Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder
ABSTRACT: Background: Bipolar disorder is associated with an increased burden of general medical conditions that might be related to a more severe illness course. Methods: This is a cross-sectional study that evaluated clinical correlates of general medical comorbidities in outpatients with bipolar...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Journal of Affective Disorders Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915320300019 |
| _version_ | 1819278941761830912 |
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| author | Fabiano A. Gomes Pedro V. Magalhães Taylor Magee Elisa Brietzke Maurício Kunz Flávio Kapczinski |
| author_facet | Fabiano A. Gomes Pedro V. Magalhães Taylor Magee Elisa Brietzke Maurício Kunz Flávio Kapczinski |
| author_sort | Fabiano A. Gomes |
| collection | DOAJ |
| description | ABSTRACT: Background: Bipolar disorder is associated with an increased burden of general medical conditions that might be related to a more severe illness course. Methods: This is a cross-sectional study that evaluated clinical correlates of general medical comorbidities in outpatients with bipolar disorder (BD) involving 203 adult patients with a DSM-IV diagnosis of BD, consecutively recruited from the Bipolar Research Program (PROTAHBI) in Porto Alegre, Brazil. Clinical, demographic and anthropometrical variables were systematically assessed, and general medical comorbidity was measured using the Cumulative Illness Rating Scale (CIRS). Results: The prevalence of one or more medical comorbidities was 90.1%. The most common were those from endocrine/metabolic/breast, neurologic and vascular categories. A high burden of general medical comorbidities (defined as CIRS total score ≥ 4) was related to increasing age and body mass index and longer duration of illness after controlling for confounding factors. Limitations: The cross-sectional design limits our ability to make causal conclusions. Also, our sample consisted of patients with longer illness duration from a tertiary clinic and may not generalize to the whole spectrum of bipolar disorder. Conclusions: BD was associated with a high burden of general medical conditions related to age, obesity and longer duration of illness. Medical comorbidities must be incorporated as a core feature in the development of effective treatment strategies for bipolar disorder. |
| first_indexed | 2024-12-24T00:20:01Z |
| format | Article |
| id | doaj.art-74e8756cde7441e5a662452d08ae839f |
| institution | Directory Open Access Journal |
| issn | 2666-9153 |
| language | English |
| last_indexed | 2024-12-24T00:20:01Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj.art-74e8756cde7441e5a662452d08ae839f2022-12-21T17:24:37ZengElsevierJournal of Affective Disorders Reports2666-91532020-12-011100001Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorderFabiano A. Gomes0Pedro V. Magalhães1Taylor Magee2Elisa Brietzke3Maurício Kunz4Flávio Kapczinski5Department of Psychiatry, Queen's University School of Medicine, Kingston, ON, Canada; Kingston Health Sciences Centre, Kingston, ON, Canada; Centre for Neuroscience Studies, Kingston, ON, Canada; Corresponding author: Fabiano Alves Gomes MD, MSc, PhD, 76 Stuart Street, Kingston Health Sciences Centre, Kingston General Hospital Site, Burr 4, Kingston, ON, K7L 2V7, Tel: 613 549 6666 ext. 7887Departmento de Psiquiatria e Medicina Legal, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, BrazilDepartment of Psychiatry, Queen's University School of Medicine, Kingston, ON, Canada; Kingston Health Sciences Centre, Kingston, ON, CanadaDepartment of Psychiatry, Queen's University School of Medicine, Kingston, ON, Canada; Kingston Health Sciences Centre, Kingston, ON, Canada; Centre for Neuroscience Studies, Kingston, ON, CanadaDepartmento de Psiquiatria e Medicina Legal, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, BrazilDepartmento de Psiquiatria e Medicina Legal, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Department of Psychiatry and Behavioral Sciences, McMaster University, Hamilton, ON, CanadaABSTRACT: Background: Bipolar disorder is associated with an increased burden of general medical conditions that might be related to a more severe illness course. Methods: This is a cross-sectional study that evaluated clinical correlates of general medical comorbidities in outpatients with bipolar disorder (BD) involving 203 adult patients with a DSM-IV diagnosis of BD, consecutively recruited from the Bipolar Research Program (PROTAHBI) in Porto Alegre, Brazil. Clinical, demographic and anthropometrical variables were systematically assessed, and general medical comorbidity was measured using the Cumulative Illness Rating Scale (CIRS). Results: The prevalence of one or more medical comorbidities was 90.1%. The most common were those from endocrine/metabolic/breast, neurologic and vascular categories. A high burden of general medical comorbidities (defined as CIRS total score ≥ 4) was related to increasing age and body mass index and longer duration of illness after controlling for confounding factors. Limitations: The cross-sectional design limits our ability to make causal conclusions. Also, our sample consisted of patients with longer illness duration from a tertiary clinic and may not generalize to the whole spectrum of bipolar disorder. Conclusions: BD was associated with a high burden of general medical conditions related to age, obesity and longer duration of illness. Medical comorbidities must be incorporated as a core feature in the development of effective treatment strategies for bipolar disorder.http://www.sciencedirect.com/science/article/pii/S2666915320300019Bipolar disorderGeneral medical comorbidityCirs |
| spellingShingle | Fabiano A. Gomes Pedro V. Magalhães Taylor Magee Elisa Brietzke Maurício Kunz Flávio Kapczinski Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder Journal of Affective Disorders Reports Bipolar disorder General medical comorbidity Cirs |
| title | Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
| title_full | Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
| title_fullStr | Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
| title_full_unstemmed | Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
| title_short | Clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
| title_sort | clinical correlates of high burden of general medical comorbidities in patients with bipolar disorder |
| topic | Bipolar disorder General medical comorbidity Cirs |
| url | http://www.sciencedirect.com/science/article/pii/S2666915320300019 |
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