Inducible T-Cell Co-Stimulator Impacts Chronic Graft-Versus-Host Disease by Regulating Both Pathogenic and Regulatory T Cells

Inducible T-Cell Co-Stimulator Impacts Chronic Graft-Versus-Host Disease by Regulating Both Pathogenic and Regulatory T Cells

The incidence of chronic graft-versus-host disease (cGVHD) is on the rise and still the major cause of morbidity and mortality among patients after allogeneic hematopoietic stem cell transplantation (HCT). Both donor T and B cells contribute to the pathogenesis of cGVHD. Inducible T-cell co-stimulat...

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Bibliographic Details
Main Authors: Mengmeng Zhang, Yongxia Wu, David Bastian, Supinya Iamsawat, Jinsam Chang, Anusara Daenthanasanmak, Hung D. Nguyen, Steven Schutt, Min Dai, Fangping Chen, Woong-Kyung Suh, Xue-Zhong Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
inducible T-cell co-stimulator
chronic graft-versus-host disease
regulatory T cells
T follicular helper
follicular regulatory T
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01461/full

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