Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review
IntroductionSpace Motion Sickness (SMS) is a syndrome that affects around 70% of astronauts and includes symptoms of nausea, dizziness, fatigue, vertigo, headaches, vomiting, and cold sweating. Consequences range from discomfort to severe sensorimotor and cognitive incapacitation, which might cause...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neural Circuits |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2023.1150233/full |
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| author | Akil Khalid Pragnya P. Prusty Iqra Arshad Hannah E. Gustafson Isra Jalaly Keith Nockels Barry L. Bentley Rahul Goel Elisa R. Ferrè |
| author_facet | Akil Khalid Pragnya P. Prusty Iqra Arshad Hannah E. Gustafson Isra Jalaly Keith Nockels Barry L. Bentley Rahul Goel Elisa R. Ferrè |
| author_sort | Akil Khalid |
| collection | DOAJ |
| description | IntroductionSpace Motion Sickness (SMS) is a syndrome that affects around 70% of astronauts and includes symptoms of nausea, dizziness, fatigue, vertigo, headaches, vomiting, and cold sweating. Consequences range from discomfort to severe sensorimotor and cognitive incapacitation, which might cause potential problems for mission-critical tasks and astronauts and cosmonauts' well-being. Both pharmacological and non-pharmacological countermeasures have been proposed to mitigate SMS. However, their effectiveness has not been systematically evaluated. Here we present the first systematic review of published peer-reviewed research on the effectiveness of pharmacological and non-pharmacological countermeasures to SMS.MethodsWe performed a double-blind title and abstract screening using the online Rayyan collaboration tool for systematic reviews, followed by a full-text screening. Eventually, only 23 peer-reviewed studies underwent data extraction.ResultsBoth pharmacological and non-pharmacological countermeasures can help mitigate SMS symptoms.DiscussionNo definitive recommendation can be given regarding the superiority of any particular countermeasure approach. Importantly, there is considerable heterogeneity in the published research methods, lack of a standardized assessment approach, and small sample sizes. To allow for consistent comparisons between SMS countermeasures in the future, standardized testing protocols for spaceflight and ground-based analogs are needed. We believe that the data should be made openly available, given the uniqueness of the environment in which it is collected.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021244131. |
| first_indexed | 2024-03-13T05:13:05Z |
| format | Article |
| id | doaj.art-74ed9da621e746b2b144096cd20c50dc |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-03-13T05:13:05Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-74ed9da621e746b2b144096cd20c50dc2023-06-16T04:41:10ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102023-06-011710.3389/fncir.2023.11502331150233Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic reviewAkil Khalid0Pragnya P. Prusty1Iqra Arshad2Hannah E. Gustafson3Isra Jalaly4Keith Nockels5Barry L. Bentley6Rahul Goel7Elisa R. Ferrè8Leicester Medical School, University of Leicester, Leicester, United KingdomDepartment of Audio-Vestibular Sciences, Institute of Health Sciences, Bhubaneswar, IndiaDepartment of Psychology, Royal Holloway University of London, Egham, United KingdomDepartment of Health and Human Performance, University of Houston, Houston, TX, United StatesUniversity College London Medical School, London, United KingdomLibrary and Learning Services, University of Leicester, Leicester, United KingdomCardiff School of Technologies, Cardiff Metropolitan University, Cardiff, United KingdomSan Jose State University-NASA Ames Research Center, Moffett Field, CA, United StatesDepartment of Psychological Sciences, Birkbeck University of London, London, United KingdomIntroductionSpace Motion Sickness (SMS) is a syndrome that affects around 70% of astronauts and includes symptoms of nausea, dizziness, fatigue, vertigo, headaches, vomiting, and cold sweating. Consequences range from discomfort to severe sensorimotor and cognitive incapacitation, which might cause potential problems for mission-critical tasks and astronauts and cosmonauts' well-being. Both pharmacological and non-pharmacological countermeasures have been proposed to mitigate SMS. However, their effectiveness has not been systematically evaluated. Here we present the first systematic review of published peer-reviewed research on the effectiveness of pharmacological and non-pharmacological countermeasures to SMS.MethodsWe performed a double-blind title and abstract screening using the online Rayyan collaboration tool for systematic reviews, followed by a full-text screening. Eventually, only 23 peer-reviewed studies underwent data extraction.ResultsBoth pharmacological and non-pharmacological countermeasures can help mitigate SMS symptoms.DiscussionNo definitive recommendation can be given regarding the superiority of any particular countermeasure approach. Importantly, there is considerable heterogeneity in the published research methods, lack of a standardized assessment approach, and small sample sizes. To allow for consistent comparisons between SMS countermeasures in the future, standardized testing protocols for spaceflight and ground-based analogs are needed. We believe that the data should be made openly available, given the uniqueness of the environment in which it is collected.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021244131.https://www.frontiersin.org/articles/10.3389/fncir.2023.1150233/fullSpace Motion Sickness (SMS)pharmacological countermeasuresnon-pharmacological countermeasureshuman space flightaerospace medicine |
| spellingShingle | Akil Khalid Pragnya P. Prusty Iqra Arshad Hannah E. Gustafson Isra Jalaly Keith Nockels Barry L. Bentley Rahul Goel Elisa R. Ferrè Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review Frontiers in Neural Circuits Space Motion Sickness (SMS) pharmacological countermeasures non-pharmacological countermeasures human space flight aerospace medicine |
| title | Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review |
| title_full | Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review |
| title_fullStr | Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review |
| title_full_unstemmed | Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review |
| title_short | Pharmacological and non-pharmacological countermeasures to Space Motion Sickness: a systematic review |
| title_sort | pharmacological and non pharmacological countermeasures to space motion sickness a systematic review |
| topic | Space Motion Sickness (SMS) pharmacological countermeasures non-pharmacological countermeasures human space flight aerospace medicine |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2023.1150233/full |
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