Potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100ß upregulation in non-thrombolysis patient
Introduction: In ischemic stroke, the cerebral cortex suffers from hypoxia-ischemia, leading to inflammation and oxidative stress. Green tea extract has an anti-inflammation effect and antioxidant. This study aimed to determine the efficacy of green tea extract for adjuvant treatment of acute isch...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2023-06-01
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| Series: | Jurnal Ners |
| Online Access: | https://e-journal.unair.ac.id/JNERS/article/view/45537 |
| _version_ | 1797743724940230656 |
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| author | Abdulloh Machin Djoko Agus Suprapto Anny Hanifah Isti Suharjanti Jakfar Shodiq M Fata Fatihuddin Beom Joon Kim Azizah Amimathul Firdha |
| author_facet | Abdulloh Machin Djoko Agus Suprapto Anny Hanifah Isti Suharjanti Jakfar Shodiq M Fata Fatihuddin Beom Joon Kim Azizah Amimathul Firdha |
| author_sort | Abdulloh Machin |
| collection | DOAJ |
| description | Introduction: In ischemic stroke, the cerebral cortex suffers from hypoxia-ischemia, leading to inflammation and
oxidative stress. Green tea extract has an anti-inflammation effect and antioxidant. This study aimed to determine
the efficacy of green tea extract for adjuvant treatment of acute ischemic stroke in non-thrombolysis patients.
Methods: A double-blind randomised controlled trial was conducted in November 2020-November 2021. The
subjects were all acute ischemic stroke patients who presented to the Emergency Room during recruitment,
randomised into control (n=13) and intervention groups (n=18); the intervention groups were given green tea extract
350 mg. Treatment was for 30 days. National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS),
Montreal Cognitive Assessment - Indonesia (MoCAIna), IL-10 and S100ß were analysed.
Results: Data were compared with a significance level of p<0.05. The differences in NIHSS from day 0 to 7, day 0 to
14 and day 0 to 30 were statistically significant in the intervention group (p=0.019, p=0.002 and p=0.000, respectively).
The mRS score was statistically significant in the intervention group on day 30 (p=0.46). The differences in mRS score
from day 0 to 14 and day 0 to 30 were statistically significant (p=0.042 and p=0.001, respectively) The S100ß were
statistically significant in day 7 (p=0.006). The difference in S100ß from day 0 to 7 was statistically significant (p=0.001).Conclusions: The green tea extract, through up-regulation S100ß, can improve the clinical outcomes of acute
ischemic stroke. |
| first_indexed | 2024-03-12T15:00:30Z |
| format | Article |
| id | doaj.art-74d7ba38b54a42b48593bb71e7e90a2e |
| institution | Directory Open Access Journal |
| issn | 1858-3598 2502-5791 |
| language | English |
| last_indexed | 2024-03-12T15:00:30Z |
| publishDate | 2023-06-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Jurnal Ners |
| spelling | doaj.art-74d7ba38b54a42b48593bb71e7e90a2e2023-08-14T08:55:37ZengUniversitas AirlanggaJurnal Ners1858-35982502-57912023-06-0118214515310.20473/jn.v18i2.4553743622Potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100ß upregulation in non-thrombolysis patientAbdulloh Machin0https://orcid.org/0000-0003-0369-0898Djoko Agus Suprapto1Anny Hanifah2https://orcid.org/0000-0002-4747-3150Isti Suharjanti3https://orcid.org/0009-0008-5916-3126Jakfar Shodiq4M Fata Fatihuddin5Beom Joon Kim6https://orcid.org/0000-0002-2719-3012Azizah Amimathul Firdha7https://orcid.org/0000-0002-5584-7570Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaFaculty of Pharmacy, Universitas Airlangga, Surabaya, IndonesiaFaculty of Medicine, Universitas Hang Tuah, Surabaya, IndonesiaFaculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaIndonesian Medical Association (IDI) Pamekasan, Pamekasan, IndonesiaFaculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaSeoul National University, Bundang Hospital, Seoul, South KoreaIndonesian Medical Association (IDI) Surabaya, Surabaya, IndonesiaIntroduction: In ischemic stroke, the cerebral cortex suffers from hypoxia-ischemia, leading to inflammation and oxidative stress. Green tea extract has an anti-inflammation effect and antioxidant. This study aimed to determine the efficacy of green tea extract for adjuvant treatment of acute ischemic stroke in non-thrombolysis patients. Methods: A double-blind randomised controlled trial was conducted in November 2020-November 2021. The subjects were all acute ischemic stroke patients who presented to the Emergency Room during recruitment, randomised into control (n=13) and intervention groups (n=18); the intervention groups were given green tea extract 350 mg. Treatment was for 30 days. National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), Montreal Cognitive Assessment - Indonesia (MoCAIna), IL-10 and S100ß were analysed. Results: Data were compared with a significance level of p<0.05. The differences in NIHSS from day 0 to 7, day 0 to 14 and day 0 to 30 were statistically significant in the intervention group (p=0.019, p=0.002 and p=0.000, respectively). The mRS score was statistically significant in the intervention group on day 30 (p=0.46). The differences in mRS score from day 0 to 14 and day 0 to 30 were statistically significant (p=0.042 and p=0.001, respectively) The S100ß were statistically significant in day 7 (p=0.006). The difference in S100ß from day 0 to 7 was statistically significant (p=0.001).Conclusions: The green tea extract, through up-regulation S100ß, can improve the clinical outcomes of acute ischemic stroke.https://e-journal.unair.ac.id/JNERS/article/view/45537 |
| spellingShingle | Abdulloh Machin Djoko Agus Suprapto Anny Hanifah Isti Suharjanti Jakfar Shodiq M Fata Fatihuddin Beom Joon Kim Azizah Amimathul Firdha Potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100ß upregulation in non-thrombolysis patient Jurnal Ners |
| title | Potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100ß upregulation in non-thrombolysis patient |
| title_full | Potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100ß upregulation in non-thrombolysis patient |
| title_fullStr | Potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100ß upregulation in non-thrombolysis patient |
| title_full_unstemmed | Potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100ß upregulation in non-thrombolysis patient |
| title_short | Potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100ß upregulation in non-thrombolysis patient |
| title_sort | potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100ss upregulation in non thrombolysis patient |
| url | https://e-journal.unair.ac.id/JNERS/article/view/45537 |
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