Factors influencing completion of multi-dose vaccine schedules in adolescents: a systematic review
Abstract Background Completion of multiple dose vaccine schedules is crucial to ensure a protective immune response, and maximise vaccine cost-effectiveness. While barriers and facilitators to vaccine uptake have recently been reviewed, there is no comprehensive review of factors influencing subsequ...
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| Format: | Article |
| Language: | English |
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BMC
2016-02-01
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| Series: | BMC Public Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12889-016-2845-z |
| _version_ | 1819059430586580992 |
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| author | K. E. Gallagher E. Kadokura L. O. Eckert S. Miyake S. Mounier-Jack M. Aldea D. A. Ross D. Watson-Jones |
| author_facet | K. E. Gallagher E. Kadokura L. O. Eckert S. Miyake S. Mounier-Jack M. Aldea D. A. Ross D. Watson-Jones |
| author_sort | K. E. Gallagher |
| collection | DOAJ |
| description | Abstract Background Completion of multiple dose vaccine schedules is crucial to ensure a protective immune response, and maximise vaccine cost-effectiveness. While barriers and facilitators to vaccine uptake have recently been reviewed, there is no comprehensive review of factors influencing subsequent adherence or completion, which is key to achieving vaccine effectiveness. This study identifies and summarises the literature on factors affecting completion of multi-dose vaccine schedules by adolescents. Methods Ten online databases and four websites were searched (February 2014). Studies with analysis of factors predicting completion of multi-dose vaccines were included. Study participants within 9–19 years of age were included in the review. The defined outcome was completion of the vaccine series within 1 year among those who received the first dose. Results Overall, 6159 abstracts were screened, and 502 full texts were reviewed. Sixty one studies were eligible for this review. All except two were set in high-income countries. Included studies evaluated human papillomavirus vaccine, hepatitis A, hepatitis B, and varicella vaccines. Reported vaccine completion rates, among those who initiated vaccination, ranged from 27 % to over 90 %. Minority racial or ethnic groups and inadequate health insurance coverage were risk factors for low completion, irrespective of initiation rates. Parental healthcare seeking behaviour was positively associated with completion. Vaccine delivery in schools was associated with higher completion than delivery in the community or health facilities. Gender, prior healthcare use and socio-economic status rarely remained significant risks or protective factors in multivariate analysis. Conclusions Almost all studies investigating factors affecting completion have been carried out in developed countries and investigate a limited range of variables. Increased understanding of barriers to completion in adolescents will be invaluable to future new vaccine introductions and the further development of an adolescent health platform. PROSPERO reg# CRD42014006765. |
| first_indexed | 2024-12-21T14:10:58Z |
| format | Article |
| id | doaj.art-74f116b048094df48ee8555ca6f6d06a |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-21T14:10:58Z |
| publishDate | 2016-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-74f116b048094df48ee8555ca6f6d06a2022-12-21T19:01:03ZengBMCBMC Public Health1471-24582016-02-0116111710.1186/s12889-016-2845-zFactors influencing completion of multi-dose vaccine schedules in adolescents: a systematic reviewK. E. Gallagher0E. Kadokura1L. O. Eckert2S. Miyake3S. Mounier-Jack4M. Aldea5D. A. Ross6D. Watson-Jones7Clinical Research Department, Faculty of Infectious Tropical Diseases, London School of Hygiene and Tropical MedicineDepartment of Epidemiology, University of WashingtonDepartments of Obstetrics and Gynaecology and Global Health, University of WashingtonClinical Research Department, Faculty of Infectious Tropical Diseases, London School of Hygiene and Tropical MedicineDepartment of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical MedicineInfections and Cancer Unit, Cancer Epidemiology Research Programme, Catalan Institute of OncologyMRC Tropical Epidemiology Group, Faculty of Epidemiology and Population Health, London school of Hygiene and Tropical MedicineClinical Research Department, Faculty of Infectious Tropical Diseases, London School of Hygiene and Tropical MedicineAbstract Background Completion of multiple dose vaccine schedules is crucial to ensure a protective immune response, and maximise vaccine cost-effectiveness. While barriers and facilitators to vaccine uptake have recently been reviewed, there is no comprehensive review of factors influencing subsequent adherence or completion, which is key to achieving vaccine effectiveness. This study identifies and summarises the literature on factors affecting completion of multi-dose vaccine schedules by adolescents. Methods Ten online databases and four websites were searched (February 2014). Studies with analysis of factors predicting completion of multi-dose vaccines were included. Study participants within 9–19 years of age were included in the review. The defined outcome was completion of the vaccine series within 1 year among those who received the first dose. Results Overall, 6159 abstracts were screened, and 502 full texts were reviewed. Sixty one studies were eligible for this review. All except two were set in high-income countries. Included studies evaluated human papillomavirus vaccine, hepatitis A, hepatitis B, and varicella vaccines. Reported vaccine completion rates, among those who initiated vaccination, ranged from 27 % to over 90 %. Minority racial or ethnic groups and inadequate health insurance coverage were risk factors for low completion, irrespective of initiation rates. Parental healthcare seeking behaviour was positively associated with completion. Vaccine delivery in schools was associated with higher completion than delivery in the community or health facilities. Gender, prior healthcare use and socio-economic status rarely remained significant risks or protective factors in multivariate analysis. Conclusions Almost all studies investigating factors affecting completion have been carried out in developed countries and investigate a limited range of variables. Increased understanding of barriers to completion in adolescents will be invaluable to future new vaccine introductions and the further development of an adolescent health platform. PROSPERO reg# CRD42014006765.http://link.springer.com/article/10.1186/s12889-016-2845-zVaccines and immunizationImmunization programmesVaccination completionBarriersAdolescent health services |
| spellingShingle | K. E. Gallagher E. Kadokura L. O. Eckert S. Miyake S. Mounier-Jack M. Aldea D. A. Ross D. Watson-Jones Factors influencing completion of multi-dose vaccine schedules in adolescents: a systematic review BMC Public Health Vaccines and immunization Immunization programmes Vaccination completion Barriers Adolescent health services |
| title | Factors influencing completion of multi-dose vaccine schedules in adolescents: a systematic review |
| title_full | Factors influencing completion of multi-dose vaccine schedules in adolescents: a systematic review |
| title_fullStr | Factors influencing completion of multi-dose vaccine schedules in adolescents: a systematic review |
| title_full_unstemmed | Factors influencing completion of multi-dose vaccine schedules in adolescents: a systematic review |
| title_short | Factors influencing completion of multi-dose vaccine schedules in adolescents: a systematic review |
| title_sort | factors influencing completion of multi dose vaccine schedules in adolescents a systematic review |
| topic | Vaccines and immunization Immunization programmes Vaccination completion Barriers Adolescent health services |
| url | http://link.springer.com/article/10.1186/s12889-016-2845-z |
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