Spatial Memory Training Counteracts Hippocampal GIRK Channel Decrease in the Transgenic APP<sub>Sw,Ind</sub> J9 Alzheimer’s Disease Mouse Model

Spatial Memory Training Counteracts Hippocampal GIRK Channel Decrease in the Transgenic APP<sub>Sw,Ind</sub> J9 Alzheimer’s Disease Mouse Model

G-protein-gated inwardly rectifying potassium (GIRK) channels are critical determinants of neuronal excitability. They have been proposed as potential targets to restore excitatory/inhibitory balance in acute amyloidosis models, where hyperexcitability is a hallmark. However, the role of GIRK signal...

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Bibliographic Details
Main Authors:	Sara Temprano-Carazo, Ana Contreras, Carlos A. Saura, Juan D. Navarro-López, Lydia Jiménez-Díaz
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Series:	International Journal of Molecular Sciences
Subjects:	hippocampus GIRK Alzheimer’s disease APP<sub>Sw,Ind</sub> J9 spatial memory excitatory/inhibitory imbalance
Online Access:	https://www.mdpi.com/1422-0067/23/21/13444

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