A correlation between Magnetic Resonance Spectroscopy (1-H MRS) and the neurodevelopment of two-year-olds born preterm in an EPIRMEX cohort study
BackgroundPreterm infants are at risk of neurodevelopmental impairments. At present, proton magnetic resonance spectroscopy (1H-MRS) is currently used to evaluate brain metabolites in asphyxiated term infants. The purpose of this study was to identify in the preterm EPIRMEX cohort any correlations b...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.936130/full |
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| author | Catherine Gire Catherine Gire Julie Berbis Marion Dequin Stéphane Marret Jean-Baptiste Muller Elie Saliba Barthélémy Tosello Barthélémy Tosello |
| author_facet | Catherine Gire Catherine Gire Julie Berbis Marion Dequin Stéphane Marret Jean-Baptiste Muller Elie Saliba Barthélémy Tosello Barthélémy Tosello |
| author_sort | Catherine Gire |
| collection | DOAJ |
| description | BackgroundPreterm infants are at risk of neurodevelopmental impairments. At present, proton magnetic resonance spectroscopy (1H-MRS) is currently used to evaluate brain metabolites in asphyxiated term infants. The purpose of this study was to identify in the preterm EPIRMEX cohort any correlations between (1H-MRS) metabolites ratio at term equivalent age (TEA) and neurodevelopmental outcomes at 2 years.MethodsOur study included EPIRMEX eligible patients who were very preterm infants (gestational age at birth ≤32 weeks) and who underwent a brain MRI at TEA and 1H-MRS using a monovoxel technique. The volumes of interest (VOI) were periventricular white matter posterior area and basal ganglia. The ratio of N Acetyl Aspartate (NAA) to Cho (Choline), NAA to Cr (creatine), Cho to Cr, and Lac (Lactate) to Cr were measured. Neurodevelopment was assessed at 24 months TEA with ASQ (Ages and Stages Questionnaire).ResultsA total of 69 very preterm infants had a 1H-MRS at TEA. In white matter there was a significant correlation between a reduction in the NAA/Cho ratio and a total ASQ and/or abnormal communication score, and an increase in the Lac/Cr ratio and an abnormality of fine motor skills. In the gray nuclei there was a trend correlation between the reduction in the NAA/Cho ratio and sociability disorders; and the increase in the Lac/Cr ratio and an anomaly in problem-solving.ConclusionsUsing NAA as a biomarker, the vulnerability of immature oligodendrocytes in preterm children at TEA was correlated to neurodevelopment at 2 years. Similarly, the presence of lactate at TEA was associated with abnormal neurodevelopment at 2 years in the preterm brain. |
| first_indexed | 2024-04-13T02:21:59Z |
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| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-13T02:21:59Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-74da34e219964d428c372014b69bb25e2022-12-22T03:06:55ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-08-011010.3389/fped.2022.936130936130A correlation between Magnetic Resonance Spectroscopy (1-H MRS) and the neurodevelopment of two-year-olds born preterm in an EPIRMEX cohort studyCatherine Gire0Catherine Gire1Julie Berbis2Marion Dequin3Stéphane Marret4Jean-Baptiste Muller5Elie Saliba6Barthélémy Tosello7Barthélémy Tosello8Department of Neonatal Medicine, Assistance Publique Hopitaux de Marseille, Marseille, FranceEA3279, Faculty of Medicine, Self-Perceived Health Assessment Research Unit, Marseille, FranceEA3279, Faculty of Medicine, Self-Perceived Health Assessment Research Unit, Marseille, FranceDepartment of Neonatal Pediatrics, Intensive Care, and Neuropediatrics, Rouen University Hospital and Institut National de la Santé et de la Recherche Médicale INSERM U 1245 Team 4 Neovasc, School of Medicine, Normandy University, Rouen, FranceDepartment of Neonatal Pediatrics, Intensive Care, and Neuropediatrics, Rouen University Hospital and Institut National de la Santé et de la Recherche Médicale INSERM U 1245 Team 4 Neovasc, School of Medicine, Normandy University, Rouen, FranceDepartment of Neonatal Medicine, Nantes University Hospital, Nantes, FranceUMR 1253, iBrain, Tours University, Institut National de la Santé et de la Recherche Médicale (INSERM), Tours, FranceDepartment of Neonatal Medicine, Assistance Publique Hopitaux de Marseille, Marseille, FranceAix-Marseille University, CNRS, EFS, ADES, Marseille, FranceBackgroundPreterm infants are at risk of neurodevelopmental impairments. At present, proton magnetic resonance spectroscopy (1H-MRS) is currently used to evaluate brain metabolites in asphyxiated term infants. The purpose of this study was to identify in the preterm EPIRMEX cohort any correlations between (1H-MRS) metabolites ratio at term equivalent age (TEA) and neurodevelopmental outcomes at 2 years.MethodsOur study included EPIRMEX eligible patients who were very preterm infants (gestational age at birth ≤32 weeks) and who underwent a brain MRI at TEA and 1H-MRS using a monovoxel technique. The volumes of interest (VOI) were periventricular white matter posterior area and basal ganglia. The ratio of N Acetyl Aspartate (NAA) to Cho (Choline), NAA to Cr (creatine), Cho to Cr, and Lac (Lactate) to Cr were measured. Neurodevelopment was assessed at 24 months TEA with ASQ (Ages and Stages Questionnaire).ResultsA total of 69 very preterm infants had a 1H-MRS at TEA. In white matter there was a significant correlation between a reduction in the NAA/Cho ratio and a total ASQ and/or abnormal communication score, and an increase in the Lac/Cr ratio and an abnormality of fine motor skills. In the gray nuclei there was a trend correlation between the reduction in the NAA/Cho ratio and sociability disorders; and the increase in the Lac/Cr ratio and an anomaly in problem-solving.ConclusionsUsing NAA as a biomarker, the vulnerability of immature oligodendrocytes in preterm children at TEA was correlated to neurodevelopment at 2 years. Similarly, the presence of lactate at TEA was associated with abnormal neurodevelopment at 2 years in the preterm brain.https://www.frontiersin.org/articles/10.3389/fped.2022.936130/fullneurodevelopmental outcomemagnetic resonance spectroscopyvery preterm infantmorbidity2 years follow-up |
| spellingShingle | Catherine Gire Catherine Gire Julie Berbis Marion Dequin Stéphane Marret Jean-Baptiste Muller Elie Saliba Barthélémy Tosello Barthélémy Tosello A correlation between Magnetic Resonance Spectroscopy (1-H MRS) and the neurodevelopment of two-year-olds born preterm in an EPIRMEX cohort study Frontiers in Pediatrics neurodevelopmental outcome magnetic resonance spectroscopy very preterm infant morbidity 2 years follow-up |
| title | A correlation between Magnetic Resonance Spectroscopy (1-H MRS) and the neurodevelopment of two-year-olds born preterm in an EPIRMEX cohort study |
| title_full | A correlation between Magnetic Resonance Spectroscopy (1-H MRS) and the neurodevelopment of two-year-olds born preterm in an EPIRMEX cohort study |
| title_fullStr | A correlation between Magnetic Resonance Spectroscopy (1-H MRS) and the neurodevelopment of two-year-olds born preterm in an EPIRMEX cohort study |
| title_full_unstemmed | A correlation between Magnetic Resonance Spectroscopy (1-H MRS) and the neurodevelopment of two-year-olds born preterm in an EPIRMEX cohort study |
| title_short | A correlation between Magnetic Resonance Spectroscopy (1-H MRS) and the neurodevelopment of two-year-olds born preterm in an EPIRMEX cohort study |
| title_sort | correlation between magnetic resonance spectroscopy 1 h mrs and the neurodevelopment of two year olds born preterm in an epirmex cohort study |
| topic | neurodevelopmental outcome magnetic resonance spectroscopy very preterm infant morbidity 2 years follow-up |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.936130/full |
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