Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine
Metabolite levels in peripheral body fluids can correlate with attack features in migraine patients, which underscores the potential of plasma metabolites as possible disease biomarkers. Migraine headache can be preceded by an aura that is caused by cortical spreading depolarization (CSD), a transie...
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MDPI AG
2022-03-01
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| author | Inge C. M. Loonen Isabelle Kohler Mohan Ghorasaini Martin Giera Arn M. J. M. van den Maagdenberg Oleg A. Mayboroda Else A. Tolner |
| author_facet | Inge C. M. Loonen Isabelle Kohler Mohan Ghorasaini Martin Giera Arn M. J. M. van den Maagdenberg Oleg A. Mayboroda Else A. Tolner |
| author_sort | Inge C. M. Loonen |
| collection | DOAJ |
| description | Metabolite levels in peripheral body fluids can correlate with attack features in migraine patients, which underscores the potential of plasma metabolites as possible disease biomarkers. Migraine headache can be preceded by an aura that is caused by cortical spreading depolarization (CSD), a transient wave of neuroglial depolarization. We previously identified plasma amino acid changes after CSD in familial hemiplegic migraine type 1 (FHM1) mutant mice that exhibit increased neuronal excitability and various migraine-related features. Here, we aimed to uncover lipid metabolic pathways affected by CSD, guided by findings on the involvement of lipids in hemiplegic migraine pathophysiology. Using targeted lipidomic analysis, we studied plasma lipid metabolite levels at different time points after CSD in wild-type and FHM1 mutant mice. Following CSD, the most prominent plasma lipid change concerned a transient increase in PGD<sub>2</sub>, which lasted longer in mutant mice. In wild-type mice only, levels of anti-inflammatory lipid mediators DPAn-3, EPA, ALA, and DHA were elevated 24 h following CSD compared to Sham-treated animals. Given the role of PGs and neuroinflammation in migraine pathophysiology, our findings underscore the potential of monitoring peripheral changes in lipids to gain insight in central brain mechanisms. |
| first_indexed | 2024-03-09T13:21:26Z |
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| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T13:21:26Z |
| publishDate | 2022-03-01 |
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| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-74e76c7b5a754b7fb240a0f2811486fb2023-11-30T21:29:32ZengMDPI AGMetabolites2218-19892022-03-0112322010.3390/metabo12030220Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic MigraineInge C. M. Loonen0Isabelle Kohler1Mohan Ghorasaini2Martin Giera3Arn M. J. M. van den Maagdenberg4Oleg A. Mayboroda5Else A. Tolner6Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The NetherlandsCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZC Leiden, The NetherlandsCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZC Leiden, The NetherlandsCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZC Leiden, The NetherlandsDepartment of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The NetherlandsCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZC Leiden, The NetherlandsDepartment of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The NetherlandsMetabolite levels in peripheral body fluids can correlate with attack features in migraine patients, which underscores the potential of plasma metabolites as possible disease biomarkers. Migraine headache can be preceded by an aura that is caused by cortical spreading depolarization (CSD), a transient wave of neuroglial depolarization. We previously identified plasma amino acid changes after CSD in familial hemiplegic migraine type 1 (FHM1) mutant mice that exhibit increased neuronal excitability and various migraine-related features. Here, we aimed to uncover lipid metabolic pathways affected by CSD, guided by findings on the involvement of lipids in hemiplegic migraine pathophysiology. Using targeted lipidomic analysis, we studied plasma lipid metabolite levels at different time points after CSD in wild-type and FHM1 mutant mice. Following CSD, the most prominent plasma lipid change concerned a transient increase in PGD<sub>2</sub>, which lasted longer in mutant mice. In wild-type mice only, levels of anti-inflammatory lipid mediators DPAn-3, EPA, ALA, and DHA were elevated 24 h following CSD compared to Sham-treated animals. Given the role of PGs and neuroinflammation in migraine pathophysiology, our findings underscore the potential of monitoring peripheral changes in lipids to gain insight in central brain mechanisms.https://www.mdpi.com/2218-1989/12/3/220cortical spreading depolarizationfamilial hemiplegic migrainemetabolomicslipid mediators |
| spellingShingle | Inge C. M. Loonen Isabelle Kohler Mohan Ghorasaini Martin Giera Arn M. J. M. van den Maagdenberg Oleg A. Mayboroda Else A. Tolner Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine Metabolites cortical spreading depolarization familial hemiplegic migraine metabolomics lipid mediators |
| title | Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine |
| title_full | Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine |
| title_fullStr | Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine |
| title_full_unstemmed | Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine |
| title_short | Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine |
| title_sort | changes in plasma lipid levels following cortical spreading depolarization in a transgenic mouse model of familial hemiplegic migraine |
| topic | cortical spreading depolarization familial hemiplegic migraine metabolomics lipid mediators |
| url | https://www.mdpi.com/2218-1989/12/3/220 |
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