SH3GLB1-related autophagy mediates mitochondrial metabolism to acquire resistance against temozolomide in glioblastoma

SH3GLB1-related autophagy mediates mitochondrial metabolism to acquire resistance against temozolomide in glioblastoma

Abstract Background The mechanism by which glioblastoma evades temozolomide (TMZ)-induced cytotoxicity is largely unknown. We hypothesized that mitochondria plays a role in this process. Methods RNA transcriptomes were obtained from tumor samples and online databases. Expression of different protein...

Full description

Bibliographic Details
Main Authors: Chia-Hung Chien, Wen-Bin Yang, Jian-Ying Chuang, Jung-Shun Lee, Wei-An Liao, Chih-Yuan Huang, Pin-Yuan Chen, An-Chih Wu, Shun-Tai Yang, Chien-Cheng Lai, Pei-I Chi, Jui-Mei Chu, Siao Muk Cheng, Chan-Chuan Liu, Daw-Yang Hwang, Shang-Hung Chen, Kwang-Yu Chang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
SH3GLB1
Temozolomide
Resistance
Mitochondrial functions
Autophagy
Online Access:https://doi.org/10.1186/s13046-022-02429-8

Internet

https://doi.org/10.1186/s13046-022-02429-8

Similar Items