Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trial
Abstract Background Progress in vitrification techniques has allowed reproductive physicians to consider new strategies for using progestin as an alternative to a GnRH analogue to improve in vitro fertilisation (IVF). However, the role of progestin in blocking luteinising hormone (LH) surges and its...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | Trials |
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| Online Access: | http://link.springer.com/article/10.1186/s13063-018-2850-x |
| _version_ | 1818331143620001792 |
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| author | Yun Wang Yanping Kuang Qiuju Chen Renfei Cai |
| author_facet | Yun Wang Yanping Kuang Qiuju Chen Renfei Cai |
| author_sort | Yun Wang |
| collection | DOAJ |
| description | Abstract Background Progress in vitrification techniques has allowed reproductive physicians to consider new strategies for using progestin as an alternative to a GnRH analogue to improve in vitro fertilisation (IVF). However, the role of progestin in blocking luteinising hormone (LH) surges and its potential in clinical practice are unclear, especially for poor responders. We designed a prospective randomised controlled trial (RCT) to compare the efficacy of a gonadotropin-releasing hormone (GnRH) antagonist and progestin in blocking LH surges and premature ovulation in poor responders. Methods/design Poor responders who meet the Bologna criteria will be randomised to one of two stimulation regimens—gonadotropin-releasing hormone (GnRH) antagonist or progestin-primed ovarian stimulation (PPOS)—using a computer-generated random number. Fresh embryos were transferred in the GnRH antagonist group and frozen embryos were transferred in the PPOS group. The primary outcome is the incidence of premature LH surges. Secondary outcomes include the number of oocytes retrieved, the number of embryos available for transfer, implantation rates and clinical pregnancy. The sample size for this trial is estimated as 340 participants, with 170 participants in each group. The data analysis will be by intention to treat. Discussion To our knowledge, this is the first RCT to examine the efficacy of administering progestin orally to block LH surges and premature ovulation compared with the GnRH antagonist protocols in poor responders undergoing IVF treatment. Trial registration www.chictr.org.cn. ChiCTR-IPR-17010906. Registered on 18 March 2017. |
| first_indexed | 2024-12-13T13:15:10Z |
| format | Article |
| id | doaj.art-74d66e3c9b934d5f81aea1b00703501b |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-13T13:15:10Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-74d66e3c9b934d5f81aea1b00703501b2022-12-21T23:44:33ZengBMCTrials1745-62152018-08-011911610.1186/s13063-018-2850-xGonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trialYun Wang0Yanping Kuang1Qiuju Chen2Renfei Cai3Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of MedicineDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of MedicineDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of MedicineDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of MedicineAbstract Background Progress in vitrification techniques has allowed reproductive physicians to consider new strategies for using progestin as an alternative to a GnRH analogue to improve in vitro fertilisation (IVF). However, the role of progestin in blocking luteinising hormone (LH) surges and its potential in clinical practice are unclear, especially for poor responders. We designed a prospective randomised controlled trial (RCT) to compare the efficacy of a gonadotropin-releasing hormone (GnRH) antagonist and progestin in blocking LH surges and premature ovulation in poor responders. Methods/design Poor responders who meet the Bologna criteria will be randomised to one of two stimulation regimens—gonadotropin-releasing hormone (GnRH) antagonist or progestin-primed ovarian stimulation (PPOS)—using a computer-generated random number. Fresh embryos were transferred in the GnRH antagonist group and frozen embryos were transferred in the PPOS group. The primary outcome is the incidence of premature LH surges. Secondary outcomes include the number of oocytes retrieved, the number of embryos available for transfer, implantation rates and clinical pregnancy. The sample size for this trial is estimated as 340 participants, with 170 participants in each group. The data analysis will be by intention to treat. Discussion To our knowledge, this is the first RCT to examine the efficacy of administering progestin orally to block LH surges and premature ovulation compared with the GnRH antagonist protocols in poor responders undergoing IVF treatment. Trial registration www.chictr.org.cn. ChiCTR-IPR-17010906. Registered on 18 March 2017.http://link.springer.com/article/10.1186/s13063-018-2850-xGnRH antagonistProgestinPoor respondersLH surge |
| spellingShingle | Yun Wang Yanping Kuang Qiuju Chen Renfei Cai Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trial Trials GnRH antagonist Progestin Poor responders LH surge |
| title | Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trial |
| title_full | Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trial |
| title_fullStr | Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trial |
| title_full_unstemmed | Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trial |
| title_short | Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trial |
| title_sort | gonadotropin releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment study protocol for a randomised controlled trial |
| topic | GnRH antagonist Progestin Poor responders LH surge |
| url | http://link.springer.com/article/10.1186/s13063-018-2850-x |
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