Impact of ROS-Induced Damage of TCA Cycle Enzymes on Metabolism and Virulence of Salmonella enterica serovar Typhimurium

Impact of ROS-Induced Damage of TCA Cycle Enzymes on Metabolism and Virulence of Salmonella enterica serovar Typhimurium

Salmonella enterica serovar Typhimurium (STM) is exposed to reactive oxygen species (ROS) originating from aerobic respiration, antibiotic treatment, and the oxidative burst occurring inside the Salmonella-containing vacuole (SCV) within host cells. ROS damage cellular compounds, thereby impairing b...

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Bibliographic Details
Main Authors: Janina Noster, Marcus Persicke, Tzu-Chiao Chao, Lena Krone, Bianca Heppner, Michael Hensel, Nicole Hansmeier
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Microbiology
Subjects:
metabolomics
oxidative stress
iron–sulfur cluster damage
aconitase
superoxide dismutase
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00762/full

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