MSC-derived exosomes attenuate hepatic fibrosis in primary sclerosing cholangitis through inhibition of Th17 differentiation

MSC-derived exosomes attenuate hepatic fibrosis in primary sclerosing cholangitis through inhibition of Th17 differentiation

Primary sclerosing cholangitis (PSC) is an autoimmune cholangiopathy characterized by chronic inflammation of the biliary epithelium and periductal fibrosis, with no curative treatment available, and liver transplantation is inevitable for end-stage patients. Human placental mesenchymal stem cell (h...

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Bibliographic Details
Main Authors: Wenyi Chen, Feiyan Lin, Xudong Feng, Qigu Yao, Yingduo Yu, Feiqiong Gao, Jiahang Zhou, Qiaoling Pan, Jian Wu, Jinfeng Yang, Jiong Yu, Hongcui Cao, Lanjuan Li
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Mesenchymal stem cell
Exosomes
Primary sclerosing cholangitis
Fibrosis
Organoids
Th17
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087624000060

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