Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers
Background: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs). We aimed to investigate the association of UCa with serum sclerostin, bo...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/15/5027 |
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| author | Fernanda Guedes Rodrigues Milene Subtil Ormanji Igor Gouveia Pietrobom Ana Cristina Carvalho de Matos Martin H. De Borst Ita Pfeferman Heilberg |
| author_facet | Fernanda Guedes Rodrigues Milene Subtil Ormanji Igor Gouveia Pietrobom Ana Cristina Carvalho de Matos Martin H. De Borst Ita Pfeferman Heilberg |
| author_sort | Fernanda Guedes Rodrigues |
| collection | DOAJ |
| description | Background: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs). We aimed to investigate the association of UCa with serum sclerostin, bone mineral density (BMD), and body composition among SFs. Methods: Clinical and laboratorial data were retrieved from medical records. Determinants of UCa were studied using linear regression. Results: A total of 107 SFs (35.8 ± 9.3 years, 54% male) with eGFR 99.8 ± 14.5 mL/min/1.73 were studied. Subjects were split by sex and grouped into tertiles of UCa levels. Men in the highest UCa tertile had higher body mass index (BMI) and serum sclerostin, lower lean mass, and a trend towards higher fat mass. Women in the highest tertile had higher BMI and a trend towards higher serum sclerostin. Hypertension and metabolic syndrome, but not lower BMD, were more prevalent in the highest UCa tertile for both sexes. Sclerostin was positively correlated with fat mass and inversely correlated with lean mass among men, but not among women. BMD corrected for BMI at lumbar spine was inversely associated with UCa in a univariate analysis, but only serum sclerostin, hypertension, and NaCl intake were independent determinants of UCa in the multivariate model. Conclusion: The present findings disclose that in addition to hypertension and salt intake, serum sclerostin is associated with urinary calcium in stone formers, suggesting that in addition to the hormones traditionally thought to alter calcium reabsorption in the kidney, sclerostin may play a significant additional role, warranting further investigation. |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:24:28Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-74fd4036362143729b9d15ed3df2e8382023-11-18T23:08:25ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011215502710.3390/jcm12155027Urinary Calcium Is Associated with Serum Sclerostin among Stone FormersFernanda Guedes Rodrigues0Milene Subtil Ormanji1Igor Gouveia Pietrobom2Ana Cristina Carvalho de Matos3Martin H. De Borst4Ita Pfeferman Heilberg5Nutrition Post Graduation Program, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDivision of Nephrology, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDivision of Nephrology, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDivision of Nephrology, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDepartment of Nephrology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsNutrition Post Graduation Program, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilBackground: Sclerostin plays an important role in bone metabolism and adipose tissue. Animal studies suggest that sclerostin influences urinary calcium (UCa), but this relationship has not been evaluated in stone formers (SFs). We aimed to investigate the association of UCa with serum sclerostin, bone mineral density (BMD), and body composition among SFs. Methods: Clinical and laboratorial data were retrieved from medical records. Determinants of UCa were studied using linear regression. Results: A total of 107 SFs (35.8 ± 9.3 years, 54% male) with eGFR 99.8 ± 14.5 mL/min/1.73 were studied. Subjects were split by sex and grouped into tertiles of UCa levels. Men in the highest UCa tertile had higher body mass index (BMI) and serum sclerostin, lower lean mass, and a trend towards higher fat mass. Women in the highest tertile had higher BMI and a trend towards higher serum sclerostin. Hypertension and metabolic syndrome, but not lower BMD, were more prevalent in the highest UCa tertile for both sexes. Sclerostin was positively correlated with fat mass and inversely correlated with lean mass among men, but not among women. BMD corrected for BMI at lumbar spine was inversely associated with UCa in a univariate analysis, but only serum sclerostin, hypertension, and NaCl intake were independent determinants of UCa in the multivariate model. Conclusion: The present findings disclose that in addition to hypertension and salt intake, serum sclerostin is associated with urinary calcium in stone formers, suggesting that in addition to the hormones traditionally thought to alter calcium reabsorption in the kidney, sclerostin may play a significant additional role, warranting further investigation.https://www.mdpi.com/2077-0383/12/15/5027kidney stonesurinary calciumserum sclerostinbone mineral density |
| spellingShingle | Fernanda Guedes Rodrigues Milene Subtil Ormanji Igor Gouveia Pietrobom Ana Cristina Carvalho de Matos Martin H. De Borst Ita Pfeferman Heilberg Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers Journal of Clinical Medicine kidney stones urinary calcium serum sclerostin bone mineral density |
| title | Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers |
| title_full | Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers |
| title_fullStr | Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers |
| title_full_unstemmed | Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers |
| title_short | Urinary Calcium Is Associated with Serum Sclerostin among Stone Formers |
| title_sort | urinary calcium is associated with serum sclerostin among stone formers |
| topic | kidney stones urinary calcium serum sclerostin bone mineral density |
| url | https://www.mdpi.com/2077-0383/12/15/5027 |
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