Possible Male Reproduction Complications after Coronavirus Pandemic
Coronavirus disease 2019 (COVID-19), as a severe respiratory disease, affects various tissues and organs. The specific SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), is highly expressed in male gonads. Thus, male reproductive tissues could be a potential target for virus colonization....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2021-09-01
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| Series: | Cell Journal |
| Subjects: | |
| Online Access: | https://celljournal.org/journal/article/fulltext/possible-male-reproduction-complications-after-coronavirus-disease-20199.pdf |
| _version_ | 1818647329260961792 |
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| author | Maryam Hezavehei Bahare Shokoohian Mohammad Hossein Nasr-Esfahani Anastasia Shpichka Peter Timashev Abdolhossein Shahverdi Massoud Vosough |
| author_facet | Maryam Hezavehei Bahare Shokoohian Mohammad Hossein Nasr-Esfahani Anastasia Shpichka Peter Timashev Abdolhossein Shahverdi Massoud Vosough |
| author_sort | Maryam Hezavehei |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19), as a severe respiratory disease, affects various tissues and organs. The specific SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), is highly expressed in male gonads. Thus, male reproductive tissues could be a potential target for virus colonization. We performed a comprehensive search in PubMed and Google Scholar to retrieve relevant articles published till 15 April 2021. The keywords used were: male
fertility, male reproductive health, semen parameters, sex hormones, SARS-CoV-2, and COVID-19. Validated evidence about the adverse effects of the SARS-CoV-2 infection on the male reproductive system is limited and few studies have reported semen analysis results or presence of viral RNA in semen samples of infected men. Nevertheless, alterations
in reproductive hormones such as decreased level of testosterone (T) with raised luteinizing hormone (LH) have been reported in some patients. Although the impact of SARS-CoV-2 infection on the male reproduction health remains unclear, evidence suggests that male gonads may be potentially vulnerable to SARS-CoV-2 infection. In this article, we discussed the possible impacts of COVID-19 on male gonads, sex hormones, and semen quality and suggested preventive solutions. |
| first_indexed | 2024-12-17T01:00:48Z |
| format | Article |
| id | doaj.art-74d5f45e28024ce4b888aad91f66aa44 |
| institution | Directory Open Access Journal |
| issn | 2228-5806 2228-5814 |
| language | English |
| last_indexed | 2024-12-17T01:00:48Z |
| publishDate | 2021-09-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | Cell Journal |
| spelling | doaj.art-74d5f45e28024ce4b888aad91f66aa442022-12-21T22:09:27ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142021-09-0123438238810.22074/cellj.2021.7982Possible Male Reproduction Complications after Coronavirus PandemicMaryam Hezavehei0Bahare Shokoohian1Mohammad Hossein Nasr-Esfahani2Anastasia Shpichka3Peter Timashev4Abdolhossein Shahverdi5Massoud Vosough6Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranDepartment of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, IranInstitute for Regenerative Medicine, Sechenov University, Moscow, RussiaInstitute for Regenerative Medicine, Sechenov University, Moscow, RussiaDepartment of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, IranDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, IranCoronavirus disease 2019 (COVID-19), as a severe respiratory disease, affects various tissues and organs. The specific SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), is highly expressed in male gonads. Thus, male reproductive tissues could be a potential target for virus colonization. We performed a comprehensive search in PubMed and Google Scholar to retrieve relevant articles published till 15 April 2021. The keywords used were: male fertility, male reproductive health, semen parameters, sex hormones, SARS-CoV-2, and COVID-19. Validated evidence about the adverse effects of the SARS-CoV-2 infection on the male reproductive system is limited and few studies have reported semen analysis results or presence of viral RNA in semen samples of infected men. Nevertheless, alterations in reproductive hormones such as decreased level of testosterone (T) with raised luteinizing hormone (LH) have been reported in some patients. Although the impact of SARS-CoV-2 infection on the male reproduction health remains unclear, evidence suggests that male gonads may be potentially vulnerable to SARS-CoV-2 infection. In this article, we discussed the possible impacts of COVID-19 on male gonads, sex hormones, and semen quality and suggested preventive solutions.https://celljournal.org/journal/article/fulltext/possible-male-reproduction-complications-after-coronavirus-disease-20199.pdfcovid-19fertilitymale reproductionsars-cov-2semen |
| spellingShingle | Maryam Hezavehei Bahare Shokoohian Mohammad Hossein Nasr-Esfahani Anastasia Shpichka Peter Timashev Abdolhossein Shahverdi Massoud Vosough Possible Male Reproduction Complications after Coronavirus Pandemic Cell Journal covid-19 fertility male reproduction sars-cov-2 semen |
| title | Possible Male Reproduction Complications after Coronavirus Pandemic |
| title_full | Possible Male Reproduction Complications after Coronavirus Pandemic |
| title_fullStr | Possible Male Reproduction Complications after Coronavirus Pandemic |
| title_full_unstemmed | Possible Male Reproduction Complications after Coronavirus Pandemic |
| title_short | Possible Male Reproduction Complications after Coronavirus Pandemic |
| title_sort | possible male reproduction complications after coronavirus pandemic |
| topic | covid-19 fertility male reproduction sars-cov-2 semen |
| url | https://celljournal.org/journal/article/fulltext/possible-male-reproduction-complications-after-coronavirus-disease-20199.pdf |
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