The Sympathetic Nervous System in Dental Implantology
The sympathetic nervous system plays a vital role in various regulatory mechanisms. These include the well-known fight-or-flight response but also, for example, the processing of external stressors. In addition to many other tissues, the sympathetic nervous system influences bone metabolism. This ef...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/8/2907 |
| _version_ | 1797604877865582592 |
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| author | Johannes Raphael Kupka Keyvan Sagheb Bilal Al-Nawas Eik Schiegnitz |
| author_facet | Johannes Raphael Kupka Keyvan Sagheb Bilal Al-Nawas Eik Schiegnitz |
| author_sort | Johannes Raphael Kupka |
| collection | DOAJ |
| description | The sympathetic nervous system plays a vital role in various regulatory mechanisms. These include the well-known fight-or-flight response but also, for example, the processing of external stressors. In addition to many other tissues, the sympathetic nervous system influences bone metabolism. This effect could be highly relevant concerning osseointegration, which is responsible for the long-term success of dental implants. Accordingly, this review aims to summarize the current literature on this topic and to reveal future research perspectives. One in vitro study showed differences in mRNA expression of adrenoceptors cultured on implant surfaces. In vivo, sympathectomy impaired osseointegration in mice, while electrical stimulation of the sympathetic nerves promoted it. As expected, the beta-blocker propranolol improves histological implant parameters and micro-CT measurements. Overall, the present data are considered heterogeneous. However, the available publications reveal the potential for future research and development in dental implantology, which helps to introduce new therapeutic strategies and identify risk factors for dental implant failure. |
| first_indexed | 2024-03-11T04:54:04Z |
| format | Article |
| id | doaj.art-74d0513171d94b58af78ed028dcfe23d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T04:54:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-74d0513171d94b58af78ed028dcfe23d2023-11-17T19:50:08ZengMDPI AGJournal of Clinical Medicine2077-03832023-04-01128290710.3390/jcm12082907The Sympathetic Nervous System in Dental ImplantologyJohannes Raphael Kupka0Keyvan Sagheb1Bilal Al-Nawas2Eik Schiegnitz3Department of Oral and Maxillofacial Surgery, University Medical Center Mainz, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, 55131 Mainz, GermanyDepartment of Oral and Maxillofacial Surgery, University Medical Center Mainz, 55131 Mainz, GermanyThe sympathetic nervous system plays a vital role in various regulatory mechanisms. These include the well-known fight-or-flight response but also, for example, the processing of external stressors. In addition to many other tissues, the sympathetic nervous system influences bone metabolism. This effect could be highly relevant concerning osseointegration, which is responsible for the long-term success of dental implants. Accordingly, this review aims to summarize the current literature on this topic and to reveal future research perspectives. One in vitro study showed differences in mRNA expression of adrenoceptors cultured on implant surfaces. In vivo, sympathectomy impaired osseointegration in mice, while electrical stimulation of the sympathetic nerves promoted it. As expected, the beta-blocker propranolol improves histological implant parameters and micro-CT measurements. Overall, the present data are considered heterogeneous. However, the available publications reveal the potential for future research and development in dental implantology, which helps to introduce new therapeutic strategies and identify risk factors for dental implant failure.https://www.mdpi.com/2077-0383/12/8/2907sympathetic nervous systemadrenoceptordental implantologyoral surgery |
| spellingShingle | Johannes Raphael Kupka Keyvan Sagheb Bilal Al-Nawas Eik Schiegnitz The Sympathetic Nervous System in Dental Implantology Journal of Clinical Medicine sympathetic nervous system adrenoceptor dental implantology oral surgery |
| title | The Sympathetic Nervous System in Dental Implantology |
| title_full | The Sympathetic Nervous System in Dental Implantology |
| title_fullStr | The Sympathetic Nervous System in Dental Implantology |
| title_full_unstemmed | The Sympathetic Nervous System in Dental Implantology |
| title_short | The Sympathetic Nervous System in Dental Implantology |
| title_sort | sympathetic nervous system in dental implantology |
| topic | sympathetic nervous system adrenoceptor dental implantology oral surgery |
| url | https://www.mdpi.com/2077-0383/12/8/2907 |
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