Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival
Objective To investigate the relationship between gender differences in fatty acid-binding protein7 (FABP7) and BRN2 (POU class 3 homeobox 2) expression in renal cell carcinoma (RCC) and the prognosis of patients with RCC. Materials and Methods immunohistochemical (IHC) staining as well as reverse t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-01-01
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| Series: | Clinical Medicine Insights: Oncology |
| Online Access: | https://doi.org/10.4137/CMO.S13684 |
| _version_ | 1818067071879086080 |
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| author | Cheng Tan Tatsuya Takayama Naohisa Takaoka Hiromi Fujita Miki Miyazaki Takayuki Sugiyama Seiichiro Ozono |
| author_facet | Cheng Tan Tatsuya Takayama Naohisa Takaoka Hiromi Fujita Miki Miyazaki Takayuki Sugiyama Seiichiro Ozono |
| author_sort | Cheng Tan |
| collection | DOAJ |
| description | Objective To investigate the relationship between gender differences in fatty acid-binding protein7 (FABP7) and BRN2 (POU class 3 homeobox 2) expression in renal cell carcinoma (RCC) and the prognosis of patients with RCC. Materials and Methods immunohistochemical (IHC) staining as well as reverse transcription-polymerase chain reaction (RT-PCR) was performed in renal tissues from 103 patients (83 men, mean age = 63.6 years old; 20 women, mean age = 63.1 years old) underwent radical nephrectomy from January 1, 2001 through December 31, 2010. The probability of overall patient survival was estimated using the Kaplan–Meier method. Results FABP 7 mRNA expression was more frequent in men ( P = 0.07) while BRN2 protein expression was significantly more frequent in women ( P = 0.029). In particular, FABP7 was expressed in 100% of G1 renal cell carcinoma both in mRNA and protein levels. In women, FABP7 (–) and BRN2 (+) groups had a worse prognosis both in mRNA level ( P = 0.038) and protein level ( P = 0.058). BRN2 was expressed 100% of papillary RCC both in mRNA and protein levels. Conclusions Our results demonstrated that gender was a key factor in FABP7 and BRN2 expression in RCC, and the combination with FABP7 and BRN2 stratified by gender could be a new potential prognostic factor in patients with RCC. |
| first_indexed | 2024-12-10T15:17:51Z |
| format | Article |
| id | doaj.art-74e7f50a0b3c47079d4bb0fe0ba578b6 |
| institution | Directory Open Access Journal |
| issn | 1179-5549 |
| language | English |
| last_indexed | 2024-12-10T15:17:51Z |
| publishDate | 2014-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Oncology |
| spelling | doaj.art-74e7f50a0b3c47079d4bb0fe0ba578b62022-12-22T01:43:45ZengSAGE PublishingClinical Medicine Insights: Oncology1179-55492014-01-01810.4137/CMO.S13684Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall SurvivalCheng Tan0Tatsuya Takayama1Naohisa Takaoka2Hiromi Fujita3Miki Miyazaki4Takayuki Sugiyama5Seiichiro Ozono6Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.Objective To investigate the relationship between gender differences in fatty acid-binding protein7 (FABP7) and BRN2 (POU class 3 homeobox 2) expression in renal cell carcinoma (RCC) and the prognosis of patients with RCC. Materials and Methods immunohistochemical (IHC) staining as well as reverse transcription-polymerase chain reaction (RT-PCR) was performed in renal tissues from 103 patients (83 men, mean age = 63.6 years old; 20 women, mean age = 63.1 years old) underwent radical nephrectomy from January 1, 2001 through December 31, 2010. The probability of overall patient survival was estimated using the Kaplan–Meier method. Results FABP 7 mRNA expression was more frequent in men ( P = 0.07) while BRN2 protein expression was significantly more frequent in women ( P = 0.029). In particular, FABP7 was expressed in 100% of G1 renal cell carcinoma both in mRNA and protein levels. In women, FABP7 (–) and BRN2 (+) groups had a worse prognosis both in mRNA level ( P = 0.038) and protein level ( P = 0.058). BRN2 was expressed 100% of papillary RCC both in mRNA and protein levels. Conclusions Our results demonstrated that gender was a key factor in FABP7 and BRN2 expression in RCC, and the combination with FABP7 and BRN2 stratified by gender could be a new potential prognostic factor in patients with RCC.https://doi.org/10.4137/CMO.S13684 |
| spellingShingle | Cheng Tan Tatsuya Takayama Naohisa Takaoka Hiromi Fujita Miki Miyazaki Takayuki Sugiyama Seiichiro Ozono Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival Clinical Medicine Insights: Oncology |
| title | Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival |
| title_full | Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival |
| title_fullStr | Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival |
| title_full_unstemmed | Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival |
| title_short | Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival |
| title_sort | impact of gender in renal cell carcinoma the relationship of fabp7 and brn2 expression with overall survival |
| url | https://doi.org/10.4137/CMO.S13684 |
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