Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism

Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism

Mutations in the SHANK family of genes have been consistently identified in genetic and genomic screens of autism spectrum disorder (ASD). The functional overlap of SHANK with several other ASD-associated genes suggests synaptic dysfunction as a convergent mechanism of pathophysiology in ASD. Althou...

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Bibliographic Details
Main Authors: Meera E. Modi, Julie M. Brooks, Edward R. Guilmette, Mercedes Beyna, Radka Graf, Dominik Reim, Michael J. Schmeisser, Tobias M. Boeckers, Patricio O’Donnell, Derek L. Buhl
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
SHANK
Shank2
autism spectrum disorders
rat model
mGluR
motivation
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00107/full

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