A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer
Purpose: Cuproptosis, a form of copper-induced cell death, can be a promising therapeutic target for refractory cancers. Hence, we conducted this research to explore the association between cuproptosis and prognosis in cervical cancer (CC).Methods: For constructing a prognostic signature based on cu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.957744/full |
| _version_ | 1818515364817928192 |
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| author | Lei Lei Liao Tan Long Sui |
| author_facet | Lei Lei Liao Tan Long Sui |
| author_sort | Lei Lei |
| collection | DOAJ |
| description | Purpose: Cuproptosis, a form of copper-induced cell death, can be a promising therapeutic target for refractory cancers. Hence, we conducted this research to explore the association between cuproptosis and prognosis in cervical cancer (CC).Methods: For constructing a prognostic signature based on cuproptosis-related genes from TCGA database, the least absolute shrinkage and selection operator Cox regression was utilized. The GSE44001 cohort was utilized for validation.Results: A total of nine cuproptosis-related genes showed distinct expression in CC and normal samples in TCGA-GTEx cohort. Two risk groups were identified based on a seven-gene signature. A significant decrease in overall survival was observed in the high-risk group (p < 0.001). The risk score (HR = 2.77, 95% CI = 1.58–4.86) was an autocephalous predictor with a better predictive ability than the clinical stage. Functional analysis indicated that immune activities were suppressed more in the high-risk group than in the low-risk group. A total of 11 candidate compounds targeting the signature were identified.Conclusion: A total of seven cuproptosis-related gene signatures were constructed to predict prognosis and propose a new therapeutic target for patients with CC. |
| first_indexed | 2024-12-11T00:27:58Z |
| format | Article |
| id | doaj.art-74f9cf9c0f7a49c2a16b75b79f31aa40 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-11T00:27:58Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-74f9cf9c0f7a49c2a16b75b79f31aa402022-12-22T01:27:28ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.957744957744A novel cuproptosis-related gene signature for predicting prognosis in cervical cancerLei Lei0Liao Tan1Long Sui2Cervical and Vaginal Precancerous Lesion Diagnosis and Treatment, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, ChinaCervical and Vaginal Precancerous Lesion Diagnosis and Treatment, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaPurpose: Cuproptosis, a form of copper-induced cell death, can be a promising therapeutic target for refractory cancers. Hence, we conducted this research to explore the association between cuproptosis and prognosis in cervical cancer (CC).Methods: For constructing a prognostic signature based on cuproptosis-related genes from TCGA database, the least absolute shrinkage and selection operator Cox regression was utilized. The GSE44001 cohort was utilized for validation.Results: A total of nine cuproptosis-related genes showed distinct expression in CC and normal samples in TCGA-GTEx cohort. Two risk groups were identified based on a seven-gene signature. A significant decrease in overall survival was observed in the high-risk group (p < 0.001). The risk score (HR = 2.77, 95% CI = 1.58–4.86) was an autocephalous predictor with a better predictive ability than the clinical stage. Functional analysis indicated that immune activities were suppressed more in the high-risk group than in the low-risk group. A total of 11 candidate compounds targeting the signature were identified.Conclusion: A total of seven cuproptosis-related gene signatures were constructed to predict prognosis and propose a new therapeutic target for patients with CC.https://www.frontiersin.org/articles/10.3389/fgene.2022.957744/fullcervical cancercuproptosisgene signatureprognosistumor immune microenvironment |
| spellingShingle | Lei Lei Liao Tan Long Sui A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer Frontiers in Genetics cervical cancer cuproptosis gene signature prognosis tumor immune microenvironment |
| title | A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer |
| title_full | A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer |
| title_fullStr | A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer |
| title_full_unstemmed | A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer |
| title_short | A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer |
| title_sort | novel cuproptosis related gene signature for predicting prognosis in cervical cancer |
| topic | cervical cancer cuproptosis gene signature prognosis tumor immune microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.957744/full |
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