Crocetin: A Systematic Review
Crocetin is an aglycone of crocin naturally occurring in saffron and produced in biological systems by hydrolysis of crocin as a bioactive metabolite. It is known to exist in several medicinal plants, the desiccative ripe fruit of the cape jasmine belonging to the Rubiaceae family, and stigmas of th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.745683/full |
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| author | Zi-Liang Guo Zi-Liang Guo Mao-Xing Li Mao-Xing Li Mao-Xing Li Xiao-Lin Li Peng Wang Peng Wang Wei-Gang Wang Wei-Gang Wang Wei-Ze Du Wei-Ze Du Zhi-Qiang Yang Zhi-Qiang Yang Sheng-Fu Chen Sheng-Fu Chen Di Wu Di Wu Xiu-Yu Tian Xiu-Yu Tian |
| author_facet | Zi-Liang Guo Zi-Liang Guo Mao-Xing Li Mao-Xing Li Mao-Xing Li Xiao-Lin Li Peng Wang Peng Wang Wei-Gang Wang Wei-Gang Wang Wei-Ze Du Wei-Ze Du Zhi-Qiang Yang Zhi-Qiang Yang Sheng-Fu Chen Sheng-Fu Chen Di Wu Di Wu Xiu-Yu Tian Xiu-Yu Tian |
| author_sort | Zi-Liang Guo |
| collection | DOAJ |
| description | Crocetin is an aglycone of crocin naturally occurring in saffron and produced in biological systems by hydrolysis of crocin as a bioactive metabolite. It is known to exist in several medicinal plants, the desiccative ripe fruit of the cape jasmine belonging to the Rubiaceae family, and stigmas of the saffron plant of the Iridaceae family. According to modern pharmacological investigations, crocetin possesses cardioprotective, hepatoprotective, neuroprotective, antidepressant, antiviral, anticancer, atherosclerotic, antidiabetic, and memory-enhancing properties. Although poor bioavailability hinders therapeutic applications, derivatization and formulation preparation technologies have broadened the application prospects for crocetin. To promote the research and development of crocetin, we summarized the distribution, preparation and production, total synthesis and derivatization technology, pharmacological activity, pharmacokinetics, drug safety, drug formulations, and preparation of crocetin. |
| first_indexed | 2024-04-11T17:10:28Z |
| format | Article |
| id | doaj.art-74f8d37837e04fa7af064f1b470b8f99 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T17:10:28Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-74f8d37837e04fa7af064f1b470b8f992022-12-22T04:12:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-01-011210.3389/fphar.2021.745683745683Crocetin: A Systematic ReviewZi-Liang Guo0Zi-Liang Guo1Mao-Xing Li2Mao-Xing Li3Mao-Xing Li4Xiao-Lin Li5Peng Wang6Peng Wang7Wei-Gang Wang8Wei-Gang Wang9Wei-Ze Du10Wei-Ze Du11Zhi-Qiang Yang12Zhi-Qiang Yang13Sheng-Fu Chen14Sheng-Fu Chen15Di Wu16Di Wu17Xiu-Yu Tian18Xiu-Yu Tian19Department of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, ChinaCollege of Pharmacy, Lanzhou University, Lanzhou, ChinaDepartment of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, ChinaCollege of Pharmacy, Lanzhou University, Lanzhou, ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, ChinaDepartment of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, ChinaDepartment of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, ChinaDepartment of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, ChinaDepartment of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, ChinaDepartment of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, ChinaInstitute of Chemical Technology, Northwest Minzu University, Lanzhou, ChinaDepartment of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, ChinaCollege of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, ChinaDepartment of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan, ChinaDepartment of Clinical Pharmacy, The 940th Hospital of Joint Logistic Support Force of Chinese of PLA, Gansu Plateau Pharmaceutical Technology Center, Lanzhou, ChinaCollege of Pharmacy, Lanzhou University, Lanzhou, ChinaCrocetin is an aglycone of crocin naturally occurring in saffron and produced in biological systems by hydrolysis of crocin as a bioactive metabolite. It is known to exist in several medicinal plants, the desiccative ripe fruit of the cape jasmine belonging to the Rubiaceae family, and stigmas of the saffron plant of the Iridaceae family. According to modern pharmacological investigations, crocetin possesses cardioprotective, hepatoprotective, neuroprotective, antidepressant, antiviral, anticancer, atherosclerotic, antidiabetic, and memory-enhancing properties. Although poor bioavailability hinders therapeutic applications, derivatization and formulation preparation technologies have broadened the application prospects for crocetin. To promote the research and development of crocetin, we summarized the distribution, preparation and production, total synthesis and derivatization technology, pharmacological activity, pharmacokinetics, drug safety, drug formulations, and preparation of crocetin.https://www.frontiersin.org/articles/10.3389/fphar.2021.745683/fullcrocetincrocetin derivativesdistributionpharmacological activitypharmacokineticstoxicity |
| spellingShingle | Zi-Liang Guo Zi-Liang Guo Mao-Xing Li Mao-Xing Li Mao-Xing Li Xiao-Lin Li Peng Wang Peng Wang Wei-Gang Wang Wei-Gang Wang Wei-Ze Du Wei-Ze Du Zhi-Qiang Yang Zhi-Qiang Yang Sheng-Fu Chen Sheng-Fu Chen Di Wu Di Wu Xiu-Yu Tian Xiu-Yu Tian Crocetin: A Systematic Review Frontiers in Pharmacology crocetin crocetin derivatives distribution pharmacological activity pharmacokinetics toxicity |
| title | Crocetin: A Systematic Review |
| title_full | Crocetin: A Systematic Review |
| title_fullStr | Crocetin: A Systematic Review |
| title_full_unstemmed | Crocetin: A Systematic Review |
| title_short | Crocetin: A Systematic Review |
| title_sort | crocetin a systematic review |
| topic | crocetin crocetin derivatives distribution pharmacological activity pharmacokinetics toxicity |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.745683/full |
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