Comparing efficacy of oral clonidine and gabapentin premedication for post-operative pain and analgesic requirement in patient undergoing laparoscopic cholecystectomy: A prospective, double-blind, and placebo-controlled study
Background: Post-operative pain is an area, which has been receiving an increasing amount of attention in recent years. Pain associated with laparoscopic cholecystectomy has been an area of interest for many, various modalities have been tried for pain relief. Aims and Objectives: The study aimed...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-10-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/45697 |
| _version_ | 1818029372622241792 |
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| author | Ravi Prakash Amey Dixit Kuldeep Kumar Patel Ashish Malik |
| author_facet | Ravi Prakash Amey Dixit Kuldeep Kumar Patel Ashish Malik |
| author_sort | Ravi Prakash |
| collection | DOAJ |
| description | Background: Post-operative pain is an area, which has been receiving an increasing amount of attention in recent years. Pain associated with laparoscopic cholecystectomy has been an area of interest for many, various modalities have been tried for pain relief.
Aims and Objectives: The study aimed at comparing analgesic efficacy of oral clonidine and gabapentin premedication on post-operative pain and analgesic requirement in patients undergoing laparoscopic cholecystectomy.
Materials and Methods: Ninety patients of American Society of Anesthesiologists Status I and II, between 20 and 60 years undergoing elective laparoscopic cholecystectomy, were randomized into three groups. Group C received 150 mcg of clonidine, Group G received 600 mg of gabapentin, and Group P received placebo multivitamin tablets 2 h before surgery. The primary objective was to study the duration of post-operative analgesia and total rescue analgesic required. The secondary objective was to find out any sedation and adverse effect associated with the use of premedicant drugs.
Results: The duration of analgesia was found to be highest in Group G (174.33±85.81 min) than in Group C (77.17±63.99 min) and Group P (29.33±14.55 min). Total dose of tramadol consumption in 6 h was highest in Group P (91.67±23.06 mg) with statistically insignificant difference between Group G (46.67±12.69 mg) and Group C (48.33±9.13 mg). No statistically significant adverse event was noted in post-operative period.
Conclusion: The use of oral clonidine and gabapentin 2 h before laparoscopic cholecystectomy significantly prolongs duration of post-operative analgesia and decreases the requirement of rescue analgesics without causing any significant adverse events. |
| first_indexed | 2024-12-10T05:18:39Z |
| format | Article |
| id | doaj.art-74f4a73b262c456fbf8ca4dbb7e2d5c4 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-10T05:18:39Z |
| publishDate | 2022-10-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-74f4a73b262c456fbf8ca4dbb7e2d5c42022-12-22T02:00:52ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-10-0113103541https://doi.org/10.3126/ajms.v13i10.45697Comparing efficacy of oral clonidine and gabapentin premedication for post-operative pain and analgesic requirement in patient undergoing laparoscopic cholecystectomy: A prospective, double-blind, and placebo-controlled studyRavi Prakash 0https://orcid.org/0000-0001-6332-9530Amey Dixit 1https://orcid.org/0000-0001-7627-0048Kuldeep Kumar Patel 2https://orcid.org/0000-0002-9506-6090Ashish Malik 3https://orcid.org/0000-0003-3474-2873Assistant Professor, Department of Anaesthesiology, Superspeciality Block, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Senior Resident, Department of Anaesthesiology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Assistant Professor, Department of Anaesthesiology, Shyam Shah Medical College, Rewa, Madhya Pradesh, India Senior Consultant, Department of Anaesthesiology, Indraprastha Apollo Hospital, Sarita Vihar, New Delhi, India Background: Post-operative pain is an area, which has been receiving an increasing amount of attention in recent years. Pain associated with laparoscopic cholecystectomy has been an area of interest for many, various modalities have been tried for pain relief. Aims and Objectives: The study aimed at comparing analgesic efficacy of oral clonidine and gabapentin premedication on post-operative pain and analgesic requirement in patients undergoing laparoscopic cholecystectomy. Materials and Methods: Ninety patients of American Society of Anesthesiologists Status I and II, between 20 and 60 years undergoing elective laparoscopic cholecystectomy, were randomized into three groups. Group C received 150 mcg of clonidine, Group G received 600 mg of gabapentin, and Group P received placebo multivitamin tablets 2 h before surgery. The primary objective was to study the duration of post-operative analgesia and total rescue analgesic required. The secondary objective was to find out any sedation and adverse effect associated with the use of premedicant drugs. Results: The duration of analgesia was found to be highest in Group G (174.33±85.81 min) than in Group C (77.17±63.99 min) and Group P (29.33±14.55 min). Total dose of tramadol consumption in 6 h was highest in Group P (91.67±23.06 mg) with statistically insignificant difference between Group G (46.67±12.69 mg) and Group C (48.33±9.13 mg). No statistically significant adverse event was noted in post-operative period. Conclusion: The use of oral clonidine and gabapentin 2 h before laparoscopic cholecystectomy significantly prolongs duration of post-operative analgesia and decreases the requirement of rescue analgesics without causing any significant adverse events.https://www.nepjol.info/index.php/AJMS/article/view/45697clonidinegabapentinlaparoscopic cholecystectomypost-operative painpremedication |
| spellingShingle | Ravi Prakash Amey Dixit Kuldeep Kumar Patel Ashish Malik Comparing efficacy of oral clonidine and gabapentin premedication for post-operative pain and analgesic requirement in patient undergoing laparoscopic cholecystectomy: A prospective, double-blind, and placebo-controlled study Asian Journal of Medical Sciences clonidine gabapentin laparoscopic cholecystectomy post-operative pain premedication |
| title | Comparing efficacy of oral clonidine and gabapentin premedication for post-operative pain and analgesic requirement in patient undergoing laparoscopic cholecystectomy: A prospective, double-blind, and placebo-controlled study |
| title_full | Comparing efficacy of oral clonidine and gabapentin premedication for post-operative pain and analgesic requirement in patient undergoing laparoscopic cholecystectomy: A prospective, double-blind, and placebo-controlled study |
| title_fullStr | Comparing efficacy of oral clonidine and gabapentin premedication for post-operative pain and analgesic requirement in patient undergoing laparoscopic cholecystectomy: A prospective, double-blind, and placebo-controlled study |
| title_full_unstemmed | Comparing efficacy of oral clonidine and gabapentin premedication for post-operative pain and analgesic requirement in patient undergoing laparoscopic cholecystectomy: A prospective, double-blind, and placebo-controlled study |
| title_short | Comparing efficacy of oral clonidine and gabapentin premedication for post-operative pain and analgesic requirement in patient undergoing laparoscopic cholecystectomy: A prospective, double-blind, and placebo-controlled study |
| title_sort | comparing efficacy of oral clonidine and gabapentin premedication for post operative pain and analgesic requirement in patient undergoing laparoscopic cholecystectomy a prospective double blind and placebo controlled study |
| topic | clonidine gabapentin laparoscopic cholecystectomy post-operative pain premedication |
| url | https://www.nepjol.info/index.php/AJMS/article/view/45697 |
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