Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservation
Purpose: We compared semen quality and sperm DNA fragmentation in cancer patients who underwent sperm banking and controls who underwent sperm cryopreservation for assisted reproductive technology (ART). Materials and Methods: A total of 132 men, 65 cancer patients and 67 controls, were prospective...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Urological Association
2023-09-01
|
| Series: | Investigative and Clinical Urology |
| Subjects: | |
| Online Access: | https://www.icurology.org/pdf/10.4111/icu.20220402 |
| _version_ | 1797690997548777472 |
|---|---|
| author | Seung-Hun Song Tae Ho Lee Young Sun Her Mihee Oh Dong Hyuk Shin Yohan Heo Dae Keun Kim Dong Suk Kim |
| author_facet | Seung-Hun Song Tae Ho Lee Young Sun Her Mihee Oh Dong Hyuk Shin Yohan Heo Dae Keun Kim Dong Suk Kim |
| author_sort | Seung-Hun Song |
| collection | DOAJ |
| description | Purpose: We compared semen quality and sperm DNA fragmentation in cancer patients who underwent sperm banking and controls who underwent sperm cryopreservation for assisted reproductive technology (ART).
Materials and Methods: A total of 132 men, 65 cancer patients and 67 controls, were prospectively enrolled and performed sperm cryopreservation for fertility preservation from May 2019 to February 2021. Sperm quality was determined by measuring semen volume, sperm concentration, sperm motility, and sperm DNA fragmentation index (DFI). Sperm quality and sperm DFI were compared in cancer patients and controls.
Results: The major cancers of the 65 cancer patients were leukemia (26.2%), testicular cancer (23.1%), and lymphoma (20.0%). Sperm concentration, sperm total motility, and sperm progressive motility were significantly lower in cancer patients than in controls. Sperm DFI was significantly higher in cancer patients than in controls (24.32%±15.69% vs. 19.11%±11.63%; p=0.033). After excluding 8 cancer patients who received chemotherapy before sperm banking, sperm concentration, sperm total motility, and sperm progressive motility were significantly lower in cancer patients than in controls, but there was no significant difference in sperm DFI for cancer patients and controls (23.14%±12.79% vs. 19.11%±11.63%; p=0.069).
Conclusions: Sperm quality was lower in cancer patients than in controls. There was no difference in the sperm DFI of cancer patients prior to chemotherapy and men presenting for sperm cryopreservation for ART. We recommend that all men who are planning cancer therapy should be offered sperm banking prior to gonadotoxic chemotherapy as a standard of fertility preservation. |
| first_indexed | 2024-03-12T02:07:14Z |
| format | Article |
| id | doaj.art-750214e76c054fbea783df35107aa12b |
| institution | Directory Open Access Journal |
| issn | 2466-0493 2466-054X |
| language | English |
| last_indexed | 2024-03-12T02:07:14Z |
| publishDate | 2023-09-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj.art-750214e76c054fbea783df35107aa12b2023-09-07T02:48:02ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2023-09-0164548949410.4111/icu.20220402Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservationSeung-Hun Song 0https://orcid.org/0000-0003-4649-9129Tae Ho Lee1https://orcid.org/0000-0002-6797-1042Young Sun Her2https://orcid.org/0000-0003-3678-2801Mihee Oh3https://orcid.org/0000-0002-2880-5738Dong Hyuk Shin4https://orcid.org/0000-0002-9789-237XYohan Heo5https://orcid.org/0000-0003-2341-6319Dae Keun Kim6https://orcid.org/0000-0003-3237-6304Dong Suk Kim 7https://orcid.org/0000-0001-7350-0303Department of Urology, CHA Fertility Center Gangnam, CHA Gangnam Medical Center, CHA University, Seoul, Korea.Department of Urology, CHA Fertility Center Gangnam, CHA Gangnam Medical Center, CHA University, Seoul, Korea.Andrology Lab, CHA Fertility Center Gangnam, CHA Gangnam Medical Center, CHA University, Seoul, Korea.Andrology Lab, CHA Fertility Center Gangnam, CHA Gangnam Medical Center, CHA University, Seoul, Korea.Andrology Lab, CHA Fertility Center Gangnam, CHA Gangnam Medical Center, CHA University, Seoul, Korea.Department of Urology, CHA Fertility Center Gangnam, CHA Gangnam Medical Center, CHA University, Seoul, Korea.Department of Urology, CHA Fertility Center, Seoul Station, CHA University, Seoul, Korea.Department of Urology, CHA Fertility Center Gangnam, CHA Gangnam Medical Center, CHA University, Seoul, Korea.Purpose: We compared semen quality and sperm DNA fragmentation in cancer patients who underwent sperm banking and controls who underwent sperm cryopreservation for assisted reproductive technology (ART). Materials and Methods: A total of 132 men, 65 cancer patients and 67 controls, were prospectively enrolled and performed sperm cryopreservation for fertility preservation from May 2019 to February 2021. Sperm quality was determined by measuring semen volume, sperm concentration, sperm motility, and sperm DNA fragmentation index (DFI). Sperm quality and sperm DFI were compared in cancer patients and controls. Results: The major cancers of the 65 cancer patients were leukemia (26.2%), testicular cancer (23.1%), and lymphoma (20.0%). Sperm concentration, sperm total motility, and sperm progressive motility were significantly lower in cancer patients than in controls. Sperm DFI was significantly higher in cancer patients than in controls (24.32%±15.69% vs. 19.11%±11.63%; p=0.033). After excluding 8 cancer patients who received chemotherapy before sperm banking, sperm concentration, sperm total motility, and sperm progressive motility were significantly lower in cancer patients than in controls, but there was no significant difference in sperm DFI for cancer patients and controls (23.14%±12.79% vs. 19.11%±11.63%; p=0.069). Conclusions: Sperm quality was lower in cancer patients than in controls. There was no difference in the sperm DFI of cancer patients prior to chemotherapy and men presenting for sperm cryopreservation for ART. We recommend that all men who are planning cancer therapy should be offered sperm banking prior to gonadotoxic chemotherapy as a standard of fertility preservation.https://www.icurology.org/pdf/10.4111/icu.20220402dna fragmentationneoplasmssemen preservation |
| spellingShingle | Seung-Hun Song Tae Ho Lee Young Sun Her Mihee Oh Dong Hyuk Shin Yohan Heo Dae Keun Kim Dong Suk Kim Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservation Investigative and Clinical Urology dna fragmentation neoplasms semen preservation |
| title | Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservation |
| title_full | Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservation |
| title_fullStr | Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservation |
| title_full_unstemmed | Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservation |
| title_short | Semen quality and sperm DNA fragmentation in cancer patients undergoing sperm cryopreservation |
| title_sort | semen quality and sperm dna fragmentation in cancer patients undergoing sperm cryopreservation |
| topic | dna fragmentation neoplasms semen preservation |
| url | https://www.icurology.org/pdf/10.4111/icu.20220402 |
| work_keys_str_mv | AT seunghunsong semenqualityandspermdnafragmentationincancerpatientsundergoingspermcryopreservation AT taeholee semenqualityandspermdnafragmentationincancerpatientsundergoingspermcryopreservation AT youngsunher semenqualityandspermdnafragmentationincancerpatientsundergoingspermcryopreservation AT miheeoh semenqualityandspermdnafragmentationincancerpatientsundergoingspermcryopreservation AT donghyukshin semenqualityandspermdnafragmentationincancerpatientsundergoingspermcryopreservation AT yohanheo semenqualityandspermdnafragmentationincancerpatientsundergoingspermcryopreservation AT daekeunkim semenqualityandspermdnafragmentationincancerpatientsundergoingspermcryopreservation AT dongsukkim semenqualityandspermdnafragmentationincancerpatientsundergoingspermcryopreservation |