Burden of atrial fibrillation among adults with heart failure in sub-Saharan Africa: a systematic review and meta-analysis
Objectives This study aimed to estimate the prevalence of atrial fibrillation (AF) in adults with heart failure (HF) and summarise the all-cause mortality ratio among adult patients with coexisting HF and AF in sub-Saharan Africa (SSA).Setting This was a systematic review and meta-analysis of cross-...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/10/e061618.full |
| _version_ | 1797986106628636672 |
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| author | Jean Jacques Noubiap Valirie Ndip Agbor Leopold Ndemnge Aminde Clarence Mvalo Mbanga Frank-Leonel Tianyi Larissa Pone Simo Anastase Dzudie Saint Just N Petnga Muchi Ditah Chobufo |
| author_facet | Jean Jacques Noubiap Valirie Ndip Agbor Leopold Ndemnge Aminde Clarence Mvalo Mbanga Frank-Leonel Tianyi Larissa Pone Simo Anastase Dzudie Saint Just N Petnga Muchi Ditah Chobufo |
| author_sort | Jean Jacques Noubiap |
| collection | DOAJ |
| description | Objectives This study aimed to estimate the prevalence of atrial fibrillation (AF) in adults with heart failure (HF) and summarise the all-cause mortality ratio among adult patients with coexisting HF and AF in sub-Saharan Africa (SSA).Setting This was a systematic review and meta-analysis of cross-sectional and cohort studies with primary data on the prevalence and incidence of AF among patients with HF and the all-cause mortality ratio among patients with HF and AF in SSA. We combined text words and MeSH terms to search MEDLINE, PubMed and Global Health Library through Ovid SP, African Journals Online and African Index Medicus from database inception to 10 November 2021. Random-effects meta-analysis was used to estimate pooled prevalence.Primary outcome measures The prevalence and incidence of AF among patients with HF, and the all-cause mortality ratio among patients with HF and AF.Results Twenty-seven of the 1902 records retrieved from database searches were included in the review, totalling 9987 patients with HF. The pooled prevalence of AF among patients with HF was 15.6% (95% CI 12.0% to 19.6%). At six months, the all-cause mortality was 18.4% (95% CI 13.1% to 23.6%) in a multinational registry and 67.7% (95% CI 51.1% to 74.3%) in one study in Tanzania. The one-year mortality was 48.6% (95% CI 32.5% to 64.7%) in a study in the Democratic Republic of Congo. We did not find any study reporting the incidence of AF in HF.Conclusion AF is common among patients with HF in SSA, and patients with AF and HF have poor survival. There is an urgent need for large-scale population-based prospective data to reliably estimate the prevalence, incidence and risk of mortality of AF among HF patients in SSA to better understand the burden of AF in patients with HF in the region.PROSPERO registration number CRD42018087564. |
| first_indexed | 2024-04-11T07:27:39Z |
| format | Article |
| id | doaj.art-74e51dcff4ba481a9f30d73161c586ad |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-11T07:27:39Z |
| publishDate | 2022-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-74e51dcff4ba481a9f30d73161c586ad2022-12-22T04:37:01ZengBMJ Publishing GroupBMJ Open2044-60552022-10-01121010.1136/bmjopen-2022-061618Burden of atrial fibrillation among adults with heart failure in sub-Saharan Africa: a systematic review and meta-analysisJean Jacques Noubiap0Valirie Ndip Agbor1Leopold Ndemnge Aminde2Clarence Mvalo Mbanga3Frank-Leonel Tianyi4Larissa Pone Simo5Anastase Dzudie6Saint Just N Petnga7Muchi Ditah Chobufo8Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia, University of Adelaide CHRD, Adelaide, South Australia, AustraliaNuffield Department of Population Health, University of Oxford, Oxford, UKSchool of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, AustraliaMankon Sub-divisional Hospital, Bamenda, North West Region, CameroonNuffield Department of Population Health, University of Oxford, Oxford, UKGeneral Practice, Dzeng Sub-divisional Hospital, Dzeng, Centre Region, CameroonCardiology and Cardiac Pacing Unit, Department of Medicine, Douala General Hospital, Douala, CameroonKousseri Regional Hospital, Far-North Regional Delegation for Health, Kousseri, CameroonDepartment of Cardiovascular Diseases Heart and Vascular Institute, West Virginia University, Morgantown, West Virginia, USAObjectives This study aimed to estimate the prevalence of atrial fibrillation (AF) in adults with heart failure (HF) and summarise the all-cause mortality ratio among adult patients with coexisting HF and AF in sub-Saharan Africa (SSA).Setting This was a systematic review and meta-analysis of cross-sectional and cohort studies with primary data on the prevalence and incidence of AF among patients with HF and the all-cause mortality ratio among patients with HF and AF in SSA. We combined text words and MeSH terms to search MEDLINE, PubMed and Global Health Library through Ovid SP, African Journals Online and African Index Medicus from database inception to 10 November 2021. Random-effects meta-analysis was used to estimate pooled prevalence.Primary outcome measures The prevalence and incidence of AF among patients with HF, and the all-cause mortality ratio among patients with HF and AF.Results Twenty-seven of the 1902 records retrieved from database searches were included in the review, totalling 9987 patients with HF. The pooled prevalence of AF among patients with HF was 15.6% (95% CI 12.0% to 19.6%). At six months, the all-cause mortality was 18.4% (95% CI 13.1% to 23.6%) in a multinational registry and 67.7% (95% CI 51.1% to 74.3%) in one study in Tanzania. The one-year mortality was 48.6% (95% CI 32.5% to 64.7%) in a study in the Democratic Republic of Congo. We did not find any study reporting the incidence of AF in HF.Conclusion AF is common among patients with HF in SSA, and patients with AF and HF have poor survival. There is an urgent need for large-scale population-based prospective data to reliably estimate the prevalence, incidence and risk of mortality of AF among HF patients in SSA to better understand the burden of AF in patients with HF in the region.PROSPERO registration number CRD42018087564.https://bmjopen.bmj.com/content/12/10/e061618.full |
| spellingShingle | Jean Jacques Noubiap Valirie Ndip Agbor Leopold Ndemnge Aminde Clarence Mvalo Mbanga Frank-Leonel Tianyi Larissa Pone Simo Anastase Dzudie Saint Just N Petnga Muchi Ditah Chobufo Burden of atrial fibrillation among adults with heart failure in sub-Saharan Africa: a systematic review and meta-analysis BMJ Open |
| title | Burden of atrial fibrillation among adults with heart failure in sub-Saharan Africa: a systematic review and meta-analysis |
| title_full | Burden of atrial fibrillation among adults with heart failure in sub-Saharan Africa: a systematic review and meta-analysis |
| title_fullStr | Burden of atrial fibrillation among adults with heart failure in sub-Saharan Africa: a systematic review and meta-analysis |
| title_full_unstemmed | Burden of atrial fibrillation among adults with heart failure in sub-Saharan Africa: a systematic review and meta-analysis |
| title_short | Burden of atrial fibrillation among adults with heart failure in sub-Saharan Africa: a systematic review and meta-analysis |
| title_sort | burden of atrial fibrillation among adults with heart failure in sub saharan africa a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/12/10/e061618.full |
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