Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance
Abstract Background Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting many organs, including the testis. Naringin from orange peel extract (OPE) is a flavanone with fertility-enhancing properties. Hence, this study was designed to establish the effect of naringin on T2DM-induced test...
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| Format: | Article |
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BMC
2024-02-01
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| Series: | Laboratory Animal Research |
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| Online Access: | https://doi.org/10.1186/s42826-024-00188-5 |
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| author | Kazeem Bidemi Okesina Adeyemi Fatai Odetayo Wale Johnson Adeyemi Ayodeji Johnson Ajibare Akeem Ayodeji Okesina Luqman Aribidesi Olayaki |
| author_facet | Kazeem Bidemi Okesina Adeyemi Fatai Odetayo Wale Johnson Adeyemi Ayodeji Johnson Ajibare Akeem Ayodeji Okesina Luqman Aribidesi Olayaki |
| author_sort | Kazeem Bidemi Okesina |
| collection | DOAJ |
| description | Abstract Background Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting many organs, including the testis. Naringin from orange peel extract (OPE) is a flavanone with fertility-enhancing properties. Hence, this study was designed to establish the effect of naringin on T2DM-induced testicular dysfunction. Thirty male (30) Wistar rats were randomized into five groups control, diabetes, diabetes + naringin, diabetes + OPE, and diabetes + metformin. The administrations were via the oral route and lasted for 28 days. Results Naringin ameliorated T2DM-induced increase in FBS and decrease in serum insulin. It also abrogated T2DM-induced decrease in sperm quality, gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol, prolactin, catalase, superoxide dismutase, and total antioxidant capacity. Furthermore, naringin prevented a T2DM-induced increase in malonaldehyde, tumor necrosis factor-alpha, C-reactive protein, xanthine oxidase (XO), and uric acid (UA), it was accompanied by the restoration of normal testicular histoarchitecture. Conclusions Naringin prevented T2DM-induced testicular dysfunction by modulating XO/UA and restoring redox balance. Also, while the animals treated with OPE exhibited better ameliorative effects than their counterparts treated with naringin, the findings from this study showed that naringin would be a promising supplement for treating T2DM-induced male infertility. |
| first_indexed | 2024-03-07T15:22:58Z |
| format | Article |
| id | doaj.art-74d647a0de8641d08c49555886c2ebea |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-07T15:22:58Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Laboratory Animal Research |
| spelling | doaj.art-74d647a0de8641d08c49555886c2ebea2024-03-05T17:33:21ZengBMCLaboratory Animal Research2233-76602024-02-0140111010.1186/s42826-024-00188-5Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balanceKazeem Bidemi Okesina0Adeyemi Fatai Odetayo1Wale Johnson Adeyemi2Ayodeji Johnson Ajibare3Akeem Ayodeji Okesina4Luqman Aribidesi Olayaki5Department of Medical Physiology, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of RwandaDepartment of Physiology, Federal University of Health SciencesDepartment of Physiology, Adeleke UniversityDepartment of Physiology, Lead City UniversityDepartment of Clinical Medicine and Community Health, School of Health Sciences, College of Medicine and Health Sciences, University of RwandaDepartment of Physiology, University of IlorinAbstract Background Type 2 diabetes mellitus (T2DM) is a metabolic disorder affecting many organs, including the testis. Naringin from orange peel extract (OPE) is a flavanone with fertility-enhancing properties. Hence, this study was designed to establish the effect of naringin on T2DM-induced testicular dysfunction. Thirty male (30) Wistar rats were randomized into five groups control, diabetes, diabetes + naringin, diabetes + OPE, and diabetes + metformin. The administrations were via the oral route and lasted for 28 days. Results Naringin ameliorated T2DM-induced increase in FBS and decrease in serum insulin. It also abrogated T2DM-induced decrease in sperm quality, gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol, prolactin, catalase, superoxide dismutase, and total antioxidant capacity. Furthermore, naringin prevented a T2DM-induced increase in malonaldehyde, tumor necrosis factor-alpha, C-reactive protein, xanthine oxidase (XO), and uric acid (UA), it was accompanied by the restoration of normal testicular histoarchitecture. Conclusions Naringin prevented T2DM-induced testicular dysfunction by modulating XO/UA and restoring redox balance. Also, while the animals treated with OPE exhibited better ameliorative effects than their counterparts treated with naringin, the findings from this study showed that naringin would be a promising supplement for treating T2DM-induced male infertility.https://doi.org/10.1186/s42826-024-00188-5Testicular dysfunctionXanthine oxidase/uric acid signalingRedox balanceDiabetes mellitusNaringinOrange peel ethanolic extract |
| spellingShingle | Kazeem Bidemi Okesina Adeyemi Fatai Odetayo Wale Johnson Adeyemi Ayodeji Johnson Ajibare Akeem Ayodeji Okesina Luqman Aribidesi Olayaki Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance Laboratory Animal Research Testicular dysfunction Xanthine oxidase/uric acid signaling Redox balance Diabetes mellitus Naringin Orange peel ethanolic extract |
| title | Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance |
| title_full | Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance |
| title_fullStr | Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance |
| title_full_unstemmed | Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance |
| title_short | Naringin from sweet orange peel improves testicular function in high fat diet-induced diabetic rats by modulating xanthine oxidase/uric acid signaling and maintaining redox balance |
| title_sort | naringin from sweet orange peel improves testicular function in high fat diet induced diabetic rats by modulating xanthine oxidase uric acid signaling and maintaining redox balance |
| topic | Testicular dysfunction Xanthine oxidase/uric acid signaling Redox balance Diabetes mellitus Naringin Orange peel ethanolic extract |
| url | https://doi.org/10.1186/s42826-024-00188-5 |
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