Immune Response Visualized In Vivo by [18F]-FDG PET/CT after COVID-19 Vaccine
Worldwide deployment of COVID-19 vaccines is in progress. Recent immune activation following vaccination can sometimes be seen in fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ([18F]-FDG PET/CT). As previously evidenced, FDG-avid axillary lymph node(s) are common in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/4/676 |
| _version_ | 1827695564325650432 |
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| author | Romain-David Seban Laurence Champion Nicolas Deleval Capucine Richard Claire Provost |
| author_facet | Romain-David Seban Laurence Champion Nicolas Deleval Capucine Richard Claire Provost |
| author_sort | Romain-David Seban |
| collection | DOAJ |
| description | Worldwide deployment of COVID-19 vaccines is in progress. Recent immune activation following vaccination can sometimes be seen in fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ([18F]-FDG PET/CT). As previously evidenced, FDG-avid axillary lymph node(s) are common in patients receiving vaccines against SARS-CoV-2, influenza virus, or human papillomavirus, and reflect a regional immune response. In addition, these findings may also be accompanied by an increased spleen glucose metabolism after the COVID-19 vaccine, which captures a systemic immune response. Hence, we provide here a clinical example demonstrating that immune response could be associated with increased glucose metabolism in lymphoid organs such as lymph nodes and the spleen, which are critical modulators of T cell immunity. We believe that it is of paramount importance that nuclear physicians should be able to recognize clinical and imaging features of such immune responses upon vaccination for COVID-19 and beyond. |
| first_indexed | 2024-03-10T12:29:01Z |
| format | Article |
| id | doaj.art-74e2b4682d8a4715a10124ff8f9f5f16 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T12:29:01Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-74e2b4682d8a4715a10124ff8f9f5f162023-11-21T14:50:41ZengMDPI AGDiagnostics2075-44182021-04-0111467610.3390/diagnostics11040676Immune Response Visualized In Vivo by [18F]-FDG PET/CT after COVID-19 VaccineRomain-David Seban0Laurence Champion1Nicolas Deleval2Capucine Richard3Claire Provost4Department of Nuclear Medicine and Endocrine Oncology, Institut Curie, 92210 Saint-Cloud, FranceDepartment of Nuclear Medicine and Endocrine Oncology, Institut Curie, 92210 Saint-Cloud, FranceDepartment of Nuclear Medicine and Endocrine Oncology, Institut Curie, 92210 Saint-Cloud, FranceDepartment of Nuclear Medicine and Endocrine Oncology, Institut Curie, 92210 Saint-Cloud, FranceLaboratoire d’Imagerie Translationnelle en Oncologie, Inserm, Institut Curie, 91401 Orsay, FranceWorldwide deployment of COVID-19 vaccines is in progress. Recent immune activation following vaccination can sometimes be seen in fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ([18F]-FDG PET/CT). As previously evidenced, FDG-avid axillary lymph node(s) are common in patients receiving vaccines against SARS-CoV-2, influenza virus, or human papillomavirus, and reflect a regional immune response. In addition, these findings may also be accompanied by an increased spleen glucose metabolism after the COVID-19 vaccine, which captures a systemic immune response. Hence, we provide here a clinical example demonstrating that immune response could be associated with increased glucose metabolism in lymphoid organs such as lymph nodes and the spleen, which are critical modulators of T cell immunity. We believe that it is of paramount importance that nuclear physicians should be able to recognize clinical and imaging features of such immune responses upon vaccination for COVID-19 and beyond.https://www.mdpi.com/2075-4418/11/4/676[18F]-FDG PET/CTCOVID-19 vaccinespleenlymph nodesimmune response |
| spellingShingle | Romain-David Seban Laurence Champion Nicolas Deleval Capucine Richard Claire Provost Immune Response Visualized In Vivo by [18F]-FDG PET/CT after COVID-19 Vaccine Diagnostics [18F]-FDG PET/CT COVID-19 vaccine spleen lymph nodes immune response |
| title | Immune Response Visualized In Vivo by [18F]-FDG PET/CT after COVID-19 Vaccine |
| title_full | Immune Response Visualized In Vivo by [18F]-FDG PET/CT after COVID-19 Vaccine |
| title_fullStr | Immune Response Visualized In Vivo by [18F]-FDG PET/CT after COVID-19 Vaccine |
| title_full_unstemmed | Immune Response Visualized In Vivo by [18F]-FDG PET/CT after COVID-19 Vaccine |
| title_short | Immune Response Visualized In Vivo by [18F]-FDG PET/CT after COVID-19 Vaccine |
| title_sort | immune response visualized in vivo by 18f fdg pet ct after covid 19 vaccine |
| topic | [18F]-FDG PET/CT COVID-19 vaccine spleen lymph nodes immune response |
| url | https://www.mdpi.com/2075-4418/11/4/676 |
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