Modeling the Impact of Exogenous Boosting and Universal Varicella Vaccination on the Clinical and Economic Burden of Varicella and Herpes Zoster in a Dynamic Population for England and Wales
Universal varicella vaccination (UVV) in England and Wales has been hindered by its potential impact on exogenous boosting and increase in herpes zoster (HZ) incidence. We projected the impact of ten UVV strategies in England and Wales on the incidence of varicella and HZ and evaluated their cost-ef...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/9/1416 |
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| author | Oluwaseun Sharomi Ilaria Xausa Robert Nachbar Matthew Pillsbury Ian Matthews Tanaz Petigara Elamin Elbasha Manjiri Pawaskar |
| author_facet | Oluwaseun Sharomi Ilaria Xausa Robert Nachbar Matthew Pillsbury Ian Matthews Tanaz Petigara Elamin Elbasha Manjiri Pawaskar |
| author_sort | Oluwaseun Sharomi |
| collection | DOAJ |
| description | Universal varicella vaccination (UVV) in England and Wales has been hindered by its potential impact on exogenous boosting and increase in herpes zoster (HZ) incidence. We projected the impact of ten UVV strategies in England and Wales on the incidence of varicella and HZ and evaluated their cost-effectiveness over 50 years. The Maternal-Susceptible-Exposed-Infected-Recovered-Vaccinated transmission model was extended in a dynamically changing, age-structured population. Our model estimated that one- or two-dose UVV strategies significantly reduced varicella incidence (70–92%), hospitalizations (70–90%), and mortality (16–41%) over 50 years. A small rise in HZ cases was projected with UVV, peaking 22 years after introduction at 5.3–7.1% above pre-UVV rates. Subsequently, HZ incidence steadily decreased, falling 12.2–14.1% below pre-UVV rates after 50 years. At a willingness-to-pay threshold of 20,000 GBP/QALY, each UVV strategy was cost-effective versus no UVV. Frontier analysis showed that one-dose UVV with MMRV-MSD administered at 18 months is the only cost-effective strategy compared to other strategies. HZ incidence varied under alternative exogenous boosting assumptions, but most UVV strategies remained cost-effective. HZ vaccination decreased HZ incidence with minimal impact on the cost-effectiveness. Introducing a UVV program would significantly reduce the clinical burden of varicella and be cost-effective versus no UVV after accounting for the impact on HZ incidence. |
| first_indexed | 2024-03-09T22:17:18Z |
| format | Article |
| id | doaj.art-74f7ac77012640eba56d0493e1c8a1d2 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:17:18Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-74f7ac77012640eba56d0493e1c8a1d22023-11-23T19:20:42ZengMDPI AGVaccines2076-393X2022-08-01109141610.3390/vaccines10091416Modeling the Impact of Exogenous Boosting and Universal Varicella Vaccination on the Clinical and Economic Burden of Varicella and Herpes Zoster in a Dynamic Population for England and WalesOluwaseun Sharomi0Ilaria Xausa1Robert Nachbar2Matthew Pillsbury3Ian Matthews4Tanaz Petigara5Elamin Elbasha6Manjiri Pawaskar7Merck & Co., Inc., 126 E Lincoln Ave, Rahway, NJ 07065, USAWolfram Research Inc., 100 Trade Center Drive, Champaign, IL 61820, USAWolfram Research Inc., 100 Trade Center Drive, Champaign, IL 61820, USAIndependent Researcher, Rahway, NJ 07065, USAMerck Sharpe and Dome (UK) Ltd., 120 Moorgate, London EC2M 6UR, UKMerck & Co., Inc., 126 E Lincoln Ave, Rahway, NJ 07065, USAMerck & Co., Inc., 126 E Lincoln Ave, Rahway, NJ 07065, USAMerck & Co., Inc., 126 E Lincoln Ave, Rahway, NJ 07065, USAUniversal varicella vaccination (UVV) in England and Wales has been hindered by its potential impact on exogenous boosting and increase in herpes zoster (HZ) incidence. We projected the impact of ten UVV strategies in England and Wales on the incidence of varicella and HZ and evaluated their cost-effectiveness over 50 years. The Maternal-Susceptible-Exposed-Infected-Recovered-Vaccinated transmission model was extended in a dynamically changing, age-structured population. Our model estimated that one- or two-dose UVV strategies significantly reduced varicella incidence (70–92%), hospitalizations (70–90%), and mortality (16–41%) over 50 years. A small rise in HZ cases was projected with UVV, peaking 22 years after introduction at 5.3–7.1% above pre-UVV rates. Subsequently, HZ incidence steadily decreased, falling 12.2–14.1% below pre-UVV rates after 50 years. At a willingness-to-pay threshold of 20,000 GBP/QALY, each UVV strategy was cost-effective versus no UVV. Frontier analysis showed that one-dose UVV with MMRV-MSD administered at 18 months is the only cost-effective strategy compared to other strategies. HZ incidence varied under alternative exogenous boosting assumptions, but most UVV strategies remained cost-effective. HZ vaccination decreased HZ incidence with minimal impact on the cost-effectiveness. Introducing a UVV program would significantly reduce the clinical burden of varicella and be cost-effective versus no UVV after accounting for the impact on HZ incidence.https://www.mdpi.com/2076-393X/10/9/1416varicellaherpes zostervaccinationcost-effectivenessdynamic modeling |
| spellingShingle | Oluwaseun Sharomi Ilaria Xausa Robert Nachbar Matthew Pillsbury Ian Matthews Tanaz Petigara Elamin Elbasha Manjiri Pawaskar Modeling the Impact of Exogenous Boosting and Universal Varicella Vaccination on the Clinical and Economic Burden of Varicella and Herpes Zoster in a Dynamic Population for England and Wales Vaccines varicella herpes zoster vaccination cost-effectiveness dynamic modeling |
| title | Modeling the Impact of Exogenous Boosting and Universal Varicella Vaccination on the Clinical and Economic Burden of Varicella and Herpes Zoster in a Dynamic Population for England and Wales |
| title_full | Modeling the Impact of Exogenous Boosting and Universal Varicella Vaccination on the Clinical and Economic Burden of Varicella and Herpes Zoster in a Dynamic Population for England and Wales |
| title_fullStr | Modeling the Impact of Exogenous Boosting and Universal Varicella Vaccination on the Clinical and Economic Burden of Varicella and Herpes Zoster in a Dynamic Population for England and Wales |
| title_full_unstemmed | Modeling the Impact of Exogenous Boosting and Universal Varicella Vaccination on the Clinical and Economic Burden of Varicella and Herpes Zoster in a Dynamic Population for England and Wales |
| title_short | Modeling the Impact of Exogenous Boosting and Universal Varicella Vaccination on the Clinical and Economic Burden of Varicella and Herpes Zoster in a Dynamic Population for England and Wales |
| title_sort | modeling the impact of exogenous boosting and universal varicella vaccination on the clinical and economic burden of varicella and herpes zoster in a dynamic population for england and wales |
| topic | varicella herpes zoster vaccination cost-effectiveness dynamic modeling |
| url | https://www.mdpi.com/2076-393X/10/9/1416 |
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