HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation

HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation

Disregulation of fatty acid oxidation, one of the major mechanisms for maintaining hepatic lipid homeostasis under fasting conditions, leads to hepatic steatosis. Although obesity and type 2 diabetes-induced endoplasmic reticulum (ER) stress contribute to hepatic steatosis, it is largely unknown how...

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Bibliographic Details
Main Authors: Xinchen Qiu, Jian Li, Sihan Lv, Jiamin Yu, Junkun Jiang, Jindong Yao, Yang Xiao, Bingxin Xu, Haiyan He, Fangfei Guo, Zhen-Ning Zhang, Chao Zhang, Bing Luan
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Journal of Lipid Research
Subjects:
ER stress
HDAC5
PPARα
fatty acid oxidation
fasting signal
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520342358

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