Pathomorphological and immunohistochemical findings of subacute lobullary calcifying panniculitis in two cats
This report aimed to reveal the characteristics of calcifying panniculitis in two cats. Two biopsies taken from the lumbosacral region of an 8-month old and a 1-year old, male, mixed breed cats were evaluated. Macroscopically, there were masses of different sizes varying from 1.5 to 2.5 cm in diamet...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2018-01-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2323 |
| _version_ | 1797800647416872960 |
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| author | Mehmet Eray ALCIGIR Tuncer KUTLU Gunay ALCIGIR |
| author_facet | Mehmet Eray ALCIGIR Tuncer KUTLU Gunay ALCIGIR |
| author_sort | Mehmet Eray ALCIGIR |
| collection | DOAJ |
| description | This report aimed to reveal the characteristics of calcifying panniculitis in two cats. Two biopsies taken from the lumbosacral region of an
8-month old and a 1-year old, male, mixed breed cats were evaluated. Macroscopically, there were masses of different sizes varying from 1.5 to
2.5 cm in diameter. The masses had a generally firmness and were grayish-white in colour. Histopathology revealed necrotic and degenerative
lipocytes in lobules of subcutaenous fat tissue. In some areas, there were lymphocyte, macrophage and neutrophil leukocytes infiltrations and
connective tissue proliferation. There were also large calcifying areas at the centre of degenerated-necrotic fat lobules. Alizarin Red S detected
the calcifying areas and Masson"s trichrome differentiated connective tissue proliferation. In ABC-P, CD3 slightly reacted with lymphocytes and
lymphoblasts. Vimentin moderately reacted with connective tissue proliferation at the periphery of the necrotic areas and the septum. A1AC
reacted in the cytoplasm of macrophages and peripheral necrotic areas. No reaction was determined with A1AT. In conclusion, such cases have
not been documented in veterinary pathology. It is believed that the two cats possibly had a renal deficiency problem or nephrotic syndrome
in the pathogenetic mechanism. It was also considered that A1AC (serine proteinase inhibitor) expressions could have a role in such cases
despite there being no A1AT (another serine proteinase inhibitor) expression. |
| first_indexed | 2024-03-13T04:37:25Z |
| format | Article |
| id | doaj.art-74f95130da4846298c49c61adcc39060 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:37:25Z |
| publishDate | 2018-01-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-74f95130da4846298c49c61adcc390602023-06-19T06:44:09ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512018-01-0124231131410.9775/kvfd.2017.187452323Pathomorphological and immunohistochemical findings of subacute lobullary calcifying panniculitis in two catsMehmet Eray ALCIGIR0Tuncer KUTLU1Gunay ALCIGIR2Ankara University, Faculty of Veterinary Medicine, Department of Pathology, TR-06110 Diskapi, Ankara - TURKEYMustafa Kemal Univ., Faculty of Veterinary Medicine, Department of Pathology, TR-31060 Alahan, Antakya/Hatay - TURKEYAnkara University, Faculty of Veterinary Medicine, Department of Pathology, TR-06110 Diskapi, Ankara - TURKEYThis report aimed to reveal the characteristics of calcifying panniculitis in two cats. Two biopsies taken from the lumbosacral region of an 8-month old and a 1-year old, male, mixed breed cats were evaluated. Macroscopically, there were masses of different sizes varying from 1.5 to 2.5 cm in diameter. The masses had a generally firmness and were grayish-white in colour. Histopathology revealed necrotic and degenerative lipocytes in lobules of subcutaenous fat tissue. In some areas, there were lymphocyte, macrophage and neutrophil leukocytes infiltrations and connective tissue proliferation. There were also large calcifying areas at the centre of degenerated-necrotic fat lobules. Alizarin Red S detected the calcifying areas and Masson"s trichrome differentiated connective tissue proliferation. In ABC-P, CD3 slightly reacted with lymphocytes and lymphoblasts. Vimentin moderately reacted with connective tissue proliferation at the periphery of the necrotic areas and the septum. A1AC reacted in the cytoplasm of macrophages and peripheral necrotic areas. No reaction was determined with A1AT. In conclusion, such cases have not been documented in veterinary pathology. It is believed that the two cats possibly had a renal deficiency problem or nephrotic syndrome in the pathogenetic mechanism. It was also considered that A1AC (serine proteinase inhibitor) expressions could have a role in such cases despite there being no A1AT (another serine proteinase inhibitor) expression.https://vetdergikafkas.org/pdf.php?id=2323calcifying panniculitiscatimmunohistochemistrypathomorphology |
| spellingShingle | Mehmet Eray ALCIGIR Tuncer KUTLU Gunay ALCIGIR Pathomorphological and immunohistochemical findings of subacute lobullary calcifying panniculitis in two cats Kafkas Universitesi Veteriner Fakültesi Dergisi calcifying panniculitis cat immunohistochemistry pathomorphology |
| title | Pathomorphological and immunohistochemical findings of subacute lobullary calcifying panniculitis in two cats |
| title_full | Pathomorphological and immunohistochemical findings of subacute lobullary calcifying panniculitis in two cats |
| title_fullStr | Pathomorphological and immunohistochemical findings of subacute lobullary calcifying panniculitis in two cats |
| title_full_unstemmed | Pathomorphological and immunohistochemical findings of subacute lobullary calcifying panniculitis in two cats |
| title_short | Pathomorphological and immunohistochemical findings of subacute lobullary calcifying panniculitis in two cats |
| title_sort | pathomorphological and immunohistochemical findings of subacute lobullary calcifying panniculitis in two cats |
| topic | calcifying panniculitis cat immunohistochemistry pathomorphology |
| url | https://vetdergikafkas.org/pdf.php?id=2323 |
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