DNA Nanoparticles: Detection of Long-Term Transgene Activity in Brain using Bioluminescence Imaging

DNA Nanoparticles: Detection of Long-Term Transgene Activity in Brain using Bioluminescence Imaging

In this study, we used bioluminescence imaging (BLI) to track long-term transgene activity following the transfection of brain cells using a nonviral gene therapy technique. Formulations of deoxyribonucleic acid (DNA) combined with 30-mer lysine polymers (substituted with 10 kDa polyethylene glycol)...

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Bibliographic Details
Main Authors: David M. Yurek, Anita M. Fletcher, Matthew McShane, Tomasz H. Kowalczyk, Linas Padegimas, Marcy R. Weatherspoon, Michael D. Kaytor, Mark J. Cooper, Assem G. Ziady
Format: Article
Language:English
Published: SAGE Publications 2011-09-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2010.00053

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