Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model
This study investigated the biological activities and phytochemical screening of Boswellia dalzielii root ethanol extract. Standard procures were used to evaluate the phytochemicals and antioxidant capacity, antipyretic activity in baker’s yeast-induced pyrexia in mice, analgesic property (hotplate...
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| Format: | Article |
| Language: | English |
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State Islamic University Sunan Kalijaga
2023-01-01
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| Series: | Biology, Medicine & Natural Product Chemistry |
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| Online Access: | https://sciencebiology.org/index.php/BIOMEDICH/article/view/270 |
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| author | MacDonald Idu Anthonia Omoregbee Benjamin Ogunma Gabriel |
| author_facet | MacDonald Idu Anthonia Omoregbee Benjamin Ogunma Gabriel |
| author_sort | MacDonald Idu |
| collection | DOAJ |
| description | This study investigated the biological activities and phytochemical screening of Boswellia dalzielii root ethanol extract. Standard procures were used to evaluate the phytochemicals and antioxidant capacity, antipyretic activity in baker’s yeast-induced pyrexia in mice, analgesic property (hotplate and acetic acid-induced in mice), acute anti–inflammation (carrageenan-induce in rats) and chronic arthritis (formalin–induced in rats) on Boswellia dalzielii root ethanol extract. The phytochemical results revealed the presence of phenol, ascorbic acid, flavonoids, alkaloids, cardiac glycoside, tannin, saponin. The extract had a significant reduction in the body temperature in graded doses and 100 mg/kg paracetamol at 60 minutes when compared with the control, but 400 mg/kg was more effective (p<0.01). Morphine and plant extract showed a slight significant analgesic property at 0 and 30 minute compared to the control. The extract at 100 mg/kg elicited a significant increase at 60 and 90 minutes compared with the control, and it is comparable to 5 mg/kg morphine. The plant extract (100, 200, and 400 mg/kg) and aspirin (100mg/kg) shows significant analgesic properties compared to control (p<0.01) but 200 mg/kg of extract revealed highest percentage inhibition. The extract produced no significant reduction on carrageenan induced inflammatory at all dose level compared to control (p>0.05). The plant extract (100, 200, 400 mg/kg) and Indomethacin (1 mg/kg) reduced paw volume across the doses from day 4 compared to the control (p<0.01). The Boswellia dalzielii root extract is a promising anti–inflammatory agent, it also possesses antipyretics, and analgesics effect validating the folklore claim. |
| first_indexed | 2024-03-12T15:06:24Z |
| format | Article |
| id | doaj.art-75030c1da3aa4946812425ca1dc79bb8 |
| institution | Directory Open Access Journal |
| issn | 2089-6514 2540-9328 |
| language | English |
| last_indexed | 2024-03-12T15:06:24Z |
| publishDate | 2023-01-01 |
| publisher | State Islamic University Sunan Kalijaga |
| record_format | Article |
| series | Biology, Medicine & Natural Product Chemistry |
| spelling | doaj.art-75030c1da3aa4946812425ca1dc79bb82023-08-12T13:10:11ZengState Islamic University Sunan KalijagaBiology, Medicine & Natural Product Chemistry2089-65142540-93282023-01-0112114315010.14421/biomedich.2023.121.143-150163Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal ModelMacDonald Idu0Anthonia Omoregbee1Benjamin Ogunma Gabriel2University of BeninUniversity of BeninUniversity of BeninThis study investigated the biological activities and phytochemical screening of Boswellia dalzielii root ethanol extract. Standard procures were used to evaluate the phytochemicals and antioxidant capacity, antipyretic activity in baker’s yeast-induced pyrexia in mice, analgesic property (hotplate and acetic acid-induced in mice), acute anti–inflammation (carrageenan-induce in rats) and chronic arthritis (formalin–induced in rats) on Boswellia dalzielii root ethanol extract. The phytochemical results revealed the presence of phenol, ascorbic acid, flavonoids, alkaloids, cardiac glycoside, tannin, saponin. The extract had a significant reduction in the body temperature in graded doses and 100 mg/kg paracetamol at 60 minutes when compared with the control, but 400 mg/kg was more effective (p<0.01). Morphine and plant extract showed a slight significant analgesic property at 0 and 30 minute compared to the control. The extract at 100 mg/kg elicited a significant increase at 60 and 90 minutes compared with the control, and it is comparable to 5 mg/kg morphine. The plant extract (100, 200, and 400 mg/kg) and aspirin (100mg/kg) shows significant analgesic properties compared to control (p<0.01) but 200 mg/kg of extract revealed highest percentage inhibition. The extract produced no significant reduction on carrageenan induced inflammatory at all dose level compared to control (p>0.05). The plant extract (100, 200, 400 mg/kg) and Indomethacin (1 mg/kg) reduced paw volume across the doses from day 4 compared to the control (p<0.01). The Boswellia dalzielii root extract is a promising anti–inflammatory agent, it also possesses antipyretics, and analgesics effect validating the folklore claim.https://sciencebiology.org/index.php/BIOMEDICH/article/view/270phytochemicals, ethanolboswellia dalzieliipyrexiaanti-inflammatorymice |
| spellingShingle | MacDonald Idu Anthonia Omoregbee Benjamin Ogunma Gabriel Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model Biology, Medicine & Natural Product Chemistry phytochemicals, ethanol boswellia dalzielii pyrexia anti-inflammatory mice |
| title | Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model |
| title_full | Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model |
| title_fullStr | Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model |
| title_full_unstemmed | Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model |
| title_short | Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model |
| title_sort | phytochemical antioxidant screening antinociceptive and anti inflammatory activities of boswellia dalzielii hutch burseraceae root ethanol extract using animal model |
| topic | phytochemicals, ethanol boswellia dalzielii pyrexia anti-inflammatory mice |
| url | https://sciencebiology.org/index.php/BIOMEDICH/article/view/270 |
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