Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties
Dental implants are widely used tooth replacement tools owing to their good oral rehabilitation and reconstruction capacities. Since dental implants are designed as a replacement for natural teeth, multi-functional abilities are desired to achieve successful implant treatment with improved osseointe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/10/14/4888 |
| _version_ | 1827712980085637120 |
|---|---|
| author | Sunho Park Hyeran Kim Kyoung Soon Choi Min-Kyung Ji Sujin Kim Yonghyun Gwon Chan Park Jangho Kim Hyun-Pil Lim |
| author_facet | Sunho Park Hyeran Kim Kyoung Soon Choi Min-Kyung Ji Sujin Kim Yonghyun Gwon Chan Park Jangho Kim Hyun-Pil Lim |
| author_sort | Sunho Park |
| collection | DOAJ |
| description | Dental implants are widely used tooth replacement tools owing to their good oral rehabilitation and reconstruction capacities. Since dental implants are designed as a replacement for natural teeth, multi-functional abilities are desired to achieve successful implant treatment with improved osseointegration through promotion of mammalian cell activity and prevention of bacterial cell activity. In this study, we developed a graphene–chitosan hybrid dental implant (GC hybrid implant) using various concentrations of graphene, which demonstrated the different surface properties including increased wettability and roughness. Importantly, the GC hybrid implant under the optimal condition (i.e., 1% GC hybrid implant) could significantly promote osteoblast proliferation while reducing biofilm formation and bacterial activity. Our study demonstrates the potential of using this GC hybrid implant as a new type of dental implant, which can offer an effective design for the fabrication of advanced dental implants. |
| first_indexed | 2024-03-10T18:25:49Z |
| format | Article |
| id | doaj.art-74d0d92cc65a4f80af365cb23adef58a |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T18:25:49Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-74d0d92cc65a4f80af365cb23adef58a2023-11-20T07:00:33ZengMDPI AGApplied Sciences2076-34172020-07-011014488810.3390/app10144888Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation PropertiesSunho Park0Hyeran Kim1Kyoung Soon Choi2Min-Kyung Ji3Sujin Kim4Yonghyun Gwon5Chan Park6Jangho Kim7Hyun-Pil Lim8Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju 61186, KoreaDepartment of Prosthodontics, School of Dentistry, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju 61186, KoreaNational Research Facilities & Equipment Center (NFEC), Korea Basic Science Institute (KBSI), 169-148 Gwahak-ro, Yuseong-gu, Daejeon 34133, KoreaOptoelectronics Convergence Research Center, Chonnam National University, Gwangju 61186, KoreaDepartment of Rural and Biosystems Engineering, Chonnam National University, Gwangju 61186, KoreaDepartment of Rural and Biosystems Engineering, Chonnam National University, Gwangju 61186, KoreaDepartment of Prosthodontics, School of Dentistry, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju 61186, KoreaDepartment of Rural and Biosystems Engineering, Chonnam National University, Gwangju 61186, KoreaDepartment of Prosthodontics, School of Dentistry, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju 61186, KoreaDental implants are widely used tooth replacement tools owing to their good oral rehabilitation and reconstruction capacities. Since dental implants are designed as a replacement for natural teeth, multi-functional abilities are desired to achieve successful implant treatment with improved osseointegration through promotion of mammalian cell activity and prevention of bacterial cell activity. In this study, we developed a graphene–chitosan hybrid dental implant (GC hybrid implant) using various concentrations of graphene, which demonstrated the different surface properties including increased wettability and roughness. Importantly, the GC hybrid implant under the optimal condition (i.e., 1% GC hybrid implant) could significantly promote osteoblast proliferation while reducing biofilm formation and bacterial activity. Our study demonstrates the potential of using this GC hybrid implant as a new type of dental implant, which can offer an effective design for the fabrication of advanced dental implants.https://www.mdpi.com/2076-3417/10/14/4888dental implantgraphene oxidechitosantitanium |
| spellingShingle | Sunho Park Hyeran Kim Kyoung Soon Choi Min-Kyung Ji Sujin Kim Yonghyun Gwon Chan Park Jangho Kim Hyun-Pil Lim Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties Applied Sciences dental implant graphene oxide chitosan titanium |
| title | Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties |
| title_full | Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties |
| title_fullStr | Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties |
| title_full_unstemmed | Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties |
| title_short | Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties |
| title_sort | graphene chitosan hybrid dental implants with enhanced antibacterial and cell proliferation properties |
| topic | dental implant graphene oxide chitosan titanium |
| url | https://www.mdpi.com/2076-3417/10/14/4888 |
| work_keys_str_mv | AT sunhopark graphenechitosanhybriddentalimplantswithenhancedantibacterialandcellproliferationproperties AT hyerankim graphenechitosanhybriddentalimplantswithenhancedantibacterialandcellproliferationproperties AT kyoungsoonchoi graphenechitosanhybriddentalimplantswithenhancedantibacterialandcellproliferationproperties AT minkyungji graphenechitosanhybriddentalimplantswithenhancedantibacterialandcellproliferationproperties AT sujinkim graphenechitosanhybriddentalimplantswithenhancedantibacterialandcellproliferationproperties AT yonghyungwon graphenechitosanhybriddentalimplantswithenhancedantibacterialandcellproliferationproperties AT chanpark graphenechitosanhybriddentalimplantswithenhancedantibacterialandcellproliferationproperties AT janghokim graphenechitosanhybriddentalimplantswithenhancedantibacterialandcellproliferationproperties AT hyunpillim graphenechitosanhybriddentalimplantswithenhancedantibacterialandcellproliferationproperties |