case of an extra-adrenal abdominal pheochromocytoma initially manifesting...
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-020-01038-6 |
| _version_ | 1819296882600443904 |
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| author | Yutaka Endo Minoru Kitago Masahiro Shinoda Hiroshi Yagi Yuta Abe Shutaro Hori Masanori Odaira Takahiro Yokose Kaori Kameyama Yuko Kitagawa |
| author_facet | Yutaka Endo Minoru Kitago Masahiro Shinoda Hiroshi Yagi Yuta Abe Shutaro Hori Masanori Odaira Takahiro Yokose Kaori Kameyama Yuko Kitagawa |
| author_sort | Yutaka Endo |
| collection | DOAJ |
| description | Abstract Background Pheochromocytoma is a catecholamine-secreting tumour that leads to various symptoms. Haemoptysis is rarely caused by a pheochromocytoma occurring outside the bronchus or thoracic cavity. Here, we report the case of an extra-adrenal abdominal pheochromocytoma initially manifesting as haemoptysis/dyspnoea during exercise without classic symptoms. Case presentation A 22-year-old man with a history of severe dyspnoea experienced difficulties in breathing following a marathon owing to haemoptysis that required ventilator management 1 year before presentation. His father had undergone surgery for ectopic pheochromocytoma. Computed tomography (CT) revealed a 30-mm tumour between the inferior vena cava and pancreatic head while urinalysis revealed abnormally high noradrenaline levels. He was clinically diagnosed with an extra-adrenal abdominal ectopic pheochromocytoma. After controlling blood pressure, surgery was performed, and the tumour was successfully removed. Histopathology revealed chromogranin A (+), synaptophysin (+), S100 protein (+), and MIB-1 index of 1%. Therefore, the patient was finally diagnosed with extra-adrenal abdominal ectopic pheochromocytoma. Conclusions Haemoptysis is a rare manifestation of abdominal ectopic paraganglioma. Prompt consideration of pheochromocytoma/paraganglioma when patients experience haemoptysis without any other possible aetiology may prevent inappropriate diagnosis and treatment and ultimately fatalities. |
| first_indexed | 2024-12-24T05:05:10Z |
| format | Article |
| id | doaj.art-74cfc6806d5e4458b1c8ea841fa1d502 |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-12-24T05:05:10Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-74cfc6806d5e4458b1c8ea841fa1d5022022-12-21T17:13:51ZengBMCBMC Surgery1471-24822021-01-012111510.1186/s12893-020-01038-6Extra-adrenal pheochromocytoma with initial symptom of haemoptysis: a case report and review of literatureYutaka Endo0Minoru Kitago1Masahiro Shinoda2Hiroshi Yagi3Yuta Abe4Shutaro Hori5Masanori Odaira6Takahiro Yokose7Kaori Kameyama8Yuko Kitagawa9Department of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineDepartment of Surgery, Tokyo Saiseikai Central HospitalDepartment of Surgery, Keio University School of MedicineDepartment of Pathology, Keio University School of MedicineDepartment of Surgery, Keio University School of MedicineAbstract Background Pheochromocytoma is a catecholamine-secreting tumour that leads to various symptoms. Haemoptysis is rarely caused by a pheochromocytoma occurring outside the bronchus or thoracic cavity. Here, we report the case of an extra-adrenal abdominal pheochromocytoma initially manifesting as haemoptysis/dyspnoea during exercise without classic symptoms. Case presentation A 22-year-old man with a history of severe dyspnoea experienced difficulties in breathing following a marathon owing to haemoptysis that required ventilator management 1 year before presentation. His father had undergone surgery for ectopic pheochromocytoma. Computed tomography (CT) revealed a 30-mm tumour between the inferior vena cava and pancreatic head while urinalysis revealed abnormally high noradrenaline levels. He was clinically diagnosed with an extra-adrenal abdominal ectopic pheochromocytoma. After controlling blood pressure, surgery was performed, and the tumour was successfully removed. Histopathology revealed chromogranin A (+), synaptophysin (+), S100 protein (+), and MIB-1 index of 1%. Therefore, the patient was finally diagnosed with extra-adrenal abdominal ectopic pheochromocytoma. Conclusions Haemoptysis is a rare manifestation of abdominal ectopic paraganglioma. Prompt consideration of pheochromocytoma/paraganglioma when patients experience haemoptysis without any other possible aetiology may prevent inappropriate diagnosis and treatment and ultimately fatalities.https://doi.org/10.1186/s12893-020-01038-6Extra-adrenal abdominal pheochromocytomaHaemoptysisParaganglioma |
| spellingShingle | Yutaka Endo Minoru Kitago Masahiro Shinoda Hiroshi Yagi Yuta Abe Shutaro Hori Masanori Odaira Takahiro Yokose Kaori Kameyama Yuko Kitagawa Extra-adrenal pheochromocytoma with initial symptom of haemoptysis: a case report and review of literature BMC Surgery Extra-adrenal abdominal pheochromocytoma Haemoptysis Paraganglioma |
| title | Extra-adrenal pheochromocytoma with initial symptom of haemoptysis: a case report and review of literature |
| title_full | Extra-adrenal pheochromocytoma with initial symptom of haemoptysis: a case report and review of literature |
| title_fullStr | Extra-adrenal pheochromocytoma with initial symptom of haemoptysis: a case report and review of literature |
| title_full_unstemmed | Extra-adrenal pheochromocytoma with initial symptom of haemoptysis: a case report and review of literature |
| title_short | Extra-adrenal pheochromocytoma with initial symptom of haemoptysis: a case report and review of literature |
| title_sort | extra adrenal pheochromocytoma with initial symptom of haemoptysis a case report and review of literature |
| topic | Extra-adrenal abdominal pheochromocytoma Haemoptysis Paraganglioma |
| url | https://doi.org/10.1186/s12893-020-01038-6 |
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