Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study
This randomized double-blinded, placebo-controlled clinical trial evaluated the progression of intima-media thickness of common carotid artery (cIMT) and the effect of phytoestrogen therapy on atherosclerosis development in early and late postmenopausal women. The 2-year cIMT progression was evaluat...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/9/3/48 |
| _version_ | 1797711860547452928 |
|---|---|
| author | Tatiana V. Kirichenko Veronika A. Myasoedova Alessio L. Ravani Igor A. Sobenin Varvara A. Orekhova Elena B. Romanenko Paolo Poggio Wei-Kai Wu Alexander N. Orekhov |
| author_facet | Tatiana V. Kirichenko Veronika A. Myasoedova Alessio L. Ravani Igor A. Sobenin Varvara A. Orekhova Elena B. Romanenko Paolo Poggio Wei-Kai Wu Alexander N. Orekhov |
| author_sort | Tatiana V. Kirichenko |
| collection | DOAJ |
| description | This randomized double-blinded, placebo-controlled clinical trial evaluated the progression of intima-media thickness of common carotid artery (cIMT) and the effect of phytoestrogen therapy on atherosclerosis development in early and late postmenopausal women. The 2-year cIMT progression was evaluated in 315 early postmenopausal women aged 40−55 years and in 231 late postmenopausal women aged 60−69 years free of cardiovascular disease. B-mode ultrasound was done at baseline and after 12 and 24 months of follow-up. The study revealed no significant changes in the rate of cIMT progression in 315 early postmenopausal women. By contrast, a statistically significant difference in the rate of atherosclerosis development was observed in late postmenopausal women treated with phytoestrogens compared to placebo (<i>p =</i> 0.008). The rate of cIMT progression in the placebo group was 0.019 mm/year led to a significant increase of cIMT during the observation period (<i>p =</i> 0.012), while the rate of cIMT progression in phytoestrogen late postmenopausal recipients was 0.011 mm/year, and total change did not reach statistical significance during the follow-up period (<i>p =</i> 0.101). These results suggest that late postmenopausal women can be a suitable cohort for trials assessing the anti-atherosclerosis effects of phytoestrogen preparations. In particular, the beneficial effect of phytoestrogens on cIMT progression was demonstrated in late postmenopausal women. |
| first_indexed | 2024-03-12T07:12:57Z |
| format | Article |
| id | doaj.art-74ff9da2a496488084a85847674adb5e |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T07:12:57Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-74ff9da2a496488084a85847674adb5e2023-09-02T22:59:31ZengMDPI AGBiology2079-77372020-03-01934810.3390/biology9030048biology9030048Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement StudyTatiana V. Kirichenko0Veronika A. Myasoedova1Alessio L. Ravani2Igor A. Sobenin3Varvara A. Orekhova4Elena B. Romanenko5Paolo Poggio6Wei-Kai Wu7Alexander N. Orekhov8Research Institute of Human Morphology, 3 Tsyurupy Str., 117418 Moscow, RussiaInstitute of General Pathology and Pathophysiology, 8 Baltiyskaya Str., 125315 Moscow, RussiaCentro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, ItalyResearch Institute of Human Morphology, 3 Tsyurupy Str., 117418 Moscow, RussiaInstitute of General Pathology and Pathophysiology, 8 Baltiyskaya Str., 125315 Moscow, RussiaDepartment of Molecular Basis of Ontogenesis, Belozersky Institute of Physical and Chemical Biology, Moscow State University, 119234 Moscow, RussiaCentro Cardiologico Monzino IRCCS, Via Carlo Parea 4, 20138 Milan, ItalyDepartment of Internal Medicine, National Taiwan University Hospital, Bei-Hu Branch, Taipei 108, TaiwanResearch Institute of Human Morphology, 3 Tsyurupy Str., 117418 Moscow, RussiaThis randomized double-blinded, placebo-controlled clinical trial evaluated the progression of intima-media thickness of common carotid artery (cIMT) and the effect of phytoestrogen therapy on atherosclerosis development in early and late postmenopausal women. The 2-year cIMT progression was evaluated in 315 early postmenopausal women aged 40−55 years and in 231 late postmenopausal women aged 60−69 years free of cardiovascular disease. B-mode ultrasound was done at baseline and after 12 and 24 months of follow-up. The study revealed no significant changes in the rate of cIMT progression in 315 early postmenopausal women. By contrast, a statistically significant difference in the rate of atherosclerosis development was observed in late postmenopausal women treated with phytoestrogens compared to placebo (<i>p =</i> 0.008). The rate of cIMT progression in the placebo group was 0.019 mm/year led to a significant increase of cIMT during the observation period (<i>p =</i> 0.012), while the rate of cIMT progression in phytoestrogen late postmenopausal recipients was 0.011 mm/year, and total change did not reach statistical significance during the follow-up period (<i>p =</i> 0.101). These results suggest that late postmenopausal women can be a suitable cohort for trials assessing the anti-atherosclerosis effects of phytoestrogen preparations. In particular, the beneficial effect of phytoestrogens on cIMT progression was demonstrated in late postmenopausal women.https://www.mdpi.com/2079-7737/9/3/48womenpostmenopausecimt progressionatherosclerosisphytoestrogens |
| spellingShingle | Tatiana V. Kirichenko Veronika A. Myasoedova Alessio L. Ravani Igor A. Sobenin Varvara A. Orekhova Elena B. Romanenko Paolo Poggio Wei-Kai Wu Alexander N. Orekhov Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study Biology women postmenopause cimt progression atherosclerosis phytoestrogens |
| title | Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study |
| title_full | Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study |
| title_fullStr | Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study |
| title_full_unstemmed | Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study |
| title_short | Carotid Atherosclerosis Progression in Postmenopausal Women Receiving a Mixed Phytoestrogen Regimen: Plausible Parallels with Kronos Early Estrogen Replacement Study |
| title_sort | carotid atherosclerosis progression in postmenopausal women receiving a mixed phytoestrogen regimen plausible parallels with kronos early estrogen replacement study |
| topic | women postmenopause cimt progression atherosclerosis phytoestrogens |
| url | https://www.mdpi.com/2079-7737/9/3/48 |
| work_keys_str_mv | AT tatianavkirichenko carotidatherosclerosisprogressioninpostmenopausalwomenreceivingamixedphytoestrogenregimenplausibleparallelswithkronosearlyestrogenreplacementstudy AT veronikaamyasoedova carotidatherosclerosisprogressioninpostmenopausalwomenreceivingamixedphytoestrogenregimenplausibleparallelswithkronosearlyestrogenreplacementstudy AT alessiolravani carotidatherosclerosisprogressioninpostmenopausalwomenreceivingamixedphytoestrogenregimenplausibleparallelswithkronosearlyestrogenreplacementstudy AT igorasobenin carotidatherosclerosisprogressioninpostmenopausalwomenreceivingamixedphytoestrogenregimenplausibleparallelswithkronosearlyestrogenreplacementstudy AT varvaraaorekhova carotidatherosclerosisprogressioninpostmenopausalwomenreceivingamixedphytoestrogenregimenplausibleparallelswithkronosearlyestrogenreplacementstudy AT elenabromanenko carotidatherosclerosisprogressioninpostmenopausalwomenreceivingamixedphytoestrogenregimenplausibleparallelswithkronosearlyestrogenreplacementstudy AT paolopoggio carotidatherosclerosisprogressioninpostmenopausalwomenreceivingamixedphytoestrogenregimenplausibleparallelswithkronosearlyestrogenreplacementstudy AT weikaiwu carotidatherosclerosisprogressioninpostmenopausalwomenreceivingamixedphytoestrogenregimenplausibleparallelswithkronosearlyestrogenreplacementstudy AT alexandernorekhov carotidatherosclerosisprogressioninpostmenopausalwomenreceivingamixedphytoestrogenregimenplausibleparallelswithkronosearlyestrogenreplacementstudy |