CRISPR/Cas9 system in breast cancer therapy: advancement, limitations and future scope
Abstract Cancer is one of the major causes of mortality worldwide, therefore it is considered a major health concern. Breast cancer is the most frequent type of cancer which affects women on a global scale. Various current treatment strategies have been implicated for breast cancer therapy that incl...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02654-3 |
| _version_ | 1818015072649216000 |
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| author | Vamika Karn Sandhya Sandhya Wayne Hsu Deepak Parashar Himanshu Narayan Singh Niraj Kumar Jha Saurabh Gupta Navneet Kumar Dubey Sanjay Kumar |
| author_facet | Vamika Karn Sandhya Sandhya Wayne Hsu Deepak Parashar Himanshu Narayan Singh Niraj Kumar Jha Saurabh Gupta Navneet Kumar Dubey Sanjay Kumar |
| author_sort | Vamika Karn |
| collection | DOAJ |
| description | Abstract Cancer is one of the major causes of mortality worldwide, therefore it is considered a major health concern. Breast cancer is the most frequent type of cancer which affects women on a global scale. Various current treatment strategies have been implicated for breast cancer therapy that includes surgical removal, radiation therapy, hormonal therapy, chemotherapy, and targeted biological therapy. However, constant effort is being made to introduce novel therapies with minimal toxicity. Gene therapy is one of the promising tools, to rectify defective genes and cure various cancers. In recent years, a novel genome engineering technology, namely the clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein-9 (Cas9) has emerged as a gene-editing tool and transformed genome-editing techniques in a wide range of biological domains including human cancer research and gene therapy. This could be attributed to its versatile characteristics such as high specificity, precision, time-saving and cost-effective methodologies with minimal risk. In the present review, we highlight the role of CRISPR/Cas9 as a targeted therapy to tackle drug resistance, improve immunotherapy for breast cancer. |
| first_indexed | 2024-04-14T06:53:24Z |
| format | Article |
| id | doaj.art-74f50111a16545f18ddc2b4719976c93 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-14T06:53:24Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-74f50111a16545f18ddc2b4719976c932022-12-22T02:06:58ZengBMCCancer Cell International1475-28672022-07-0122111410.1186/s12935-022-02654-3CRISPR/Cas9 system in breast cancer therapy: advancement, limitations and future scopeVamika Karn0Sandhya Sandhya1Wayne Hsu2Deepak Parashar3Himanshu Narayan Singh4Niraj Kumar Jha5Saurabh Gupta6Navneet Kumar Dubey7Sanjay Kumar8Department of Biotechnology, Amity UniversityDivision of Oncology Research, Mayo ClinicDivision of General Surgery, Department of Surgery, Taipei Medical University HospitalDepartment of Obstetrics and Gynaecology, Medical College of WisconsinDepartment of System Biology, Columbia University Irving Medical CentreDepartment of Biotechnology, School of Engineering & Technology (SET), Sharda UniversityDepartment of Biotechnology, GLA UniversityVictory Biotechnology Co., Ltd.Department of Life Sciences, School of Basic Sciences and Research, Sharda UniversityAbstract Cancer is one of the major causes of mortality worldwide, therefore it is considered a major health concern. Breast cancer is the most frequent type of cancer which affects women on a global scale. Various current treatment strategies have been implicated for breast cancer therapy that includes surgical removal, radiation therapy, hormonal therapy, chemotherapy, and targeted biological therapy. However, constant effort is being made to introduce novel therapies with minimal toxicity. Gene therapy is one of the promising tools, to rectify defective genes and cure various cancers. In recent years, a novel genome engineering technology, namely the clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein-9 (Cas9) has emerged as a gene-editing tool and transformed genome-editing techniques in a wide range of biological domains including human cancer research and gene therapy. This could be attributed to its versatile characteristics such as high specificity, precision, time-saving and cost-effective methodologies with minimal risk. In the present review, we highlight the role of CRISPR/Cas9 as a targeted therapy to tackle drug resistance, improve immunotherapy for breast cancer.https://doi.org/10.1186/s12935-022-02654-3CRISPR/Cas9Breast cancerGene editingImmunotherapyDiagnosisDrug resistance |
| spellingShingle | Vamika Karn Sandhya Sandhya Wayne Hsu Deepak Parashar Himanshu Narayan Singh Niraj Kumar Jha Saurabh Gupta Navneet Kumar Dubey Sanjay Kumar CRISPR/Cas9 system in breast cancer therapy: advancement, limitations and future scope Cancer Cell International CRISPR/Cas9 Breast cancer Gene editing Immunotherapy Diagnosis Drug resistance |
| title | CRISPR/Cas9 system in breast cancer therapy: advancement, limitations and future scope |
| title_full | CRISPR/Cas9 system in breast cancer therapy: advancement, limitations and future scope |
| title_fullStr | CRISPR/Cas9 system in breast cancer therapy: advancement, limitations and future scope |
| title_full_unstemmed | CRISPR/Cas9 system in breast cancer therapy: advancement, limitations and future scope |
| title_short | CRISPR/Cas9 system in breast cancer therapy: advancement, limitations and future scope |
| title_sort | crispr cas9 system in breast cancer therapy advancement limitations and future scope |
| topic | CRISPR/Cas9 Breast cancer Gene editing Immunotherapy Diagnosis Drug resistance |
| url | https://doi.org/10.1186/s12935-022-02654-3 |
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