Cognitive impairment in hospitalized patients with COVID-19
Introduction. The COVD-19 pandemic caused by the SARS-CoV-2 continues from March 2020. The virus primarily affects the respiratory system. Moreover, there is new data about the various organ damage caused by COVID-19 such as heart, skin, kidney and central nervous system. That’s why it is necessary...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2022-03-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/6724 |
| _version_ | 1797841909794734080 |
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| author | S. P. Bordovsky K. D. Tolmachev K. K. Kriukova O. I. Gurina I. S. Preobrazhenskaya |
| author_facet | S. P. Bordovsky K. D. Tolmachev K. K. Kriukova O. I. Gurina I. S. Preobrazhenskaya |
| author_sort | S. P. Bordovsky |
| collection | DOAJ |
| description | Introduction. The COVD-19 pandemic caused by the SARS-CoV-2 continues from March 2020. The virus primarily affects the respiratory system. Moreover, there is new data about the various organ damage caused by COVID-19 such as heart, skin, kidney and central nervous system. That’s why it is necessary to investigate the neurological features of the COVID-19.The aim of the study. To investigate the effect of COVID-19 on the cognitive functions of hospitalized patients.Materials and methods. the PCR-positive patients hospitalized at the University Clinical Hospital No. 3 had been included in the study since March 2020 for May 2021. Thorax CT scan, physical and neurological examination, the biochemical blood test was provided for all patients. The neuropsychological examination was made by: MoCA, TMTA, TMTB, and emotional condition was tested by HADS.Results. 33 patients (21 (64.6%) women) were included; the median age was 73.0 [67.0; 76.0]. The average MoCA value was 22.64 points, median: 24.00 points [20.00; 25.00], median TMTA execution speed: 68 seconds [49.00; 84.00], TMTB: 194 seconds [153; 245.75]. HADS (depression) median: 7.0 [5.00; 9.00], for HADS (anxiety) median: 8.0 [4.00; 10.00]. A link between the olfactory disorders and low MoCA results (p = 0.015) was found according to the regression analysis. Moreover, the patient’s age, lung damage degree had a negative impact on the duration of TMTB (p = 0.001 and p = 0.049). The propensity score matching was made to confirm that the olfactory disturbances, regardless of other factors, are associated with a lower MoCA result (p = 0.012).Conclusion. The potential mechanisms, modality, defect duration and pharmacological response of cognitive disorders have a great interest. That’s why it is necessary to conduct clinical and experimental studies on patients, pathomorphological material and animal models. |
| first_indexed | 2024-04-09T16:39:04Z |
| format | Article |
| id | doaj.art-74f15e6ef7654fa6a972ab5a72edb690 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:39:04Z |
| publishDate | 2022-03-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-74f15e6ef7654fa6a972ab5a72edb6902023-04-23T06:56:45ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902022-03-0102243210.21518/2079-701X-2022-16-2-24-326046Cognitive impairment in hospitalized patients with COVID-19S. P. Bordovsky0K. D. Tolmachev1K. K. Kriukova2O. I. Gurina3I. S. Preobrazhenskaya4Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University)Institute of Vocational Education, Sechenov First Moscow State Medical University (Sechenov University)Sklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University)Serbskiy National Medical Research Center for Psychiatry and NarcologySklifosovsky Institute of Clinical Medicine, Sechenov First Moscow State Medical University (Sechenov University)Introduction. The COVD-19 pandemic caused by the SARS-CoV-2 continues from March 2020. The virus primarily affects the respiratory system. Moreover, there is new data about the various organ damage caused by COVID-19 such as heart, skin, kidney and central nervous system. That’s why it is necessary to investigate the neurological features of the COVID-19.The aim of the study. To investigate the effect of COVID-19 on the cognitive functions of hospitalized patients.Materials and methods. the PCR-positive patients hospitalized at the University Clinical Hospital No. 3 had been included in the study since March 2020 for May 2021. Thorax CT scan, physical and neurological examination, the biochemical blood test was provided for all patients. The neuropsychological examination was made by: MoCA, TMTA, TMTB, and emotional condition was tested by HADS.Results. 33 patients (21 (64.6%) women) were included; the median age was 73.0 [67.0; 76.0]. The average MoCA value was 22.64 points, median: 24.00 points [20.00; 25.00], median TMTA execution speed: 68 seconds [49.00; 84.00], TMTB: 194 seconds [153; 245.75]. HADS (depression) median: 7.0 [5.00; 9.00], for HADS (anxiety) median: 8.0 [4.00; 10.00]. A link between the olfactory disorders and low MoCA results (p = 0.015) was found according to the regression analysis. Moreover, the patient’s age, lung damage degree had a negative impact on the duration of TMTB (p = 0.001 and p = 0.049). The propensity score matching was made to confirm that the olfactory disturbances, regardless of other factors, are associated with a lower MoCA result (p = 0.012).Conclusion. The potential mechanisms, modality, defect duration and pharmacological response of cognitive disorders have a great interest. That’s why it is necessary to conduct clinical and experimental studies on patients, pathomorphological material and animal models.https://www.med-sovet.pro/jour/article/view/6724sars-cov-2elderly patientsanosmiahyposmiaalzheimer’s diseasememantinenmda-antagonists |
| spellingShingle | S. P. Bordovsky K. D. Tolmachev K. K. Kriukova O. I. Gurina I. S. Preobrazhenskaya Cognitive impairment in hospitalized patients with COVID-19 Медицинский совет sars-cov-2 elderly patients anosmia hyposmia alzheimer’s disease memantine nmda-antagonists |
| title | Cognitive impairment in hospitalized patients with COVID-19 |
| title_full | Cognitive impairment in hospitalized patients with COVID-19 |
| title_fullStr | Cognitive impairment in hospitalized patients with COVID-19 |
| title_full_unstemmed | Cognitive impairment in hospitalized patients with COVID-19 |
| title_short | Cognitive impairment in hospitalized patients with COVID-19 |
| title_sort | cognitive impairment in hospitalized patients with covid 19 |
| topic | sars-cov-2 elderly patients anosmia hyposmia alzheimer’s disease memantine nmda-antagonists |
| url | https://www.med-sovet.pro/jour/article/view/6724 |
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