Pain modulation in the spinal cord
The sensory inflow from the periphery that triggers innocuous and painful sensations is highly complex, capturing key elements of the nature of any stimulus, its location, intensity, and duration, and converting this to dynamic action potential firing across a wide population of afferents. While sen...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Pain Research |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2022.984042/full |
| _version_ | 1811211412496711680 |
|---|---|
| author | Clifford J. Woolf |
| author_facet | Clifford J. Woolf |
| author_sort | Clifford J. Woolf |
| collection | DOAJ |
| description | The sensory inflow from the periphery that triggers innocuous and painful sensations is highly complex, capturing key elements of the nature of any stimulus, its location, intensity, and duration, and converting this to dynamic action potential firing across a wide population of afferents. While sensory afferents are highly specialized to detect these features, their input to the spinal cord also triggers active processing and modulation there which determines its output, to drive the sensory percept experienced and behavioral responses. Focus on such active spinal modulation was arguably first introduced by Melzack and Wall in their Spinal Cord Gate Control theory. This theory has had a profound influence on our understanding of pain, and especially its processing, as well as leading directly to the development of clinical interventions, and its historical importance certainly needs to be fully recognized. However, the enormous progress we are making in the understanding of the function of the somatosensory system, means that it is time to incorporate these newly discovered features into a more complex and accurate model of spinal sensory modulation. |
| first_indexed | 2024-04-12T05:12:34Z |
| format | Article |
| id | doaj.art-74d8fcbe9d4a4e8092c7dfa8a13a105f |
| institution | Directory Open Access Journal |
| issn | 2673-561X |
| language | English |
| last_indexed | 2024-04-12T05:12:34Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj.art-74d8fcbe9d4a4e8092c7dfa8a13a105f2022-12-22T03:46:43ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2022-09-01310.3389/fpain.2022.984042984042Pain modulation in the spinal cordClifford J. WoolfThe sensory inflow from the periphery that triggers innocuous and painful sensations is highly complex, capturing key elements of the nature of any stimulus, its location, intensity, and duration, and converting this to dynamic action potential firing across a wide population of afferents. While sensory afferents are highly specialized to detect these features, their input to the spinal cord also triggers active processing and modulation there which determines its output, to drive the sensory percept experienced and behavioral responses. Focus on such active spinal modulation was arguably first introduced by Melzack and Wall in their Spinal Cord Gate Control theory. This theory has had a profound influence on our understanding of pain, and especially its processing, as well as leading directly to the development of clinical interventions, and its historical importance certainly needs to be fully recognized. However, the enormous progress we are making in the understanding of the function of the somatosensory system, means that it is time to incorporate these newly discovered features into a more complex and accurate model of spinal sensory modulation.https://www.frontiersin.org/articles/10.3389/fpain.2022.984042/fullpainspinal cordgate control theoryinhibitionpresynaptic |
| spellingShingle | Clifford J. Woolf Pain modulation in the spinal cord Frontiers in Pain Research pain spinal cord gate control theory inhibition presynaptic |
| title | Pain modulation in the spinal cord |
| title_full | Pain modulation in the spinal cord |
| title_fullStr | Pain modulation in the spinal cord |
| title_full_unstemmed | Pain modulation in the spinal cord |
| title_short | Pain modulation in the spinal cord |
| title_sort | pain modulation in the spinal cord |
| topic | pain spinal cord gate control theory inhibition presynaptic |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2022.984042/full |
| work_keys_str_mv | AT cliffordjwoolf painmodulationinthespinalcord |