Neuroprotective effect of bexarotene in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Neuroprotective effect of bexarotene in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive weakness and muscle atrophy related to the loss of upper and lower motor neurons (MNs) without a curative treatment. There is experimental evidence suggesting that retinoids may be involved in ALS pathoge...

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Autors principals: Javier eRiancho, Maria eRuiz-Soto, Maria T Berciano, José eBerciano, Miguel eLafarga
Format: Article
Idioma:English
Publicat: Frontiers Media S.A. 2015-07-01
Col·lecció:Frontiers in Cellular Neuroscience
Matèries:
Retinoid X Receptors
mouse models
proteostasis
Amyotrophic Lateral Sclerosis (ALS).
Bexarotene
hSOD1G93A
Accés en línia:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00250/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00250/full

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