Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer
Emerging evidence shows a striking link between periodontal diseases and various human cancers including oral cancer. And periodontal pathogens, leading to periodontal diseases development, may serve a crucial role in oral cancer. This review elucidated the molecular mechanisms of periodontal pathog...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.919633/full |
| _version_ | 1818242886156681216 |
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| author | Tian-Jiao Li Yi-hang Hao Ya-ling Tang Xin-hua Liang |
| author_facet | Tian-Jiao Li Yi-hang Hao Ya-ling Tang Xin-hua Liang |
| author_sort | Tian-Jiao Li |
| collection | DOAJ |
| description | Emerging evidence shows a striking link between periodontal diseases and various human cancers including oral cancer. And periodontal pathogens, leading to periodontal diseases development, may serve a crucial role in oral cancer. This review elucidated the molecular mechanisms of periodontal pathogens in oral cancer. The pathogens directly engage in their own unique molecular dialogue with the host epithelium to acquire cancer phenotypes, and indirectly induce a proinflammatory environment and carcinogenic substance in favor of cancer development. And functional, rather than compositional, properties of oral microbial community correlated with cancer development are discussed. The effect of periodontal pathogens on periodontal diseases and oral cancer will further detail the pathogenesis of oral cancer and intensify the need of maintaining oral hygiene for the prevention of oral diseases including oral cancer. |
| first_indexed | 2024-12-12T13:52:21Z |
| format | Article |
| id | doaj.art-74d1963ba4784044878519c08900919a |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T13:52:21Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-74d1963ba4784044878519c08900919a2022-12-22T00:22:32ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-06-011310.3389/fmicb.2022.919633919633Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral CancerTian-Jiao Li0Yi-hang Hao1Ya-ling Tang2Xin-hua Liang3State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaEmerging evidence shows a striking link between periodontal diseases and various human cancers including oral cancer. And periodontal pathogens, leading to periodontal diseases development, may serve a crucial role in oral cancer. This review elucidated the molecular mechanisms of periodontal pathogens in oral cancer. The pathogens directly engage in their own unique molecular dialogue with the host epithelium to acquire cancer phenotypes, and indirectly induce a proinflammatory environment and carcinogenic substance in favor of cancer development. And functional, rather than compositional, properties of oral microbial community correlated with cancer development are discussed. The effect of periodontal pathogens on periodontal diseases and oral cancer will further detail the pathogenesis of oral cancer and intensify the need of maintaining oral hygiene for the prevention of oral diseases including oral cancer.https://www.frontiersin.org/articles/10.3389/fmicb.2022.919633/fullperiodontitisoral cancerOSCCperiodontal pathogensbacterialperiodontal disease |
| spellingShingle | Tian-Jiao Li Yi-hang Hao Ya-ling Tang Xin-hua Liang Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer Frontiers in Microbiology periodontitis oral cancer OSCC periodontal pathogens bacterial periodontal disease |
| title | Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
| title_full | Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
| title_fullStr | Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
| title_full_unstemmed | Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
| title_short | Periodontal Pathogens: A Crucial Link Between Periodontal Diseases and Oral Cancer |
| title_sort | periodontal pathogens a crucial link between periodontal diseases and oral cancer |
| topic | periodontitis oral cancer OSCC periodontal pathogens bacterial periodontal disease |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.919633/full |
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