Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression
Background: Insecure attachment style (anxious and avoidant) predisposes to the development of depression and has been linked to hippocampal alterations in healthy individuals. However, it is unclear if there are alterations of the hippocampus and the parahippocampal cingulum (PHC) in patients with...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Journal of Affective Disorders Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915322001275 |
| _version_ | 1828123417963921408 |
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| author | Tobias Bracht Niklaus Denier Meret Wallimann Sebastian Walther Nicolas Mertse Sigrid Breit Andrea Federspiel Roland Wiest Leila Soravia |
| author_facet | Tobias Bracht Niklaus Denier Meret Wallimann Sebastian Walther Nicolas Mertse Sigrid Breit Andrea Federspiel Roland Wiest Leila Soravia |
| author_sort | Tobias Bracht |
| collection | DOAJ |
| description | Background: Insecure attachment style (anxious and avoidant) predisposes to the development of depression and has been linked to hippocampal alterations in healthy individuals. However, it is unclear if there are alterations of the hippocampus and the parahippocampal cingulum (PHC) in patients with depression. Methods: Forty-eight patients with major depressive disorder and 18 healthy controls underwent MP2RAGE and diffusion-weighted magnetic resonance imaging. Attachment characteristics were assessed with the revised adult attachment scale. Patients were classified into subgroups with low (anxious: n = 27; avoidant: n = 21) and high (anxious: n = 20; avoidant: n = 28) attachment characteristics. Bilateral PHC were reconstructed using manual tractography. Hippocampal volumes, mean fractional anisotropy and mean diffusivity (MD) in bilateral PHC were compared between attachment subgroups and healthy controls. Results: Patients had higher scores of anxious and avoidant attachment, which were associated with depression severity. Patients with high avoidance had decreases in hippocampal volumes in comparison to patients with low avoidance. Furthermore, patients with high avoidance had increased MD in bilateral PHC in comparison to patients with low avoidance and in comparison to healthy controls. Limitations: Assessment of attachment characteristics may be influenced by cognitive biases due to depressive symptoms Conclusions: High attachment avoidance in patients with depression is associated with volume reductions in the hippocampus and impaired PHC-microstructure. |
| first_indexed | 2024-04-11T14:51:45Z |
| format | Article |
| id | doaj.art-74f83660628843369e4d12e931b4c06a |
| institution | Directory Open Access Journal |
| issn | 2666-9153 |
| language | English |
| last_indexed | 2024-04-11T14:51:45Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj.art-74f83660628843369e4d12e931b4c06a2022-12-22T04:17:25ZengElsevierJournal of Affective Disorders Reports2666-91532022-12-0110100435Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depressionTobias Bracht0Niklaus Denier1Meret Wallimann2Sebastian Walther3Nicolas Mertse4Sigrid Breit5Andrea Federspiel6Roland Wiest7Leila Soravia8Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland; Corresponding author at: University Hospital of Psychiatry and Psychotherapy, University of Bern, Translational Research Center, Bolligenstrasse 111, 3000 Bern 60, Switzerland.Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandTranslational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland; Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, SwitzerlandTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, SwitzerlandBackground: Insecure attachment style (anxious and avoidant) predisposes to the development of depression and has been linked to hippocampal alterations in healthy individuals. However, it is unclear if there are alterations of the hippocampus and the parahippocampal cingulum (PHC) in patients with depression. Methods: Forty-eight patients with major depressive disorder and 18 healthy controls underwent MP2RAGE and diffusion-weighted magnetic resonance imaging. Attachment characteristics were assessed with the revised adult attachment scale. Patients were classified into subgroups with low (anxious: n = 27; avoidant: n = 21) and high (anxious: n = 20; avoidant: n = 28) attachment characteristics. Bilateral PHC were reconstructed using manual tractography. Hippocampal volumes, mean fractional anisotropy and mean diffusivity (MD) in bilateral PHC were compared between attachment subgroups and healthy controls. Results: Patients had higher scores of anxious and avoidant attachment, which were associated with depression severity. Patients with high avoidance had decreases in hippocampal volumes in comparison to patients with low avoidance. Furthermore, patients with high avoidance had increased MD in bilateral PHC in comparison to patients with low avoidance and in comparison to healthy controls. Limitations: Assessment of attachment characteristics may be influenced by cognitive biases due to depressive symptoms Conclusions: High attachment avoidance in patients with depression is associated with volume reductions in the hippocampus and impaired PHC-microstructure.http://www.sciencedirect.com/science/article/pii/S2666915322001275DepressionAttachmentHippocampus, CingulumWhite matterDiffusion tensor imaging |
| spellingShingle | Tobias Bracht Niklaus Denier Meret Wallimann Sebastian Walther Nicolas Mertse Sigrid Breit Andrea Federspiel Roland Wiest Leila Soravia Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression Journal of Affective Disorders Reports Depression Attachment Hippocampus, Cingulum White matter Diffusion tensor imaging |
| title | Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression |
| title_full | Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression |
| title_fullStr | Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression |
| title_full_unstemmed | Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression |
| title_short | Hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression |
| title_sort | hippocampal volume and parahippocampal cingulum alterations are associated with avoidant attachment in patients with depression |
| topic | Depression Attachment Hippocampus, Cingulum White matter Diffusion tensor imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2666915322001275 |
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