Association of m1A modification gene polymorphisms with glioma risk in Chinese children
Abstract Glioma is a highly heterogeneous malignancy with a high mortality rate and poor prognosis. m1A methylation modifications are associated with gliomagenesis. However, whether single nucleotide polymorphisms (SNPs) of m1A modification genes are associated with glioma risk is unclear. We succes...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | MedComm – Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mog2.43 |
| _version_ | 1827806043085733888 |
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| author | Fan Liao Rui‐Xi Hua Xingyu Jia Yuxiang Liao Li Yuan Jichen Ruan Tianfeng Li Zhenjian Zhuo Jing He |
| author_facet | Fan Liao Rui‐Xi Hua Xingyu Jia Yuxiang Liao Li Yuan Jichen Ruan Tianfeng Li Zhenjian Zhuo Jing He |
| author_sort | Fan Liao |
| collection | DOAJ |
| description | Abstract Glioma is a highly heterogeneous malignancy with a high mortality rate and poor prognosis. m1A methylation modifications are associated with gliomagenesis. However, whether single nucleotide polymorphisms (SNPs) of m1A modification genes are associated with glioma risk is unclear. We successfully genotyped 20 SNPs of m1A‐modified genes TRMT10C, TRMT61B, TRMT6, TRM61, ALKBH1, YTHDC1, YTHDF1, and YTHDF2 in 314 pediatric glioma patients and 380 cancer‐free controls using TaqMan probes. Associations of polymorphisms with glioma risk were assessed by the odds ratios and 95% confidence intervals generated by logistic regression models. Stratified analysis was performed by age, gender, tumor subtype, and clinical stage. The results showed that TRMT10C rs2303476, TRMT10C rs4257518, TRM61 rs2296484, and YTHDF2 rs3738067 polymorphisms were significantly associated with an increased risk of glioma, TRMT61B rs4563180, YTHDC1 rs2293595, and YTHDC1 rs3813832 polymorphisms were significantly associated with a reduced risk of glioma. In addition, analysis of the expression quantitative trait loci‐showed that the TRM61 rs2296484 T allele significantly increased TRM61 messenger RNA (mRNA) expression, the YTHDF2 rs3738067 G allele significantly increased YTHDF2 mRNA expression, and the TRMT61B rs4563180 C allele significantly decreased TRMT61B mRNA expression. Overall, we identified several promising candidates for m1A modification gene polymorphisms as biomarkers of glioma risk. |
| first_indexed | 2024-03-11T21:34:51Z |
| format | Article |
| id | doaj.art-74ea43560d244ddcbe4858fe598b6de8 |
| institution | Directory Open Access Journal |
| issn | 2769-6448 |
| language | English |
| last_indexed | 2024-03-11T21:34:51Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Oncology |
| spelling | doaj.art-74ea43560d244ddcbe4858fe598b6de82023-09-27T04:32:33ZengWileyMedComm – Oncology2769-64482023-09-0123n/an/a10.1002/mog2.43Association of m1A modification gene polymorphisms with glioma risk in Chinese childrenFan Liao0Rui‐Xi Hua1Xingyu Jia2Yuxiang Liao3Li Yuan4Jichen Ruan5Tianfeng Li6Zhenjian Zhuo7Jing He8School of Medicine South China University of Technology Guangzhou Guangdong ChinaDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics Guangzhou Medical University Guangzhou Guangdong ChinaDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics Guangzhou Medical University Guangzhou Guangdong ChinaDepartment of Neurosurgery, Xiangya Hospital Central South University Changsha Hunan ChinaDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics Guangzhou Medical University Guangzhou Guangdong ChinaDepartment of Hematology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang ChinaReproductive Medicine Center, Affiliated Shenzhen Maternity and Child Healthcare Hospital Southern Medical University Shenzhen Guangdong ChinaDepartment of Pediatric Surgery, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Institute of Pediatrics Guangzhou Medical University Guangzhou Guangdong ChinaSchool of Medicine South China University of Technology Guangzhou Guangdong ChinaAbstract Glioma is a highly heterogeneous malignancy with a high mortality rate and poor prognosis. m1A methylation modifications are associated with gliomagenesis. However, whether single nucleotide polymorphisms (SNPs) of m1A modification genes are associated with glioma risk is unclear. We successfully genotyped 20 SNPs of m1A‐modified genes TRMT10C, TRMT61B, TRMT6, TRM61, ALKBH1, YTHDC1, YTHDF1, and YTHDF2 in 314 pediatric glioma patients and 380 cancer‐free controls using TaqMan probes. Associations of polymorphisms with glioma risk were assessed by the odds ratios and 95% confidence intervals generated by logistic regression models. Stratified analysis was performed by age, gender, tumor subtype, and clinical stage. The results showed that TRMT10C rs2303476, TRMT10C rs4257518, TRM61 rs2296484, and YTHDF2 rs3738067 polymorphisms were significantly associated with an increased risk of glioma, TRMT61B rs4563180, YTHDC1 rs2293595, and YTHDC1 rs3813832 polymorphisms were significantly associated with a reduced risk of glioma. In addition, analysis of the expression quantitative trait loci‐showed that the TRM61 rs2296484 T allele significantly increased TRM61 messenger RNA (mRNA) expression, the YTHDF2 rs3738067 G allele significantly increased YTHDF2 mRNA expression, and the TRMT61B rs4563180 C allele significantly decreased TRMT61B mRNA expression. Overall, we identified several promising candidates for m1A modification gene polymorphisms as biomarkers of glioma risk.https://doi.org/10.1002/mog2.43case‐control studychildrengliomam1ASNP |
| spellingShingle | Fan Liao Rui‐Xi Hua Xingyu Jia Yuxiang Liao Li Yuan Jichen Ruan Tianfeng Li Zhenjian Zhuo Jing He Association of m1A modification gene polymorphisms with glioma risk in Chinese children MedComm – Oncology case‐control study children glioma m1A SNP |
| title | Association of m1A modification gene polymorphisms with glioma risk in Chinese children |
| title_full | Association of m1A modification gene polymorphisms with glioma risk in Chinese children |
| title_fullStr | Association of m1A modification gene polymorphisms with glioma risk in Chinese children |
| title_full_unstemmed | Association of m1A modification gene polymorphisms with glioma risk in Chinese children |
| title_short | Association of m1A modification gene polymorphisms with glioma risk in Chinese children |
| title_sort | association of m1a modification gene polymorphisms with glioma risk in chinese children |
| topic | case‐control study children glioma m1A SNP |
| url | https://doi.org/10.1002/mog2.43 |
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