Arterial Hypertension: Individual Therapeutic Approaches—From DNA Sequencing to Gender Differentiation and New Therapeutic Targets
The aim of this paper is to provide an accurate overview regarding the current recommended approach for antihypertensive treatment. The importance of DNA sequencing in understanding the complex implication of genetics in hypertension could represent an important step in understanding antihypertensiv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/6/856 |
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| author | Constantin-Tudor Luca Simina Crisan Dragos Cozma Alina Negru Mihai-Andrei Lazar Cristina Vacarescu Mihai Trofenciuc Ciprian Rachieru Laura Maria Craciun Dan Gaita Lucian Petrescu Alexandru Mischie Stela Iurciuc |
| author_facet | Constantin-Tudor Luca Simina Crisan Dragos Cozma Alina Negru Mihai-Andrei Lazar Cristina Vacarescu Mihai Trofenciuc Ciprian Rachieru Laura Maria Craciun Dan Gaita Lucian Petrescu Alexandru Mischie Stela Iurciuc |
| author_sort | Constantin-Tudor Luca |
| collection | DOAJ |
| description | The aim of this paper is to provide an accurate overview regarding the current recommended approach for antihypertensive treatment. The importance of DNA sequencing in understanding the complex implication of genetics in hypertension could represent an important step in understanding antihypertensive treatment as well as in developing new medical strategies. Despite a pool of data from studies regarding cardiovascular risk factors emphasizing a worse prognosis for female patients rather than male patients, there are also results indicating that women are more likely to be predisposed to the use of antihypertensive medication and less likely to develop uncontrolled hypertension. Moreover, lower systolic blood pressure values are associated with increased cardiovascular risk in women compared to men. The prevalence, awareness and, most importantly, treatment of hypertension is variable in male and female patients, since the mechanisms responsible for this pathology may be different and closely related to gender factors such as the renin–angiotensin system, sympathetic nervous activity, endothelin-1, sex hormones, aldosterone, and the immune system. Thus, gender-related antihypertensive treatment individualization may be a valuable tool in improving female patients’ prognosis. |
| first_indexed | 2024-03-10T10:35:13Z |
| format | Article |
| id | doaj.art-74e025effc1448dca57463debf7a8d2f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T10:35:13Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-74e025effc1448dca57463debf7a8d2f2023-11-21T23:22:25ZengMDPI AGPharmaceutics1999-49232021-06-0113685610.3390/pharmaceutics13060856Arterial Hypertension: Individual Therapeutic Approaches—From DNA Sequencing to Gender Differentiation and New Therapeutic TargetsConstantin-Tudor Luca0Simina Crisan1Dragos Cozma2Alina Negru3Mihai-Andrei Lazar4Cristina Vacarescu5Mihai Trofenciuc6Ciprian Rachieru7Laura Maria Craciun8Dan Gaita9Lucian Petrescu10Alexandru Mischie11Stela Iurciuc12Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Cardiology, “Vasile Goldis” Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaInvasive Cardiology Unit, Centre Hospitalier de Montluçon, 03100 Montluçon, FranceDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, RomaniaThe aim of this paper is to provide an accurate overview regarding the current recommended approach for antihypertensive treatment. The importance of DNA sequencing in understanding the complex implication of genetics in hypertension could represent an important step in understanding antihypertensive treatment as well as in developing new medical strategies. Despite a pool of data from studies regarding cardiovascular risk factors emphasizing a worse prognosis for female patients rather than male patients, there are also results indicating that women are more likely to be predisposed to the use of antihypertensive medication and less likely to develop uncontrolled hypertension. Moreover, lower systolic blood pressure values are associated with increased cardiovascular risk in women compared to men. The prevalence, awareness and, most importantly, treatment of hypertension is variable in male and female patients, since the mechanisms responsible for this pathology may be different and closely related to gender factors such as the renin–angiotensin system, sympathetic nervous activity, endothelin-1, sex hormones, aldosterone, and the immune system. Thus, gender-related antihypertensive treatment individualization may be a valuable tool in improving female patients’ prognosis.https://www.mdpi.com/1999-4923/13/6/856arterial hypertensionDNA sequencinggender differentiation of response to antihypertensive treatmentindividual therapeutic approach |
| spellingShingle | Constantin-Tudor Luca Simina Crisan Dragos Cozma Alina Negru Mihai-Andrei Lazar Cristina Vacarescu Mihai Trofenciuc Ciprian Rachieru Laura Maria Craciun Dan Gaita Lucian Petrescu Alexandru Mischie Stela Iurciuc Arterial Hypertension: Individual Therapeutic Approaches—From DNA Sequencing to Gender Differentiation and New Therapeutic Targets Pharmaceutics arterial hypertension DNA sequencing gender differentiation of response to antihypertensive treatment individual therapeutic approach |
| title | Arterial Hypertension: Individual Therapeutic Approaches—From DNA Sequencing to Gender Differentiation and New Therapeutic Targets |
| title_full | Arterial Hypertension: Individual Therapeutic Approaches—From DNA Sequencing to Gender Differentiation and New Therapeutic Targets |
| title_fullStr | Arterial Hypertension: Individual Therapeutic Approaches—From DNA Sequencing to Gender Differentiation and New Therapeutic Targets |
| title_full_unstemmed | Arterial Hypertension: Individual Therapeutic Approaches—From DNA Sequencing to Gender Differentiation and New Therapeutic Targets |
| title_short | Arterial Hypertension: Individual Therapeutic Approaches—From DNA Sequencing to Gender Differentiation and New Therapeutic Targets |
| title_sort | arterial hypertension individual therapeutic approaches from dna sequencing to gender differentiation and new therapeutic targets |
| topic | arterial hypertension DNA sequencing gender differentiation of response to antihypertensive treatment individual therapeutic approach |
| url | https://www.mdpi.com/1999-4923/13/6/856 |
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