Epigenetic Modifier Supplementation Improves Mitochondrial Respiration and Growth Rates and Alters DNA Methylation of Bovine Embryonic Fibroblast Cells Cultured in Divergent Energy Supply

Epigenetic Modifier Supplementation Improves Mitochondrial Respiration and Growth Rates and Alters DNA Methylation of Bovine Embryonic Fibroblast Cells Cultured in Divergent Energy Supply

Epigenetic modifiers (EM; methionine, choline, folate, and vitamin B12) are important for early embryonic development due to their roles as methyl donors or cofactors in methylation reactions. Additionally, they are essential for the synthesis of nucleotides, polyamines, redox equivalents, and energ...

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Bibliographic Details
Main Authors: Matthew S. Crouse, Joel S. Caton, Kate J. Claycombe-Larson, Wellison J. S. Diniz, Amanda K. Lindholm-Perry, Lawrence P. Reynolds, Carl R. Dahlen, Pawel P. Borowicz, Alison K. Ward
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Genetics
Subjects:
cell growth
DNA methylation
embryonic fibroblasts
mitochondrial respiration
one-carbon metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.812764/full

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