Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation
Patients undergoing radiotherapy to treat pelvic-organ cancer are commonly advised to follow a restricted fiber diet. However, reducing dietary fiber may promote gastrointestinal inflammation, eventually leading to deteriorated intestinal health. The goal of this study was to evaluate the influence...
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MDPI AG
2020-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/8/2172 |
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| author | Piyush Patel Dilip Kumar Malipatlolla Sravani Devarakonda Cecilia Bull Ana Rascón Margareta Nyman Andrea Stringer Valentina Tremaroli Gunnar Steineck Fei Sjöberg |
| author_facet | Piyush Patel Dilip Kumar Malipatlolla Sravani Devarakonda Cecilia Bull Ana Rascón Margareta Nyman Andrea Stringer Valentina Tremaroli Gunnar Steineck Fei Sjöberg |
| author_sort | Piyush Patel |
| collection | DOAJ |
| description | Patients undergoing radiotherapy to treat pelvic-organ cancer are commonly advised to follow a restricted fiber diet. However, reducing dietary fiber may promote gastrointestinal inflammation, eventually leading to deteriorated intestinal health. The goal of this study was to evaluate the influence of dietary fiber on radiation-induced inflammation. C57BL/6J male mice were fed a High-oat bran diet (15% fiber) or a No-fiber diet (0% fiber) and were either irradiated (32 Gy delivered in four fractions) to the colorectal region or only sedated (controls). The dietary intervention started at 2 weeks before irradiation and lasted for 1, 6, and 18 weeks after irradiation, at which time points mice were sacrificed and their serum samples were assayed for 23 cytokines and chemokines. Our analyses show that irradiation increased the serum cytokine levels at all the time points analyzed. The No-fiber irradiated mice had significantly higher levels of pro-inflammatory cytokines than the High-oat irradiated mice at all time points. The results indicate that a fiber-rich oat bran diet reduces the intensity of radiation-induced inflammation, both at an early and late stage. Based on the results, it seems that the advice to follow a low-fiber diet during radiotherapy may increase the risk of decreased intestinal health in cancer survivors. |
| first_indexed | 2024-03-10T18:17:56Z |
| format | Article |
| id | doaj.art-74f90dbe75574319ae9b57e1b27cc4ea |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:17:56Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-74f90dbe75574319ae9b57e1b27cc4ea2023-11-20T07:34:53ZengMDPI AGNutrients2072-66432020-07-01128217210.3390/nu12082172Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic IrradiationPiyush Patel0Dilip Kumar Malipatlolla1Sravani Devarakonda2Cecilia Bull3Ana Rascón4Margareta Nyman5Andrea Stringer6Valentina Tremaroli7Gunnar Steineck8Fei Sjöberg9Division of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, SwedenDivision of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, SwedenDivision of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, SwedenDivision of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, SwedenDepartment of Food Technology, Engineering and Nutrition, Lund University, 22100 Lund, SwedenDepartment of Food Technology, Engineering and Nutrition, Lund University, 22100 Lund, SwedenSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide SA 5001, AustraliaThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, SwedenDivision of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, SwedenDivision of Clinical Cancer Epidemiology, Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, SwedenPatients undergoing radiotherapy to treat pelvic-organ cancer are commonly advised to follow a restricted fiber diet. However, reducing dietary fiber may promote gastrointestinal inflammation, eventually leading to deteriorated intestinal health. The goal of this study was to evaluate the influence of dietary fiber on radiation-induced inflammation. C57BL/6J male mice were fed a High-oat bran diet (15% fiber) or a No-fiber diet (0% fiber) and were either irradiated (32 Gy delivered in four fractions) to the colorectal region or only sedated (controls). The dietary intervention started at 2 weeks before irradiation and lasted for 1, 6, and 18 weeks after irradiation, at which time points mice were sacrificed and their serum samples were assayed for 23 cytokines and chemokines. Our analyses show that irradiation increased the serum cytokine levels at all the time points analyzed. The No-fiber irradiated mice had significantly higher levels of pro-inflammatory cytokines than the High-oat irradiated mice at all time points. The results indicate that a fiber-rich oat bran diet reduces the intensity of radiation-induced inflammation, both at an early and late stage. Based on the results, it seems that the advice to follow a low-fiber diet during radiotherapy may increase the risk of decreased intestinal health in cancer survivors.https://www.mdpi.com/2072-6643/12/8/2172pelvic radiotherapyradiation-induced inflammationserum cytokinesdietary fiberoat bran |
| spellingShingle | Piyush Patel Dilip Kumar Malipatlolla Sravani Devarakonda Cecilia Bull Ana Rascón Margareta Nyman Andrea Stringer Valentina Tremaroli Gunnar Steineck Fei Sjöberg Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation Nutrients pelvic radiotherapy radiation-induced inflammation serum cytokines dietary fiber oat bran |
| title | Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation |
| title_full | Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation |
| title_fullStr | Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation |
| title_full_unstemmed | Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation |
| title_short | Dietary Oat Bran Reduces Systemic Inflammation in Mice Subjected to Pelvic Irradiation |
| title_sort | dietary oat bran reduces systemic inflammation in mice subjected to pelvic irradiation |
| topic | pelvic radiotherapy radiation-induced inflammation serum cytokines dietary fiber oat bran |
| url | https://www.mdpi.com/2072-6643/12/8/2172 |
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