Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition

Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition

Hepatic metastatic growth is dependent upon stromal factors including the matrisomal proteins that make up the extracellular matrix (ECM). Laminins are ECM glycoproteins with several functions relevant to tumour progression including angiogenesis. We investigated whether metastatic colon cancer cell...

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Bibliographic Details
Main Authors: Alex Gordon-Weeks, Su Yin Lim, Arseniy Yuzhalin, Serena Lucotti, Jenny Adriana Francisca Vermeer, Keaton Jones, Jianzhou Chen, Ruth J. Muschel
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
liver metastasis
laminin
angiogenesis
Notch
microenvironment
matrisome
Online Access:https://www.mdpi.com/2072-6694/11/5/630

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